Trial · NCT01402492

Cocaine Use Reduction With Buprenorphine

NCT01402492, Phase 2, Phase 3, Completed, University of California, Los Angeles; results first posted 2021-10-29

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Cocaine Use Reduction With Buprenorphine. Trials, record NCT01402492. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT01402492

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Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Cocaine Use Reduction With Buprenorphine
NCT number: NCT01402492
Status: Completed
Phases: Phase 2, Phase 3
Enrollment: 302 participants, actual
Lead sponsor: University of California, Los Angeles
Conditions: Cocaine Dependence
Interventions: Buprenorphine + Naltrexone, Placebo + Naltrexone
First posted: 2011-07-26
Last updated: 2021-10-29
Results first posted: 2021-10-29

Source ClinicalTrials.gov

Registered outcomes1

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Cocaine Use Days as Measured by Self-report, Corroborated by Thrice-weekly Urine Drug Screens	final 30 days of Treatment Phase, study days 25-54	Self-reported days of cocaine use corroborated with urine drug screens (UDS).

Source ClinicalTrials.gov

Outcomes1

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Population	Units	Measured as
PRIMARY	Cocaine Use Days as Measured by Self-report, Corroborated by Thrice-weekly Urine Drug Screens	final 30 days of Treatment Phase, study days 25-54		days of cocaine use	MEAN

Source ClinicalTrials.gov

Results by group3

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Spread	Units
Cocaine Use Days as Measured by Self-report, Corroborated by Thrice-weekly Urine Drug Screens	BUP4+XR-NTX	6.6	Standard Deviation 5.25	days of cocaine use
Cocaine Use Days as Measured by Self-report, Corroborated by Thrice-weekly Urine Drug Screens	BUP16+XR-NTX	7.2	Standard Deviation 6.77	days of cocaine use
Cocaine Use Days as Measured by Self-report, Corroborated by Thrice-weekly Urine Drug Screens	PLB+XR-NTX	7.7	Standard Deviation 6.16	days of cocaine use

Source ClinicalTrials.gov

Participant flow9

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	BUP4+XR-NTX	100
Overall Study	STARTED	BUP16+XR-NTX	100
Overall Study	STARTED	PLB+XR-NTX	102
Overall Study	COMPLETED	BUP4+XR-NTX	79
Overall Study	COMPLETED	BUP16+XR-NTX	83
Overall Study	COMPLETED	PLB+XR-NTX	86
Overall Study	NOT COMPLETED	BUP4+XR-NTX	21
Overall Study	NOT COMPLETED	BUP16+XR-NTX	17
Overall Study	NOT COMPLETED	PLB+XR-NTX	16

Source ClinicalTrials.gov

Adverse events501

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk
other	Nausea	Gastrointestinal disorders	BUP4+XR-NTX	28	100
other	Nausea	Gastrointestinal disorders	BUP16+XR-NTX	32	100
other	Nausea	Gastrointestinal disorders	PLB+XR-NTX	21	102
other	Vomiting	Gastrointestinal disorders	BUP4+XR-NTX	12	100
other	Vomiting	Gastrointestinal disorders	BUP16+XR-NTX	15	100
other	Vomiting	Gastrointestinal disorders	PLB+XR-NTX	8	102
other	Constipation	Gastrointestinal disorders	BUP4+XR-NTX	10	100
other	Constipation	Gastrointestinal disorders	BUP16+XR-NTX	10	100
other	Constipation	Gastrointestinal disorders	PLB+XR-NTX	9	102
other	Diarrhea	Gastrointestinal disorders	BUP4+XR-NTX	3	100

1 to 10 of 501Source ClinicalTrials.gov

See all 501 adverse events

Adverse event totals9

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	BUP4+XR-NTX
Total, all-cause mortality	BUP16+XR-NTX
Total, all-cause mortality	PLB+XR-NTX
Total, other adverse events	BUP4+XR-NTX	66	100
Total, other adverse events	BUP16+XR-NTX	64	100
Total, other adverse events	PLB+XR-NTX	61	102
Total, serious adverse events	BUP4+XR-NTX	13	100
Total, serious adverse events	BUP16+XR-NTX	8	100
Total, serious adverse events	PLB+XR-NTX	12	102

Source ClinicalTrials.gov

Papers3

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as	Source
23159524	DERIVED	PubMed
26948856	RESULT	PubMed
42561565	DERIVED	PubMed

Grants1

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

Project	Title	Principal investigators	Organization	Funder	Fiscal years
U10DA013045	The National Drug Abuse Treatment Clinical Trials Network	LING, WALTER NMN	UNIVERSITY OF CALIFORNIA LOS ANGELES	NATIONAL INSTITUTE ON DRUG ABUSE	1999 to 2015

Source NIH RePORTER

Trial comparisons0

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

None in this release.

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT01402492

GET https://conductscience.org/api/trials/v1/NCT01402492/events?page=2

API reference For AI assistants