Trial · NCT01500473
Therapeutic Effect of Desogestrel on Ventilatory Control in Patients With Congenital Central Hypoventilation Syndrome
NCT01500473, Phase 2, Terminated, Children's Hospital Los Angeles; results first posted 2023-09-28
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Therapeutic Effect of Desogestrel on Ventilatory Control in Patients With Congenital Central Hypoventilation Syndrome. Trials, record NCT01500473. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT01500473
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Therapeutic Effect of Desogestrel on Ventilatory Control in Patients With Congenital Central Hypoventilation Syndrome
- NCT number
- NCT01500473
- Status
- Terminated
- Phases
- Phase 2
- Enrollment
- 1 participants, actual
- Lead sponsor
- Children's Hospital Los Angeles
- Conditions
- Congenital Central Hypoventilation Syndrome
- Interventions
- Desogestrel
- First posted
- 2011-12-28
- Last updated
- 2023-11-18
- Results first posted
- 2023-09-28
- Limitations and caveats
- Early termination leading to small numbers of subjects analyzed. Only one subject was enrolled.
Source ClinicalTrials.gov
Registered outcomes3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Hypoxic Ventilatory Response | 3 weeks | Increase in minute ventilation as oxygen saturation of hemoglobin falls. |
| Primary | Hypercapnic Ventilatory Response | 3 weeks | Increase in ventilation with increasing partial pressure of CO2 |
| Primary | Time Maintained Ventilation Off Mechanical Ventilation During Sleep. | 3 weeks | length of time the subject could breathe adequately spontaneously until SpO2 fell below 80% and or PetCO2 rose above 65 mmHg. |
Source ClinicalTrials.gov
Outcomes3
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Hypoxic Ventilatory Response | 3 weeks | subjects with positive response | NUMBER | |
| PRIMARY | Hypercapnic Ventilatory Response | 3 weeks | liters per minute/ mmHg PCO2 | NUMBER | |
| PRIMARY | Time Maintained Ventilation Off Mechanical Ventilation During Sleep. | 3 weeks | seconds | NUMBER |
Source ClinicalTrials.gov
Results by group3
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Hypoxic Ventilatory Response | Females With CCHS > 16 Years Old on Desogetrel | 0 | subjects with positive response | ||
| Hypercapnic Ventilatory Response | Females With CCHS > 16 Years Old on Desogestrel | -0.520 | liters per minute/ mmHg PCO2 | ||
| Time Maintained Ventilation Off Mechanical Ventilation During Sleep. | Females With CCHS > 16 Years Old on Desogestrel | 89 | seconds |
Source ClinicalTrials.gov
Participant flow3
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Females With CCHS > 16 Years Old on Desogetrel | 1 | |
| Overall Study | COMPLETED | Females With CCHS > 16 Years Old on Desogetrel | 1 | |
| Overall Study | NOT COMPLETED | Females With CCHS > 16 Years Old on Desogetrel | 0 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals3
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Females With CCHS > 16 Years Old on Desogetrel | 0 | 1 |
| Total, other adverse events | Females With CCHS > 16 Years Old on Desogetrel | 0 | 1 |
| Total, serious adverse events | Females With CCHS > 16 Years Old on Desogetrel | 0 | 1 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT01500473
GET https://conductscience.org/api/trials/v1/NCT01500473/registered