Trial · NCT01042093
Efficacy of Multimodal Perioperative Analgesia With Periarticular Drug Injection in Total Knee Arthroplasty(TKA)
NCT01042093, Not applicable, Completed, Towson Orthopaedic Associates; results first posted 2013-11-08
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Efficacy of Multimodal Perioperative Analgesia With Periarticular Drug Injection in Total Knee Arthroplasty(TKA). Trials, record NCT01042093. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT01042093
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Efficacy of Multimodal Perioperative Analgesia With Periarticular Drug Injection in Total Knee Arthroplasty(TKA)
- NCT number
- NCT01042093
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 160 participants, actual
- Lead sponsor
- Towson Orthopaedic Associates
- Conditions
- Osteoarthritis,Knee
- Interventions
- Ropivacaine, Toradol, Clonidine, Epinephrine
- First posted
- 2010-01-05
- Last updated
- 2013-11-08
- Results first posted
- 2013-11-08
Source ClinicalTrials.gov
Registered outcomes3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Numerical Rating Scale (NRS) Pain Scores During Hospitalization. | 2 days after surgery | Patient pain was assessed during hospitalization using the VAS Pain Scale, a numerical rating scale ranging from 0 (no pain) to 10 (severe pain). A lower score represents a better outcome. Pain was assessed preoperatively, 1 hour postoperatively in the post anesthesia unit, and then every 8 hours on the Orthopedic inpatient unit, for a duration of 2 days. |
| Secondary | Narcotic Consumption During Hospitalization | 4 days | A variety of pain medications were used after surgery to keep patients comfortable. Narcotic use was recorded as morphine equivalents. We report the mean narcotic consumption for each group for the day of surgery as well as post operative day 1,2, and 3. |
| Secondary | Knee Society Pain Scores at 6 Week Follow-up Appointment | 6 weeks after surgery | Patients were assessed for pain at their 6 week follow-up appointment using the Knee Society Rating Scale. Using this scale patients are given a pain score ranging from 0 (severe pain) to 50 (No Pain). This is determined as follows: No pain/50 points, Mild or occasional pain/45 points, pain with stairs only/40 points, pain with walking and stairs/30 points, Moderate/occasional pain/ 20 points,continual pain/10 points, severe pain/0 points. We report the mean score for each group. A higher score represents a better outcome. |
Source ClinicalTrials.gov
Outcomes3
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Numerical Rating Scale (NRS) Pain Scores During Hospitalization. | 2 days after surgery | scores on a scale 0-10 | MEAN | |
| SECONDARY | Narcotic Consumption During Hospitalization | 4 days | mg | MEAN | |
| SECONDARY | Knee Society Pain Scores at 6 Week Follow-up Appointment | 6 weeks after surgery | Scores on a scale 0-50 | MEAN |
Source ClinicalTrials.gov
Results by group52
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Numerical Rating Scale (NRS) Pain Scores During Hospitalization. | ROP/EPI/TOR/CLO | Vas Pain Scale - 1 Hour Post Op | 1.06 | Standard Deviation 1.74 | scores on a scale 0-10 |
| Numerical Rating Scale (NRS) Pain Scores During Hospitalization. | ROP/EPI/TOR | Vas Pain Scale - 1 Hour Post Op | 1.90 | Standard Deviation 1.04 | scores on a scale 0-10 |
| Numerical Rating Scale (NRS) Pain Scores During Hospitalization. | ROP/EPI/CLO | Vas Pain Scale - 1 Hour Post Op | 2.67 | Standard Deviation 3.06 | scores on a scale 0-10 |
| Numerical Rating Scale (NRS) Pain Scores During Hospitalization. | ROP/EPI | Vas Pain Scale - 1 Hour Post Op | 1.60 | Standard Deviation 2.01 | scores on a scale 0-10 |
| Numerical Rating Scale (NRS) Pain Scores During Hospitalization. | ROP/EPI/TOR/CLO | Vas Pain Scale - 8 Hour Post Op | 1.52 | Standard Deviation 1.54 | scores on a scale 0-10 |
| Numerical Rating Scale (NRS) Pain Scores During Hospitalization. | ROP/EPI/TOR | Vas Pain Scale - 8 Hour Post Op | 1.52 | Standard Deviation 1.56 | scores on a scale 0-10 |
| Numerical Rating Scale (NRS) Pain Scores During Hospitalization. | ROP/EPI/CLO | Vas Pain Scale - 8 Hour Post Op | 3.93 | Standard Deviation 2.57 | scores on a scale 0-10 |
| Numerical Rating Scale (NRS) Pain Scores During Hospitalization. | ROP/EPI | Vas Pain Scale - 8 Hour Post Op | 2.82 | Standard Deviation 1.93 | scores on a scale 0-10 |
| Numerical Rating Scale (NRS) Pain Scores During Hospitalization. | ROP/EPI/TOR/CLO | Vas Pain Scale - 16 Hour Post Op | 1.85 | Standard Deviation 1.69 | scores on a scale 0-10 |
| Numerical Rating Scale (NRS) Pain Scores During Hospitalization. | ROP/EPI/TOR | Vas Pain Scale - 16 Hour Post Op | 2.22 | Standard Deviation 2.36 | scores on a scale 0-10 |
1 to 10 of 52Source ClinicalTrials.gov
See all 52 results by groupParticipant flow12
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | ROP/EPI/TOR/CLO | 40 | |
| Overall Study | STARTED | REP/EPI/TOR | 40 | |
| Overall Study | STARTED | REP/EPI/CLO | 40 | |
| Overall Study | STARTED | REP/EPI | 40 | |
| Overall Study | COMPLETED | ROP/EPI/TOR/CLO | 38 | |
| Overall Study | COMPLETED | REP/EPI/TOR | 38 | |
| Overall Study | COMPLETED | REP/EPI/CLO | 38 | |
| Overall Study | COMPLETED | REP/EPI | 36 | |
| Overall Study | NOT COMPLETED | ROP/EPI/TOR/CLO | 2 | |
| Overall Study | NOT COMPLETED | REP/EPI/TOR | 2 |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 participant flowAdverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals12
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | ROP/EPI/TOR/CLO | ||
| Total, all-cause mortality | ROP/EPI/TOR | ||
| Total, all-cause mortality | ROP/EPI/CLO | ||
| Total, all-cause mortality | ROP/EPI | ||
| Total, other adverse events | ROP/EPI/TOR/CLO | 0 | 40 |
| Total, other adverse events | ROP/EPI/TOR | 0 | 40 |
| Total, other adverse events | ROP/EPI/CLO | 0 | 40 |
| Total, other adverse events | ROP/EPI | 0 | 40 |
| Total, serious adverse events | ROP/EPI/TOR/CLO | 0 | 40 |
| Total, serious adverse events | ROP/EPI/TOR | 0 | 40 |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 adverse event totalsPapers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT01042093
GET https://conductscience.org/api/trials/v1/NCT01042093/results?page=2