Effect of Febuxostat on Renal Function in Patients With Gout and Moderate to Severe Renal Impairment
Trial · NCT01082640
Results by group21
Each measurement the trial posted, group by group, in the words and numbers it posted.
1 to 20 of 21
Download this page as JSON| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Change From Baseline to Month 12 in Serum Creatinine | Placebo | Baseline | 2.52 | Standard Error 0.126 | mg/dL |
| Change From Baseline to Month 12 in Serum Creatinine | Febuxostat 30 mg BID | Baseline | 2.10 | Standard Error 0.126 | mg/dL |
| Change From Baseline to Month 12 in Serum Creatinine | Febuxostat 40/80 mg QD | Baseline | 2.22 | Standard Error 0.128 | mg/dL |
| Change From Baseline to Month 12 in Serum Creatinine | Placebo | Change from Baseline at Month 12 | 0.19 | Standard Error 0.094 | mg/dL |
| Change From Baseline to Month 12 in Serum Creatinine | Febuxostat 30 mg BID | Change from Baseline at Month 12 | 0.09 | Standard Error 0.093 | mg/dL |
| Change From Baseline to Month 12 in Serum Creatinine | Febuxostat 40/80 mg QD | Change from Baseline at Month 12 | 0.23 | Standard Error 0.094 | mg/dL |
| Change From Baseline to Month 12 in Estimated Glomerular Filtration Rate (eGFR) | Placebo | Baseline | 29.31 | Standard Error 1.461 | mL/min/1.73m² |
| Change From Baseline to Month 12 in Estimated Glomerular Filtration Rate (eGFR) | Febuxostat 30 mg BID | Baseline | 34.14 | Standard Error 1.461 | mL/min/1.73m² |
| Change From Baseline to Month 12 in Estimated Glomerular Filtration Rate (eGFR) | Febuxostat 40/80 mg QD | Baseline | 34.08 | Standard Error 1.484 | mL/min/1.73m² |
| Change From Baseline to Month 12 in Estimated Glomerular Filtration Rate (eGFR) | Placebo | Change from Baseline at Month 12 | -2.05 | Standard Error 1.198 | mL/min/1.73m² |
| Change From Baseline to Month 12 in Estimated Glomerular Filtration Rate (eGFR) | Febuxostat 30 mg BID | Change from Baseline at Month 12 | 0.33 | Standard Error 1.172 | mL/min/1.73m² |
| Change From Baseline to Month 12 in Estimated Glomerular Filtration Rate (eGFR) | Febuxostat 40/80 mg QD | Change from Baseline at Month 12 | -0.86 | Standard Error 0.190 | mL/min/1.73m² |
| Percentage of Participants With Serum Urate (sUA) Less Than 6 mg/dL at Month 12 | Placebo | 0 | percentage of participants | ||
| Percentage of Participants With Serum Urate (sUA) Less Than 6 mg/dL at Month 12 | Febuxostat 30 mg BID | 68.8 | percentage of participants | ||
| Percentage of Participants With Serum Urate (sUA) Less Than 6 mg/dL at Month 12 | Febuxostat 40/80 mg QD | 45.2 | percentage of participants | ||
| Mean Clearance (CL/F) of Febuxostat at Steady State | Febuxostat 30 mg BID | 8.16 | Standard Deviation 2.31 | liters/hour | |
| Mean Clearance (CL/F) of Febuxostat at Steady State | Febuxostat 40 mg QD | 8.71 | Standard Deviation 2.21 | liters/hour | |
| Mean Clearance (CL/F) of Febuxostat at Steady State | Febuxostat 80 mg QD | 10.9 | Standard Deviation 4.70 | liters/hour | |
| Mean Area Under the Concentration-Time Curve During the Dosing Interval (AUC[0-τ]) of Febuxostat at Steady State | Febuxostat 30 mg BID | 3.98 | Standard Deviation 1.21 | hr*µg/mL | |
| Mean Area Under the Concentration-Time Curve During the Dosing Interval (AUC[0-τ]) of Febuxostat at Steady State | Febuxostat 40 mg QD | 4.91 | Standard Deviation 1.29 | hr*µg/mL |
Source ClinicalTrials.govtrials-2026-11-12-0.5.0
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this list from software.
Twenty rows a page, as JSON. No key.
GET https://conductscience.org/api/trials/v1/NCT01082640/results