Effects of Strengthening Exercise on the Brain for Early Dementia and Normative Older Adults
NCT01264614, Not applicable, Completed, Union College, New York; results first posted 2015-03-11
Trial 11
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Effects of Strengthening Exercise on the Brain for Early Dementia and Normative Older Adults | ClinicalTrials.gov |
| NCT number | NCT01264614 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 22 participants, actual | ClinicalTrials.gov |
| Lead sponsor | Union College, New York | ClinicalTrials.gov |
| Conditions | Cognitive Decline, Dementia, Alzheimer's Disease, Mild Cognitive Impairment | ClinicalTrials.gov |
| Interventions | Strengthening exercise | ClinicalTrials.gov |
| First posted | 2010-12-22 | ClinicalTrials.gov |
| Last updated | 2015-03-11 | ClinicalTrials.gov |
| Results first posted | 2015-03-11 | ClinicalTrials.gov |
Registered outcomes 6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Stroop Test Performance From Pre- to Post-intervention | Baseline and 3 months | Average raw cognitive scores before (T1) and after (T2) strengthening exercise intervention. Lower scores on Stroop C (possible range 0-240 sec) represents better performance). | ClinicalTrials.gov |
| Primary | Digits Backwards Test Performance From Pre- to Post-intervention | Baseline and 3 months | Average raw cognitive scores before (T1) and after (T2) strengthening exercise intervention. Higher scores represent better performance (Digits backwards possible score range is 0-14 points). | ClinicalTrials.gov |
| Primary | Color Trails Test Performance From Pre- to Post-intervention | Baseline and 3 months | Average raw cognitive scores before (T1) and after (T2) strengthening exercise intervention. Higher scores represent better performance (Color Trails possible score range is 0-300 seconds). | ClinicalTrials.gov |
| Primary | Fuld Test Performance From Pre- to Post-intervention | Baseline and 3 months | Average raw cognitive scores before (T1) and after (T2) strengthening exercise intervention. Higher scores represent better performance (Fuld Semantic Recall possible score range is 0-20 points; Fuld Immediate and Delayed Recall possible score range is 0-10). | ClinicalTrials.gov |
| Primary | Figure Copy & Delayed Test Performance From Pre- to Post-intervention | Baseline and 3 months | Average raw cognitive scores before (T1) and after (T2) strengthening exercise intervention. Higher scores represent better performance (Figure Copy \& Delayed possible score range is 0-36 points). | ClinicalTrials.gov |
| Primary | Neurophysiological Function Pre- & Post- Intervention | Baseline and 3 months | Resting EEG and ERP recordings before (T1) and after (T2) strengthening exercise intervention | ClinicalTrials.gov |
Outcomes 6
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|---|---|---|---|---|---|
| PRIMARY | Stroop Test Performance From Pre- to Post-intervention | Baseline and 3 months | Two of 9 normative participants, had to be dropped from analyses due to limited participation in the exercise program (less than once per week on average; health problems and snowy weather were the main limiting factors) and one dementia exerciser was dropped because he did not complete any of the outcome measures. | Time to complete (seconds) | MEAN | ClinicalTrials.gov |
| PRIMARY | Digits Backwards Test Performance From Pre- to Post-intervention | Baseline and 3 months | Two of 9 normative participants, had to be dropped from analyses due to limited participation in the exercise program (less than once per week on average; health problems and snowy weather were the main limiting factors) and one dementia exerciser was dropped because he did not complete any of the outcome measures. | Points | MEAN | ClinicalTrials.gov |
| PRIMARY | Color Trails Test Performance From Pre- to Post-intervention | Baseline and 3 months | Two of 9 normative participants, had to be dropped from analyses due to limited participation in the exercise program (less than once per week on average; health problems and snowy weather were the main limiting factors) and one dementia exerciser was dropped because he did not complete any of the outcome measures. | Time to complete (seconds) | MEAN | ClinicalTrials.gov |
| PRIMARY | Fuld Test Performance From Pre- to Post-intervention | Baseline and 3 months | Two of 9 normative participants, had to be dropped from analyses due to limited participation in the exercise program (less than once per week on average; health problems and snowy weather were the main limiting factors) and one dementia exerciser was dropped because he did not complete any of the outcome measures. | Points | MEAN | ClinicalTrials.gov |
| PRIMARY | Figure Copy & Delayed Test Performance From Pre- to Post-intervention | Baseline and 3 months | Two of 9 normative participants, had to be dropped from analyses due to limited participation in the exercise program (less than once per week on average; health problems and snowy weather were the main limiting factors) and one dementia exerciser was dropped because he did not complete any of the outcome measures. | Points | MEAN | ClinicalTrials.gov |
| PRIMARY | Neurophysiological Function Pre- & Post- Intervention | Baseline and 3 months | ClinicalTrials.gov |
Results by group 32
