Trial · NCT01381016
Estrogen Sensitivity and Ovulatory Dysfunction in Obesity
NCT01381016, Not applicable, Completed, University of Colorado, Denver; results first posted 2015-02-18
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Estrogen Sensitivity and Ovulatory Dysfunction in Obesity. Trials, record NCT01381016. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT01381016
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Estrogen Sensitivity and Ovulatory Dysfunction in Obesity
- NCT number
- NCT01381016
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 30 participants, actual
- Lead sponsor
- University of Colorado, Denver
- Conditions
- Obesity, Infertility
- Interventions
- Estradiol, Gonadotropin-releasing hormone (GnRH), Progesterone
- First posted
- 2011-06-27
- Last updated
- 2015-04-20
- Results first posted
- 2015-02-18
Source ClinicalTrials.gov
Registered outcomes2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Luteinizing Hormone Pulse Amplitude | Baseline | The study is powered on luteinizing hormone pulse amplitude because it is the clinical outcome for which the most data is available. The primary comparison is whether there is a significant reduction in the pulse amplitude in the obese between the pre- and post-treatment periods and whether there is no change in the pulse amplitude in the normal weight patients between the pre and post-treatment periods. |
| Primary | Luteinizing Hormone Pulse Amplitude | Post estradiol at one month |
Source ClinicalTrials.gov
Outcomes2
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Luteinizing Hormone Pulse Amplitude | Baseline | IU/L | MEAN | |
| PRIMARY | Luteinizing Hormone Pulse Amplitude | Post estradiol at one month | IU/L | MEAN |
Source ClinicalTrials.gov
Results by group4
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Luteinizing Hormone Pulse Amplitude | Group 1 - Normal Weight | 2.73 | Standard Error .46 | IU/L | |
| Luteinizing Hormone Pulse Amplitude | Group 2 - Obese | 1.12 | Standard Error .19 | IU/L | |
| Luteinizing Hormone Pulse Amplitude | Control | 2.18 | Standard Error .4 | IU/L | |
| Luteinizing Hormone Pulse Amplitude | Experimental | 1.59 | Standard Error .29 | IU/L |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Control | 13 | |
| Overall Study | STARTED | Experimental | 17 | |
| Overall Study | COMPLETED | Control | 10 | |
| Overall Study | COMPLETED | Experimental | 11 | |
| Overall Study | NOT COMPLETED | Control | 3 | |
| Overall Study | NOT COMPLETED | Experimental | 6 |
Source ClinicalTrials.gov
Adverse events2
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| serious | Pregnancy | Pregnancy, puerperium and perinatal conditions | Control | 0 | 11 | 0 |
| serious | Pregnancy | Pregnancy, puerperium and perinatal conditions | Experimental | 1 | 15 | 1 |
Source ClinicalTrials.gov
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Control | ||
| Total, all-cause mortality | Experimental | ||
| Total, other adverse events | Control | 0 | 11 |
| Total, other adverse events | Experimental | 0 | 15 |
| Total, serious adverse events | Control | 0 | 11 |
| Total, serious adverse events | Experimental | 1 | 15 |
Source ClinicalTrials.gov
Papers3
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons1
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison |
|---|
| Experimental vs Control: serious adverse events |
Source Trial comparisons
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT01381016
GET https://conductscience.org/api/trials/v1/NCT01381016/registered