Trial · NCT01471522
International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA)
NCT01471522, Not applicable, Completed, NYU Langone Health; results first posted 2020-07-23
3 sourcestrials-2026-11-12-0.4.0
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ConductScience Library. International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA). Trials, record NCT01471522. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT01471522
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Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA)
- NCT number
- NCT01471522
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 5,179 participants, actual
- Lead sponsor
- NYU Langone Health
- Conditions
- Cardiovascular Diseases, Coronary Disease, Coronary Artery Disease, Heart Diseases, Myocardial Ischemia
- Interventions
- cardiac catheterization, coronary artery bypass graft surgery, percutaneous coronary intervention, Lifestyle, Medication
- First posted
- 2011-11-15
- Last updated
- 2023-06-01
- Results first posted
- 2020-07-23
Source ClinicalTrials.gov
Registered outcomes12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Primary Composite Outcome: Death From Cardiovascular Causes, Myocardial Infarction, or Hospitalization for Unstable Angina, Heart Failure, or Resuscitated Cardiac Arrest | 3.2 year follow-up (median) | |
| Primary | Cumulative Event Rate of Primary Composite Outcome (Death From Cardiovascular Causes, Myocardial Infarction, or Hospitalization for Unstable Angina, Heart Failure, or Resuscitated Cardiac Arrest) | 5 years | This measure represents the estimated cumulative probability of experiencing the primary endpoint within the indicated timeframe in each treatment group. The interpretation of the measure is similar to Kaplan-Meier event rates. Estimates are expressed as percentages ranging from 0% (endpoint is certain not to occur) to 100% (endpoint is certain to occur). |
| Primary | Number of Participants That Experienced Death From Cardiovascular Causes or Myocardial Infarction | 5 years | |
| Primary | Cumulative Event Rate of Death From Cardiovascular Causes or Myocardial Infarction | 5 years | This measure represents the estimated cumulative probability of experiencing Death from cardiovascular causes or myocardial infarction within the indicated timeframe in each treatment group. The interpretation of the measure is similar to Kaplan-Meier event rates. Estimates are expressed as percentages ranging from 0% (endpoint is certain not to occur) to 100% (endpoint is certain to occur). |
| Primary | Number of Participants That Experienced Death From Any Cause | 5 years | |
| Primary | Cumulative Event Rate of Death From Any Cause | 5 years | |
| Primary | Number of Participants That Experienced Myocardial Infarction | 5 years | |
| Primary | Cumulative Event Rate of Myocardial Infarction | 5 years | |
| Primary | Estimated Difference in Cumulative Event Rate ( %) of Primary Composite Outcome: Invasive Minus Conservative | 5 years | The primary composite outcome includes death from cardiovascular causes, myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. |
| Primary | Estimated Difference in Cumulative Event Rate of Death From Cardiovascular Causes: Invasive Minus Conservative or Myocardial Infarction Between Invasive and Conservative Strategies | 5 years |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 registered outcomesOutcomes12
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Primary Composite Outcome: Death From Cardiovascular Causes, Myocardial Infarction, or Hospitalization for Unstable Angina, Heart Failure, or Resuscitated Cardiac Arrest | 3.2 year follow-up (median) | Participants | COUNT_OF_PARTICIPANTS | |
| PRIMARY | Cumulative Event Rate of Primary Composite Outcome (Death From Cardiovascular Causes, Myocardial Infarction, or Hospitalization for Unstable Angina, Heart Failure, or Resuscitated Cardiac Arrest) | 5 years | cumulative event rate - % | NUMBER | |
