Trial · NCT01275729
The Effect of Loop Diuretics on Severity and Outcome of Acute Kidney Injury
NCT01275729, Not applicable, Completed, University of Chicago; results first posted 2023-07-07
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. The Effect of Loop Diuretics on Severity and Outcome of Acute Kidney Injury. Trials, record NCT01275729. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT01275729
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- The Effect of Loop Diuretics on Severity and Outcome of Acute Kidney Injury
- NCT number
- NCT01275729
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 96 participants, actual
- Lead sponsor
- University of Chicago
- Conditions
- Acute Kidney Failure
- Interventions
- Furosemide
- First posted
- 2011-01-12
- Last updated
- 2023-07-07
- Results first posted
- 2023-07-07
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Progression to Stage 3 AKI | within 7 days of furosemide administration | The number of patients who progressed to Stage 3 during the time of observation |
| Primary | Receipt of Renal Replacement Therapy (RRT) | within 7 days of furosemide administration | The number of patients who received renal replacement therapy (Dialysis) |
| Primary | Death | During the index hospital stay, an average of 17 days, until hospital discharge, or until death, whatever occurs first | Inpatient mortality |
| Secondary | Length of Intensive Care Unit (ICU) Stay | During the index hospital stay, an average of 9 days, until ICU discharge, or until death, whatever occurs first | duration if ICU stay for all patients |
| Secondary | Length of Hospital Stay | During the index hospital stay, an average of 17 days, until hospital discharge, or until death, whatever occurs first | duration of the total hospital Stay for all patients |
Source ClinicalTrials.gov
Outcomes5
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Progression to Stage 3 AKI | within 7 days of furosemide administration | Participants | COUNT_OF_PARTICIPANTS | |
| PRIMARY | Receipt of Renal Replacement Therapy (RRT) | within 7 days of furosemide administration | Participants | COUNT_OF_PARTICIPANTS | |
| PRIMARY | Death | During the index hospital stay, an average of 17 days, until hospital discharge, or until death, whatever occurs first | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Length of Intensive Care Unit (ICU) Stay | During the index hospital stay, an average of 9 days, until ICU discharge, or until death, whatever occurs first | days | MEAN | |
| SECONDARY | Length of Hospital Stay | During the index hospital stay, an average of 17 days, until hospital discharge, or until death, whatever occurs first | days | MEAN |
Source ClinicalTrials.gov
Results by group5
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Progression to Stage 3 AKI | Lasix | 23 | Participants | ||
| Receipt of Renal Replacement Therapy (RRT) | Lasix | 10 | Participants | ||
| Death | Lasix | 16 | Participants | ||
| Length of Intensive Care Unit (ICU) Stay | Lasix | 9.15 | Standard Error 1.45 | days | |
| Length of Hospital Stay | Lasix | 17.29 | Standard Error 2.4 | days |
Source ClinicalTrials.gov
Participant flow3
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Lasix | 96 | |
| Overall Study | COMPLETED | Lasix | 92 | |
| Overall Study | NOT COMPLETED | Lasix | 4 |
Source ClinicalTrials.gov
Adverse events3
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| other | Hypotension- defined requiring intervention by means of fluid administration or vasopressor support | Cardiac disorders | Lasix | 9 | 92 | |
| other | Hypokalemia | Metabolism and nutrition disorders | Lasix | 5 | 92 | |
| other | Hypomagnesemia | Metabolism and nutrition disorders | Lasix | 5 | 92 |
Source ClinicalTrials.gov
Adverse event totals3
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Lasix | 16 | 92 |
| Total, other adverse events | Lasix | 19 | 92 |
| Total, serious adverse events | Lasix | 0 | 92 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT01275729
GET https://conductscience.org/api/trials/v1/NCT01275729/registered