Trial · NCT01110434

Biobehavioral Effects of Topiramate on Cannabis-Related Outcomes in Adolescents

NCT01110434, Phase 2, Completed, Brown University; results first posted 2020-09-16

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Biobehavioral Effects of Topiramate on Cannabis-Related Outcomes in Adolescents. Trials, record NCT01110434. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT01110434

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Biobehavioral Effects of Topiramate on Cannabis-Related Outcomes in Adolescents
NCT number: NCT01110434
Status: Completed
Phases: Phase 2
Enrollment: 66 participants, actual
Lead sponsor: Brown University
Conditions: Cannabis Abuse, Cannabis Dependence
Interventions: Topiramate, Placebo
First posted: 2010-04-26
Last updated: 2020-09-16
Results first posted: 2020-09-16

Source ClinicalTrials.gov

Registered outcomes3

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Cannabis Use	Weeks 1-6	Frequency of Cannabis Use (Percent Use Days Per Week)
Secondary	Quantity of Cannabis Use	Weeks 1-6	Total Grams of Cannabis Use Per week
Secondary	Amount of Cannabis Use Per Use Day	Weeks 1-6	Average Grams of Cannabis Used Per Use Day

Source ClinicalTrials.gov

Outcomes3

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Units	Measured as
PRIMARY	Cannabis Use	Weeks 1-6	Percentage of use days	MEAN
SECONDARY	Quantity of Cannabis Use	Weeks 1-6	Grams Per Week	MEAN
SECONDARY	Amount of Cannabis Use Per Use Day	Weeks 1-6	Average Grams Per Use Day	MEAN

Source ClinicalTrials.gov

Results by group6

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Spread	Units
Cannabis Use	Topiramate	55.89	Standard Deviation 32.35	Percentage of use days
Cannabis Use	Sugar Pill	63.10	Standard Deviation 34.91	Percentage of use days
Quantity of Cannabis Use	Topiramate	1.87	Standard Deviation 2.11	Grams Per Week
Quantity of Cannabis Use	Sugar Pill	2.85	Standard Deviation 3.29	Grams Per Week
Amount of Cannabis Use Per Use Day	Topiramate	0.46	Standard Deviation 0.32	Average Grams Per Use Day
Amount of Cannabis Use Per Use Day	Sugar Pill	0.60	Standard Deviation 0.48	Average Grams Per Use Day

Source ClinicalTrials.gov

Participant flow6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	Topiramate	40
Overall Study	STARTED	Sugar Pill	26
Overall Study	COMPLETED	Topiramate	29
Overall Study	COMPLETED	Sugar Pill	20
Overall Study	NOT COMPLETED	Topiramate	11
Overall Study	NOT COMPLETED	Sugar Pill	6

Source ClinicalTrials.gov

Adverse events52

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk
other	Headache	General disorders	Topiramate	8	40
other	Headache	General disorders	Sugar Pill	6	26
other	Rash	Skin and subcutaneous tissue disorders	Topiramate	0	40
other	Rash	Skin and subcutaneous tissue disorders	Sugar Pill	3	26
other	Cough, Cold Symptoms	General disorders	Topiramate	5	40
other	Cough, Cold Symptoms	General disorders	Sugar Pill	5	26
other	Injury	General disorders	Topiramate	8	40
other	Injury	General disorders	Sugar Pill	5	26
other	Parasthesias	General disorders	Topiramate	15	40
other	Parasthesias	General disorders	Sugar Pill	2	26

1 to 10 of 52Source ClinicalTrials.gov

See all 52 adverse events

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Topiramate	0	40
Total, all-cause mortality	Sugar Pill	0	26
Total, other adverse events	Topiramate	35	40
Total, other adverse events	Sugar Pill	24	26
Total, serious adverse events	Topiramate	0	40
Total, serious adverse events	Sugar Pill	0	26

Source ClinicalTrials.gov

Papers2

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as	Source
29672090	DERIVED	PubMed
34014688	DERIVED	PubMed

Grants1

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

Project	Title	Principal investigators	Organization	Funder	Fiscal years
R01DA026778	Biobehavioral effects of topiramate on cannabis-related outcomes in adolescents	MIRANDA, ROBERT	BROWN UNIVERSITY	NATIONAL INSTITUTE ON DRUG ABUSE	2009 to 2010

Source NIH RePORTER

Trial comparisons2

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
Topiramate vs Sugar Pill: deaths from any cause	Trial comparisons
Topiramate vs Sugar Pill: serious adverse events	Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT01110434

GET https://conductscience.org/api/trials/v1/NCT01110434/events?page=2

API reference For AI assistants