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|---|---|---|---|---|---|
| Stroop Test Performance From Pre- to Post-intervention | Early Stage Dementia | Stroop C pre | 137.67 | Standard Deviation 102.30 | Time to complete (seconds) | ClinicalTrials.gov |
| Stroop Test Performance From Pre- to Post-intervention | Normative Older Adults | Stroop C pre | 56.17 | Standard Deviation 10.34 | Time to complete (seconds) | ClinicalTrials.gov |
| Stroop Test Performance From Pre- to Post-intervention | Early Stage Dementia | Stroop C post | 116.51 | Standard Deviation 64.44 | Time to complete (seconds) | ClinicalTrials.gov |
| Stroop Test Performance From Pre- to Post-intervention | Normative Older Adults | Stroop C post | 55.13 | Standard Deviation 11.08 | Time to complete (seconds) | ClinicalTrials.gov |
| Digits Backwards Test Performance From Pre- to Post-intervention | Early Stage Dementia | Digits Backward pre | 4.10 | Standard Deviation 1.73 | Points | ClinicalTrials.gov |
| Digits Backwards Test Performance From Pre- to Post-intervention | Normative Older Adults | Digits Backward pre | 5.50 | Standard Deviation 2.59 | Points | ClinicalTrials.gov |
| Digits Backwards Test Performance From Pre- to Post-intervention | Early Stage Dementia | Digits Backward post | 3.90 | Standard Deviation 1.10 | Points | ClinicalTrials.gov |
| Digits Backwards Test Performance From Pre- to Post-intervention | Normative Older Adults | Digits Backward post | 6.83 | Standard Deviation 2.71 | Points | ClinicalTrials.gov |
| Color Trails Test Performance From Pre- to Post-intervention | Early Stage Dementia | Color Trails 2 pre | 250.00 | Standard Deviation 186.45 | Time to complete (seconds) | ClinicalTrials.gov |
| Color Trails Test Performance From Pre- to Post-intervention | Normative Older Adults | Color Trails 2 pre | 124.00 | Standard Deviation 67.97 | Time to complete (seconds) | ClinicalTrials.gov |
| Color Trails Test Performance From Pre- to Post-intervention | Early Stage Dementia | Color Trails 2 post | 259.01 | Standard Deviation 197.63 | Time to complete (seconds) | ClinicalTrials.gov |
| Color Trails Test Performance From Pre- to Post-intervention | Normative Older Adults | Color Trails 2 post | 96.11 | Standard Deviation 19.97 | Time to complete (seconds) | ClinicalTrials.gov |
| Fuld Test Performance From Pre- to Post-intervention | Early Stage Dementia | Fuld Semantic Recall pre | 10.60 | Standard Deviation 3.66 | Points | ClinicalTrials.gov |
| Fuld Test Performance From Pre- to Post-intervention | Normative Older Adults | Fuld Semantic Recall pre | 18.80 | Standard Deviation 8.76 | Points | ClinicalTrials.gov |
| Fuld Test Performance From Pre- to Post-intervention | Early Stage Dementia | Fuld Semantic Recall post | 10.60 | Standard Deviation 4.27 | Points | ClinicalTrials.gov |
| Fuld Test Performance From Pre- to Post-intervention | Normative Older Adults | Fuld Semantic Recall post | 18.60 | Standard Deviation 5.86 | Points | ClinicalTrials.gov |
| Fuld Test Performance From Pre- to Post-intervention | Early Stage Dementia | Fuld Immediate Recall pre | 2.90 | Standard Deviation 2.38 | Points | ClinicalTrials.gov |
| Fuld Test Performance From Pre- to Post-intervention | Normative Older Adults | Fuld Immediate Recall pre | 6.60 | Standard Deviation 1.34 | Points | ClinicalTrials.gov |
| Fuld Test Performance From Pre- to Post-intervention | Early Stage Dementia | Fuld Immediate Recall post | 4.40 | Standard Deviation 1.65 | Points | ClinicalTrials.gov |
| Fuld Test Performance From Pre- to Post-intervention | Normative Older Adults | Fuld Immediate Recall post | 7.60 | Standard Deviation 1.52 | Points | ClinicalTrials.gov |
Participant flow 6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|---|---|---|---|---|
| Overall Study | STARTED | Early Stage Dementia | 13 | ClinicalTrials.gov | |
| Overall Study | STARTED | Normative Older Adults | 9 | ClinicalTrials.gov | |
| Overall Study | COMPLETED | Early Stage Dementia | 12 | ClinicalTrials.gov | |
| Overall Study | COMPLETED | Normative Older Adults | 7 | ClinicalTrials.gov | |
| Overall Study | NOT COMPLETED | Early Stage Dementia | 1 | ClinicalTrials.gov | |
| Overall Study | NOT COMPLETED | Normative Older Adults | 2 | ClinicalTrials.gov |
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 6
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|---|---|---|---|
| Total, all-cause mortality | Early Stage Dementia | ClinicalTrials.gov | ||
| Total, all-cause mortality | Normative Older Adults | ClinicalTrials.gov | ||
| Total, other adverse events | Early Stage Dementia | 0 | 13 | ClinicalTrials.gov |
| Total, other adverse events | Normative Older Adults | 0 | 9 | ClinicalTrials.gov |
| Total, serious adverse events | Early Stage Dementia | 0 | 13 | ClinicalTrials.gov |
| Total, serious adverse events | Normative Older Adults | 0 | 9 | ClinicalTrials.gov |
Papers 1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|---|---|
| 22136405 | RESULT | PubMed |
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 1
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Early Stage Dementia vs Normative Older Adults: serious adverse events | Trial comparisons |
Tests 1
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Stroop Color-Word Test | Primary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)