| PRIMARY | Number of Participants That Experienced Death From Cardiovascular Causes or Myocardial Infarction | 5 years | Participants | COUNT_OF_PARTICIPANTS | |
| PRIMARY | Cumulative Event Rate of Death From Cardiovascular Causes or Myocardial Infarction | 5 years | Cumulative event rate -- % | NUMBER | |
| PRIMARY | Number of Participants That Experienced Death From Any Cause | 5 years | Participants | COUNT_OF_PARTICIPANTS | |
| PRIMARY | Cumulative Event Rate of Death From Any Cause | 5 years | Cumulative event rate -- % | NUMBER | |
| PRIMARY | Number of Participants That Experienced Myocardial Infarction | 5 years | Participants | COUNT_OF_PARTICIPANTS | |
| PRIMARY | Cumulative Event Rate of Myocardial Infarction | 5 years | Cumulative event rate -- % | NUMBER | |
| PRIMARY | Estimated Difference in Cumulative Event Rate ( %) of Primary Composite Outcome: Invasive Minus Conservative | 5 years | Invasive = 2588; Conservative = 2591 | cumulative event rate - % | NUMBER |
| PRIMARY | Estimated Difference in Cumulative Event Rate of Death From Cardiovascular Causes: Invasive Minus Conservative or Myocardial Infarction Between Invasive and Conservative Strategies | 5 years | Invasive = 2588; Conservative = 2591 | cumulative event rate - % | NUMBER |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 outcomesResults by group80
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Primary Composite Outcome: Death From Cardiovascular Causes, Myocardial Infarction, or Hospitalization for Unstable Angina, Heart Failure, or Resuscitated Cardiac Arrest | Invasive Strategy (INV) | 318 | Participants | ||
| Primary Composite Outcome: Death From Cardiovascular Causes, Myocardial Infarction, or Hospitalization for Unstable Angina, Heart Failure, or Resuscitated Cardiac Arrest | Conservative Strategy | 352 | Participants | ||
| Cumulative Event Rate of Primary Composite Outcome (Death From Cardiovascular Causes, Myocardial Infarction, or Hospitalization for Unstable Angina, Heart Failure, or Resuscitated Cardiac Arrest) | Invasive Strategy (INV) | At 6 months | 5.3 | cumulative event rate - % | |
| Cumulative Event Rate of Primary Composite Outcome (Death From Cardiovascular Causes, Myocardial Infarction, or Hospitalization for Unstable Angina, Heart Failure, or Resuscitated Cardiac Arrest) | Conservative Strategy | At 6 months | 3.4 | cumulative event rate - % | |
| Cumulative Event Rate of Primary Composite Outcome (Death From Cardiovascular Causes, Myocardial Infarction, or Hospitalization for Unstable Angina, Heart Failure, or Resuscitated Cardiac Arrest) | Invasive Strategy (INV) | At 1 year | 7.0 | cumulative event rate - % | |
| Cumulative Event Rate of Primary Composite Outcome (Death From Cardiovascular Causes, Myocardial Infarction, or Hospitalization for Unstable Angina, Heart Failure, or Resuscitated Cardiac Arrest) | Conservative Strategy | At 1 year | 5.4 | cumulative event rate - % | |
| Cumulative Event Rate of Primary Composite Outcome (Death From Cardiovascular Causes, Myocardial Infarction, or Hospitalization for Unstable Angina, Heart Failure, or Resuscitated Cardiac Arrest) | Invasive Strategy (INV) | At 2 years | 9.0 | cumulative event rate - % | |
| Cumulative Event Rate of Primary Composite Outcome (Death From Cardiovascular Causes, Myocardial Infarction, or Hospitalization for Unstable Angina, Heart Failure, or Resuscitated Cardiac Arrest) | Conservative Strategy | At 2 years | 9.5 | cumulative event rate - % | |
| Cumulative Event Rate of Primary Composite Outcome (Death From Cardiovascular Causes, Myocardial Infarction, or Hospitalization for Unstable Angina, Heart Failure, or Resuscitated Cardiac Arrest) | Invasive Strategy (INV) | At 3 years | 11.3 | cumulative event rate - % | |
| Cumulative Event Rate of Primary Composite Outcome (Death From Cardiovascular Causes, Myocardial Infarction, or Hospitalization for Unstable Angina, Heart Failure, or Resuscitated Cardiac Arrest) | Conservative Strategy | At 3 years | 12.7 | cumulative event rate - % |
