Trial · NCT01238185
Aspirin Mouthwash in Treating Patients With Oral Leukoplakia
NCT01238185, Phase 1, Completed, Institute of Head and Neck Studies and Education, United Kingdom
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Aspirin Mouthwash in Treating Patients With Oral Leukoplakia. Trials, record NCT01238185. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT01238185
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Aspirin Mouthwash in Treating Patients With Oral Leukoplakia
- NCT number
- NCT01238185
- Status
- Completed
- Phases
- Phase 1
- Enrollment
- 40 participants, estimated
- Lead sponsor
- Institute of Head and Neck Studies and Education, United Kingdom
- Conditions
- Precancerous Condition
- Interventions
- acetylsalicylic acid, gene expression analysis, protein expression analysis, laboratory biomarker analysis, questionnaire administration, biopsy
- First posted
- 2010-11-10
- Last updated
- 2013-08-12
- Other registries' IDs
- isrctn:ISRCTN31503555
Source ClinicalTrials.gov
Registered outcomes8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | PGE2 levels as assessed by enzyme immunosorbent assay | ||
| Primary | COX-1 and COX-2 mRNA as assessed by qRT-PCR | ||
| Primary | COX-1 and COX-2 protein expression as assessed by immunohistochemistry and quantified by immunoblotting to determine whether COX inhibition in oral dysplasia tissues is actually possible by use of the mouthwash formulation | ||
| Secondary | Comparison of WHO histological grade and clinical size of dysplastic lesions before and after treatment and assessment of proliferating cell nuclear antigen | ||
| Secondary | Tolerability and possible oral and other adverse effects using a questionnaire | ||
| Secondary | VEGF mRNA expression as assessed by qRT-PCR | ||
| Secondary | Protein expression as assessed by ELISA and immunohistochemistry for VEGFA | ||
| Secondary | Global gene response of dysplastic tissue as assessed by Affymetrix gene expression microarrays |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT01238185
GET https://conductscience.org/api/trials/v1/NCT01238185/registered