Trial · NCT01212874
Esmolol or Nitroglycerin Infusion for Blood Pressure Control Prior to Cardiopulmonary Bypass (CPB) in Cardiac Surgery
NCT01212874, Not applicable, Completed, Loma Linda University; results first posted 2016-08-17
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Esmolol or Nitroglycerin Infusion for Blood Pressure Control Prior to Cardiopulmonary Bypass (CPB) in Cardiac Surgery. Trials, record NCT01212874. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT01212874
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Esmolol or Nitroglycerin Infusion for Blood Pressure Control Prior to Cardiopulmonary Bypass (CPB) in Cardiac Surgery
- NCT number
- NCT01212874
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 70 participants, actual
- Lead sponsor
- Loma Linda University
- Conditions
- Hypertension
- Interventions
- nitroglycerin, esmolol
- First posted
- 2010-10-01
- Last updated
- 2019-03-01
- Results first posted
- 2016-08-17
- Limitations and caveats
- Only 25 of 70 patients received the assigned intervention. Individualized BP ranges based on day of surgery measurement likely decreased treatment.
Source ClinicalTrials.gov
Registered outcomes2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Diastolic Blood Pressure Excursions Beyond Predetermined Lower Limits, Normalized Per Hour | Participants were followed from Anesthesia Induction to Initiation of Cardiopulmonary Bypass, an average of 5 hours | Area under the curve (AUC) of Diastolic Blood Pressure Excursions Beyond Predetermined Lower Limits, Normalized Per Hour from Anesthesia Induction to Initiation of Cardiopulmonary Bypass |
| Secondary | Title: Systolic Hypertension | Participants were followed from Anesthesia Induction to Initiation of Cardiopulmonary Bypass, an average of 5 hours | Area under the curve (AUC) of Systolic Blood Pressure Excursions Beyond Predetermined Upper Limits, Normalized Per Hour from Anesthesia Induction to Initiation of Cardiopulmonary Bypass |
Source ClinicalTrials.gov
Outcomes2
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Diastolic Blood Pressure Excursions Beyond Predetermined Lower Limits, Normalized Per Hour | Participants were followed from Anesthesia Induction to Initiation of Cardiopulmonary Bypass, an average of 5 hours | Data capture failure lost data from 2 treated patients in each group; these were thus excluded from analysis. | mmHg*min/prebypass hour | MEDIAN |
| SECONDARY | Title: Systolic Hypertension | Participants were followed from Anesthesia Induction to Initiation of Cardiopulmonary Bypass, an average of 5 hours | Data capture failure lost data from 2 treated patients in each group; these were thus excluded from analysis. | mmHg*min / prebypass hour | MEDIAN |
Source ClinicalTrials.gov
Results by group4
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Diastolic Blood Pressure Excursions Beyond Predetermined Lower Limits, Normalized Per Hour | Esmolol | 97.9 | 95% Confidence Interval 47.7 to 181.4 | mmHg*min/prebypass hour | |
| Diastolic Blood Pressure Excursions Beyond Predetermined Lower Limits, Normalized Per Hour | Nitroglycerin | 45.6 | 95% Confidence Interval 21.0 to 93.9 | mmHg*min/prebypass hour | |
| Title: Systolic Hypertension | Esmolol | 48.6 | 95% Confidence Interval 18.2 to 90.8 | mmHg*min / prebypass hour | |
| Title: Systolic Hypertension | Nitroglycerin | 145.8 | 95% Confidence Interval 79.4 to 259.9 | mmHg*min / prebypass hour |
Source ClinicalTrials.gov
Participant flow8
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Esmolol | 35 | |
| Overall Study | STARTED | Nitroglycerin | 35 | |
| Overall Study | Received Allocated Intervention | Esmolol | 13 | |
| Overall Study | Received Allocated Intervention | Nitroglycerin | 12 | |
| Overall Study | COMPLETED | Esmolol | 13 | |
| Overall Study | COMPLETED | Nitroglycerin | 12 | |
| Overall Study | NOT COMPLETED | Esmolol | 22 | |
| Overall Study | NOT COMPLETED | Nitroglycerin | 23 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Esmolol | ||
| Total, all-cause mortality | Nitroglycerin | ||
| Total, other adverse events | Esmolol | 0 | 35 |
| Total, other adverse events | Nitroglycerin | 0 | 35 |
| Total, serious adverse events | Esmolol | 0 | 35 |
| Total, serious adverse events | Nitroglycerin | 0 | 35 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons1
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison |
|---|
| Esmolol vs Nitroglycerin: serious adverse events |
Source Trial comparisons
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT01212874
GET https://conductscience.org/api/trials/v1/NCT01212874/registered