Trial · NCT01067846
Cognitive Enhancement and Relapse Prevention in Cocaine Addiction
NCT01067846, Not applicable, Completed, University of Arkansas; results first posted 2013-11-26
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Cognitive Enhancement and Relapse Prevention in Cocaine Addiction. Trials, record NCT01067846. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT01067846
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Cognitive Enhancement and Relapse Prevention in Cocaine Addiction
- NCT number
- NCT01067846
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 85 participants, actual
- Lead sponsor
- University of Arkansas
- Conditions
- Cocaine Addiction
- Interventions
- Seromycin (D-cycloserine, DCS), Placebo, Computerized Cognitive Behavioral Therapy
- First posted
- 2010-02-12
- Last updated
- 2013-11-26
- Results first posted
- 2013-11-26
Source ClinicalTrials.gov
Registered outcomes2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Drug Abstinence During Treatment and at Follow up Visits | Participants provided urine samples for drug testing during treatment which occurred 3 times per week for 4 weeks, at the end of treatment, and at a 1 and 2 month follow up visit | Percentage of the overall number of drug abstinences of participants measured by urine drug testing |
| Primary | Treatment Retention - Number of Visits During Treatment | Treatment sessions included 3 visits per week for 4 weeks | Number of treatment visits attended prior to discontinuation of treatment |
Source ClinicalTrials.gov
Outcomes2
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Drug Abstinence During Treatment and at Follow up Visits | Participants provided urine samples for drug testing during treatment which occurred 3 times per week for 4 weeks, at the end of treatment, and at a 1 and 2 month follow up visit | Total possible urine samples = 225 per arm. Not all participants stayed in treatment, therefore the total units analyzed will not match the total possible. | percentage of drug abstinences | NUMBER |
| PRIMARY | Treatment Retention - Number of Visits During Treatment | Treatment sessions included 3 visits per week for 4 weeks | Total possible sessions attended = 180 per arm. Some participants did not complete all sessions, therefore the units analyzed will not match the total possible. | visits | MEAN |
Source ClinicalTrials.gov
Results by group4
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Drug Abstinence During Treatment and at Follow up Visits | DCS and Cognitive Behavioral Therapy | 12 | percentage of drug abstinences | ||
| Drug Abstinence During Treatment and at Follow up Visits | Placebo and Cognitive Behavioral Therapy | 25 | percentage of drug abstinences | ||
| Treatment Retention - Number of Visits During Treatment | DCS and Cognitive Behavioral Therapy | 10 | Standard Deviation 3 | visits | |
| Treatment Retention - Number of Visits During Treatment | Placebo and Cognitive Behavioral Therapy | 10 | Standard Deviation 3 | visits |
Source ClinicalTrials.gov
Participant flow8
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | DCS and Cognitive Behavioral Therapy | 29 | |
| Overall Study | STARTED | Placebo and Cognitive Behavioral Therapy | 30 | |
| Overall Study | Completed 3 Tx Sessions | DCS and Cognitive Behavioral Therapy | 15 | |
| Overall Study | Completed 3 Tx Sessions | Placebo and Cognitive Behavioral Therapy | 15 | |
| Overall Study | COMPLETED | DCS and Cognitive Behavioral Therapy | 10 | |
| Overall Study | COMPLETED | Placebo and Cognitive Behavioral Therapy | 11 | |
| Overall Study | NOT COMPLETED | DCS and Cognitive Behavioral Therapy | 19 | |
| Overall Study | NOT COMPLETED | Placebo and Cognitive Behavioral Therapy | 19 |
Source ClinicalTrials.gov
Adverse events10
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| other | cough | Respiratory, thoracic and mediastinal disorders | DCS and Cognitive Behavioral Therapy | 1 | 29 | 1 |
| other | cough | Respiratory, thoracic and mediastinal disorders | Placebo and Cognitive Behavioral Therapy | 0 | 30 | 0 |
| other | headache | Nervous system disorders | DCS and Cognitive Behavioral Therapy | 1 | 29 | 1 |
| other | headache | Nervous system disorders | Placebo and Cognitive Behavioral Therapy | 0 | 30 | 0 |
| other | nausea | General disorders | DCS and Cognitive Behavioral Therapy | 1 | 29 | 1 |
| other | nausea | General disorders | Placebo and Cognitive Behavioral Therapy | 0 | 30 | 0 |
| other | sensation on skin | Skin and subcutaneous tissue disorders | DCS and Cognitive Behavioral Therapy | 0 | 29 | 0 |
| other | sensation on skin | Skin and subcutaneous tissue disorders | Placebo and Cognitive Behavioral Therapy | 1 | 30 | 2 |
| other | rash on skin | Skin and subcutaneous tissue disorders | DCS and Cognitive Behavioral Therapy | 0 | 29 | 0 |
| other | rash on skin | Skin and subcutaneous tissue disorders | Placebo and Cognitive Behavioral Therapy | 1 | 30 | 2 |
Source ClinicalTrials.gov
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | DCS and Cognitive Behavioral Therapy | ||
| Total, all-cause mortality | Placebo and Cognitive Behavioral Therapy | ||
| Total, other adverse events | DCS and Cognitive Behavioral Therapy | 3 | 29 |
| Total, other adverse events | Placebo and Cognitive Behavioral Therapy | 2 | 30 |
| Total, serious adverse events | DCS and Cognitive Behavioral Therapy | 0 | 29 |
| Total, serious adverse events | Placebo and Cognitive Behavioral Therapy | 0 | 30 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| R21DA025243 | The Clinical and Neural Response of Cocaine Addicts to Combination Treatment with | KILTS, CLINTON D | UNIV OF ARKANSAS FOR MED SCIS | NATIONAL INSTITUTE ON DRUG ABUSE | 2008 to 2009 |
Source NIH RePORTER
Trial comparisons1
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison |
|---|
| DCS and Cognitive Behavioral Therapy vs Placebo and Cognitive Behavioral Therapy: serious adverse events |
Source Trial comparisons
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT01067846
GET https://conductscience.org/api/trials/v1/NCT01067846/registered