1 to 10 of 80Source ClinicalTrials.gov
See all 80 results by groupParticipant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Invasive Strategy (INV) | 2,588 | |
| Overall Study | STARTED | Conservative Strategy | 2,591 | |
| Overall Study | COMPLETED | Invasive Strategy (INV) | 2,524 | |
| Overall Study | COMPLETED | Conservative Strategy | 2,543 | |
| Overall Study | NOT COMPLETED | Invasive Strategy (INV) | 64 | |
| Overall Study | NOT COMPLETED | Conservative Strategy | 48 |
Source ClinicalTrials.gov
Adverse events14
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| serious | Cardiovascular Death | Cardiac disorders | Invasive Strategy (INV) | 92 | 2,588 | 92 |
| serious | Cardiovascular Death | Cardiac disorders | Conservative Strategy | 111 | 2,591 | 111 |
| serious | Procedural Myocardial Infarction | Cardiac disorders | Invasive Strategy (INV) | 70 | 2,588 | 70 |
| serious | Procedural Myocardial Infarction | Cardiac disorders | Conservative Strategy | 24 | 2,591 | 24 |
| serious | Non-procedural Myocardial Infarction | Cardiac disorders | Invasive Strategy (INV) | 130 | 2,588 | 130 |
| serious | Non-procedural Myocardial Infarction | Cardiac disorders | Conservative Strategy | 196 | 2,591 | 196 |
| serious | Hospitalization for Unstable Angina | Cardiac disorders | Invasive Strategy (INV) | 16 | 2,588 | 16 |
| serious | Hospitalization for Unstable Angina | Cardiac disorders | Conservative Strategy | 32 | 2,591 | 32 |
| serious | Hospitalization for Heart Failure | Cardiac disorders | Invasive Strategy (INV) | 51 | 2,588 | 51 |
| serious | Hospitalization for Heart Failure | Cardiac disorders | Conservative Strategy | 25 | 2,591 | 25 |
1 to 10 of 14Source ClinicalTrials.gov
See all 14 adverse eventsAdverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Invasive Strategy (INV) | 145 | 2,588 |
| Total, all-cause mortality | Conservative Strategy | 144 | 2,591 |
| Total, other adverse events | Invasive Strategy (INV) | 0 | 2,588 |
| Total, other adverse events | Conservative Strategy | 0 | 2,591 |
| Total, serious adverse events | Invasive Strategy (INV) | 318 | 2,588 |
| Total, serious adverse events | Conservative Strategy | 352 | 2,591 |
Source ClinicalTrials.gov
Papers53
The papers the trial lists on ClinicalTrials.gov.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| U01HL105907 | The Ischemia Trial - CCC | HOCHMAN, JUDITH S | NEW YORK UNIVERSITY SCHOOL OF MEDICINE | NATIONAL HEART, LUNG, AND BLOOD INSTITUTE | 2011 to 2019 |
Source NIH RePORTER
Trial comparisons6
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Invasive Strategy (INV) vs Conservative Strategy: Number of Participants That Experienced Death From Any Cause | Trial comparisons |
| Invasive Strategy (INV) vs Conservative Strategy: Number of Participants That Experienced Death From Cardiovascular Causes or Myocardial Infarction | Trial comparisons |
| Invasive Strategy (INV) vs Conservative Strategy: Number of Participants That Experienced Myocardial Infarction | Trial comparisons |
Invasive Strategy (INV) vs Conservative Strategy: Primary Composite Outcome: Death From Cardiovascular Causes, Myocardial Infarction, or Hospitalization for Unstable Angina, Heart Failure, or Resuscitated Cardiac Arrest | Trial comparisons |
| Invasive Strategy (INV) vs Conservative Strategy: deaths from any cause | Trial comparisons |
| Invasive Strategy (INV) vs Conservative Strategy: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Source
- Release
- trials-2026-11-12-0.4.0
- Release manifest SHA-256
- 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4
- Registry capture
- 2026-11-12
- Results copy, AACT
- 2026-03-23
- NIH clinical studies file
- 2026-11-13
Source ClinicalTrials.gov
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT01471522
GET https://conductscience.org/api/trials/v1/NCT01471522/results?page=2