Trial · NCT01028846
Central Mechanisms That Regulate Glucose Metabolism in Humans
NCT01028846, Phase 4, Terminated, Meredith Hawkins; results first posted 2025-03-14
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Central Mechanisms That Regulate Glucose Metabolism in Humans. Trials, record NCT01028846. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT01028846
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Central Mechanisms That Regulate Glucose Metabolism in Humans
- NCT number
- NCT01028846
- Status
- Terminated
- Phases
- Phase 4
- Enrollment
- 10 participants, actual
- Lead sponsor
- Meredith Hawkins
- Conditions
- Type 2 Diabetes, Glucose Metabolism Disorders, Glucose, High Blood
- Interventions
- Diazoxide, Placebo
- First posted
- 2009-12-09
- Last updated
- 2025-05-16
- Results first posted
- 2025-03-14
Source ClinicalTrials.gov
Registered outcomes1
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Rate of Endogenous Glucose Production (EGP) | Final 60 minutes (t=180-240 minutes) of the pancreatic clamp, 6-7 hours after dosing | Rate of EGP (a measure of the body's production of sugar) was measured using analysis of blood samples taken throughout the pancreatic clamp procedure under various treatment conditions (e.g., diazoxide or placebo) by monitoring changes in the level of a non-radioactive, naturally occurring form of glucose (sugar). Rates were summarized by treatment (Diazoxide or Placebo) in mg/kg/min sing basic descriptive statistics. |
Source ClinicalTrials.gov
Outcomes1
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Rate of Endogenous Glucose Production (EGP) | Final 60 minutes (t=180-240 minutes) of the pancreatic clamp, 6-7 hours after dosing | mg/kg/min | MEAN |
Source ClinicalTrials.gov
Results by group2
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Rate of Endogenous Glucose Production (EGP) | Diazoxide | 1.15 | Standard Error 0.13 | mg/kg/min | |
| Rate of Endogenous Glucose Production (EGP) | Placebo | 1.63 | Standard Error 0.17 | mg/kg/min |
Source ClinicalTrials.gov
Participant flow18
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| 1st Intervention | STARTED | Diazoxide Followed by Placebo | 5 | |
| 1st Intervention | STARTED | Placebo Followed by Diazoxide | 5 | |
| 1st Intervention | COMPLETED | Diazoxide Followed by Placebo | 5 | |
| 1st Intervention | COMPLETED | Placebo Followed by Diazoxide | 5 | |
| 1st Intervention | NOT COMPLETED | Diazoxide Followed by Placebo | 0 | |
| 1st Intervention | NOT COMPLETED | Placebo Followed by Diazoxide | 0 | |
| Washout (~1 Month) | STARTED | Diazoxide Followed by Placebo | 5 | |
| Washout (~1 Month) | STARTED | Placebo Followed by Diazoxide | 5 | |
| Washout (~1 Month) | COMPLETED | Diazoxide Followed by Placebo | 5 | |
| Washout (~1 Month) | COMPLETED | Placebo Followed by Diazoxide | 5 |
1 to 10 of 18Source ClinicalTrials.gov
See all 18 participant flowAdverse events2
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| other | Mild Hypoglycemia (Asymptomatic) | Metabolism and nutrition disorders | Diazoxide | 1 | 10 | |
| other | Mild Hypoglycemia (Asymptomatic) | Metabolism and nutrition disorders | Placebo | 0 | 10 |
Source ClinicalTrials.gov
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Diazoxide | 0 | 10 |
| Total, all-cause mortality | Placebo | 0 | 10 |
| Total, other adverse events | Diazoxide | 1 | 10 |
| Total, other adverse events | Placebo | 0 | 10 |
| Total, serious adverse events | Diazoxide | 0 | 10 |
| Total, serious adverse events | Placebo | 0 | 10 |
Source ClinicalTrials.gov
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 22056385 | RESULT |
Source PubMed
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| R01DK069861 | Restoring Central Regulation of Glucose Production in Type 2 Diabetes | HAWKINS, MEREDITH A; ROUTH, VANESSA H | ALBERT EINSTEIN COLLEGE OF MEDICINE | NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES | 2006 to 2025 |
Source NIH RePORTER
Trial comparisons2
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Diazoxide vs Placebo: deaths from any cause | Trial comparisons |
| Diazoxide vs Placebo: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT01028846
GET https://conductscience.org/api/trials/v1/NCT01028846/registered