Trial · NCT01032018

Comparison of Depression Interventions After Acute Coronary Syndrome

NCT01032018, Phase 1, Phase 2, Completed, Columbia University; results first posted 2014-08-12

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Comparison of Depression Interventions After Acute Coronary Syndrome. Trials, record NCT01032018. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT01032018

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Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Comparison of Depression Interventions After Acute Coronary Syndrome
NCT number: NCT01032018
Status: Completed
Phases: Phase 1, Phase 2
Enrollment: 150 participants, actual
Lead sponsor: Columbia University
Conditions: Acute Coronary Syndrome, Depression
Interventions: Problem Solving Therapy, Sertraline, citalopram, or bupropion, Standard care
First posted: 2009-12-15
Last updated: 2017-09-13
Results first posted: 2014-08-12

Source ClinicalTrials.gov

Registered outcomes2

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Depressive Symptom Reduction	Change from depression at baseline to depression at 6-months	Symptoms of depression were assessed using the Beck Depression Inventory (BDI). This 21-question, multiple choice self-report instrument includes items pertaining to symptoms of depression, including hopelessness and irritability, physical symptoms such as fatigue, and thoughts such as guilt. Each item has at a set of four possible responses, ranging in intensity for least intense to most intense. The total score is calculated by adding the responses to each item. Higher scores indicate more severe depressive symptoms. The total score on the scale ranges from 0 to 63. Total scores on the scale of less 10 indicate minimal depression; total scores between 10 and 15 indicate mild depression; and total scores greater than 16 indicate a probable clinical diagnosis of depression.
Primary	Cost for Healthcare Utilization (Psychiatric Medications, Hospitalizations, Cardiac Procedures, Outpatient Services)	6 months after randomization

Source ClinicalTrials.gov

Outcomes2

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Population	Units	Measured as
PRIMARY	Depressive Symptom Reduction	Change from depression at baseline to depression at 6-months		Scores on a scale	MEAN
PRIMARY	Cost for Healthcare Utilization (Psychiatric Medications, Hospitalizations, Cardiac Procedures, Outpatient Services)	6 months after randomization		dollars	MEAN

Source ClinicalTrials.gov

Results by group4

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Spread	Units
Depressive Symptom Reduction	Referred Care	-6.6	Standard Deviation 1.0	Scores on a scale
Depressive Symptom Reduction	Stepped Care	-10.1	Standard Deviation 0.9	Scores on a scale
Cost for Healthcare Utilization (Psychiatric Medications, Hospitalizations, Cardiac Procedures, Outpatient Services)	Referred Care	4289.23	Standard Error 826.56	dollars
Cost for Healthcare Utilization (Psychiatric Medications, Hospitalizations, Cardiac Procedures, Outpatient Services)	Stepped Care	4358.02	Standard Error 883.76	dollars

Source ClinicalTrials.gov

Participant flow6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	Referred Care	77
Overall Study	STARTED	Stepped Care	73
Overall Study	COMPLETED	Referred Care	71
Overall Study	COMPLETED	Stepped Care	67
Overall Study	NOT COMPLETED	Referred Care	6
Overall Study	NOT COMPLETED	Stepped Care	6

Source ClinicalTrials.gov

Adverse events124

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk
other	Abdominal hernia	Injury, poisoning and procedural complications	Referred Care	0	77
other	Abdominal hernia	Injury, poisoning and procedural complications	Stepped Care	1	73
other	Worsened agitation	Psychiatric disorders	Referred Care	7	77
other	Worsened agitation	Psychiatric disorders	Stepped Care	4	73
other	Anemia	Blood and lymphatic system disorders	Referred Care	0	77
other	Anemia	Blood and lymphatic system disorders	Stepped Care	1	73
other	Worsened anxiety/nervousness	Psychiatric disorders	Referred Care	5	77
other	Worsened anxiety/nervousness	Psychiatric disorders	Stepped Care	4	73
other	Arthritis	Musculoskeletal and connective tissue disorders	Referred Care	0	77
other	Arthritis	Musculoskeletal and connective tissue disorders	Stepped Care	1	73

1 to 10 of 124Source ClinicalTrials.gov

See all 124 adverse events

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Referred Care
Total, all-cause mortality	Stepped Care
Total, other adverse events	Referred Care	63	77
Total, other adverse events	Stepped Care	59	73
Total, serious adverse events	Referred Care	8	77
Total, serious adverse events	Stepped Care	7	73

Source ClinicalTrials.gov

Papers1

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as
23471421	RESULT

Source PubMed

Grants1

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

Project	Title	Principal investigators	Organization	Funder	Fiscal years
RC2HL101663	Comparison of Depression Interventions after Acute Coronary Syndrome (CODIACS)	DAVIDSON, KARINA W.	COLUMBIA UNIVERSITY HEALTH SCIENCES	NATIONAL HEART, LUNG, AND BLOOD INSTITUTE	2009 to 2010

Source NIH RePORTER

Trial comparisons1

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison
Referred Care vs Stepped Care: serious adverse events

Source Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT01032018

GET https://conductscience.org/api/trials/v1/NCT01032018/events?page=2

API reference For AI assistants