Trial · NCT01472874
Single Daily Dosage of Trientine for Maintenance Treatment for Wilson Disease
NCT01472874, Not applicable, Completed, Yale University; results first posted 2014-05-19
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Single Daily Dosage of Trientine for Maintenance Treatment for Wilson Disease. Trials, record NCT01472874. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT01472874
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Single Daily Dosage of Trientine for Maintenance Treatment for Wilson Disease
- NCT number
- NCT01472874
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 8 participants, actual
- Lead sponsor
- Yale University
- Conditions
- Wilson Disease
- Interventions
- Once a day Trientine
- First posted
- 2011-11-17
- Last updated
- 2020-04-15
- Results first posted
- 2014-05-19
Source ClinicalTrials.gov
Registered outcomes12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | ALT | Pre Treatment (mean) | Alanine transaminase |
| Primary | ALT | Months 1,2,3,6,9,12 (mean) | Alanine transaminase |
| Primary | Cu Serum | Pre Treatment (mean) | |
| Primary | Cu Serum | Months 1,2,3,6,9,12 (mean) | |
| Secondary | INR | Pre Treatment (mean) | The International Normalized Ratio (INR) is a standard way to describe the time it takes for blood to clot; an INR range of 0.8 to 1.2 is considered normal for a healthy person who is not using oral anticoagulant therapy |
| Secondary | INR | Months 1,2,3,6,9,12 (mean) | The International Normalized Ratio (INR) is a standard way to describe the time it takes for blood to clot; an INR range of 0.8 to 1.2 is considered normal for a healthy person who is not using oral anticoagulant therapy |
| Secondary | Albumin | Pre Treatment (mean) | |
| Secondary | Albumin | Months 1,2,3,6,9,12 (mean) | |
| Secondary | Cu Urine | Pre Treatment (mean) | |
| Secondary | Cu Urine | Months 1,2,3,6,9,12 (mean) |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 registered outcomesOutcomes12
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | ALT | Pre Treatment (mean) | U/L | MEAN | |
| PRIMARY | ALT | Months 1,2,3,6,9,12 (mean) | U/L | MEAN | |
| SECONDARY | INR | Pre Treatment (mean) | international normalized ratio | MEAN | |
| SECONDARY | INR | Months 1,2,3,6,9,12 (mean) | international normalized ratio | MEAN | |
| SECONDARY | Albumin | Pre Treatment (mean) | g/dL | MEAN | |
| SECONDARY | Albumin | Months 1,2,3,6,9,12 (mean) | g/dL | MEAN | |
| PRIMARY | Cu Serum | Pre Treatment (mean) | mcg/24h | MEAN | |
| PRIMARY | Cu Serum | Months 1,2,3,6,9,12 (mean) | mcg/24h | MEAN | |
| SECONDARY | Cu Urine | Pre Treatment (mean) | mcg/24hr | MEAN | |
| SECONDARY | Cu Urine | Months 1,2,3,6,9,12 (mean) | mcg/24hr | MEAN |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 outcomesResults by group12
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| ALT | Once a Day Trientine | 41.38 | Standard Deviation 31.81 | U/L | |
| ALT | Once a Day Trientine | 50.89 | Standard Deviation 32.29 | U/L | |
| INR | Once a Day Trientine | 0.99 | Standard Deviation 0.07 | international normalized ratio | |
| INR | Once a Day Trientine | 1.05 | Standard Deviation 0.08 | international normalized ratio | |
| Albumin | Once a Day Trientine | 0.54 | Standard Deviation 0.30 | g/dL | |
| Albumin | Once a Day Trientine | 0.52 | Standard Deviation 0.30 | g/dL | |
| Cu Serum | Once a Day Trientine | 0.54 | Standard Deviation 0.30 | mcg/24h | |
| Cu Serum | Once a Day Trientine | 0.52 | Standard Deviation 0.30 | mcg/24h | |
| Cu Urine | Once a Day Trientine | 287.9 | Standard Deviation 259.1 | mcg/24hr | |
| Cu Urine | Once a Day Trientine | 313.4 | Standard Deviation 191.7 | mcg/24hr |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 results by groupParticipant flow3
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Once a Day Trientine | 8 | |
| Overall Study | COMPLETED | Once a Day Trientine | 8 | |
| Overall Study | NOT COMPLETED | Once a Day Trientine | 0 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals3
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Once a Day Trientine | ||
| Total, other adverse events | Once a Day Trientine | 0 | 8 |
| Total, serious adverse events | Once a Day Trientine | 0 | 8 |
Source ClinicalTrials.gov
Papers11
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT01472874
GET https://conductscience.org/api/trials/v1/NCT01472874/registered