Effect of Sarcosine on Symptomatology, Quality of Life, Oxidative Stress and Glutamatergic Parameters in Schizophrenia
NCT01503359, Phase 2, Completed, Medical University of Lodz
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Effect of Sarcosine on Symptomatology, Quality of Life, Oxidative Stress and Glutamatergic Parameters in Schizophrenia | ClinicalTrials.gov |
| NCT number | NCT01503359 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Phase 2 | ClinicalTrials.gov |
| Enrollment | 70 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Medical University of Lodz | ClinicalTrials.gov |
| Conditions | Schizophrenia | ClinicalTrials.gov |
| Interventions | Sarcosine | ClinicalTrials.gov |
| First posted | 2012-01-04 | ClinicalTrials.gov |
| Last updated | 2016-09-16 | ClinicalTrials.gov |
Registered outcomes 8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Assessment of sarcosine vs. placebo impact on schizophrenia symptoms using Positive and Negative Syndrome Scale (PANSS). | 6 months | Both arms, every visit | ClinicalTrials.gov |
| Secondary | Impact assessment of sarcosine versus placebo on the parameters of quality of life (QoL) and sexual functioning. | 6 months | Both arms, every visit | ClinicalTrials.gov |
| Secondary | Impact assessment of sarcosine versus placebo on depressive symptoms using Calgary Depression Scale for Schizophrenia. | 6 months | Both arms, every visit | ClinicalTrials.gov |
| Secondary | Impact assessment of sarcosine versus placebo on cognitive functions using Wisconsin Card Sort Test, Trail Making Test and Stroop Test. | 6 months | Both arms, before and after taking sarcosine or placebo | ClinicalTrials.gov |
| Secondary | Impact assessment of sarcosine versus placebo on oxidative stress parameters (T-BARS). | 6 months | Both arms, before and after taking sarcosine or placebo | ClinicalTrials.gov |
| Secondary | Impact assessment of sarcosine versus placebo on brain metabolism parameters (magnetic resonance spectroscopy). | 6 months | Both arms, before and after taking sarcosine or placebo | ClinicalTrials.gov |
| Secondary | Impact assessment of sarcosine versus placebo on oculomotoric parameters (saccadic and antisaccadic task in electrooculography). | 6 months | Both arms, before and after taking sarcosine or placebo | ClinicalTrials.gov |
| Secondary | Impact assessment of sarcosine versus placebo on blood levels of glycine, sarcosine, BDNF and MMP-9. | 6 months | Both arms, before and after taking sarcosine or placebo | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 22
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|---|---|
| 1654746 | BACKGROUND | PubMed |
| 1695402 | BACKGROUND | PubMed |
| 7751957 | BACKGROUND | PubMed |
| 8036251 | BACKGROUND | PubMed |
| 9384954 | BACKGROUND | PubMed |
| 9798069 | BACKGROUND | PubMed |
| 10628529 | BACKGROUND | PubMed |
| 10719161 | BACKGROUND | PubMed |
| 10873924 | BACKGROUND | PubMed |
| 11532718 | BACKGROUND | PubMed |
| 11588613 | BACKGROUND | PubMed |
| 11806864 | BACKGROUND | PubMed |
| 14684435 | BACKGROUND | PubMed |
| 15023571 | BACKGROUND | PubMed |
| 15502972 | BACKGROUND | PubMed |
| 15708298 | BACKGROUND | PubMed |
| 16625590 | BACKGROUND | PubMed |
| 16780811 | BACKGROUND | PubMed |
| 17659263 | BACKGROUND | PubMed |
| 26306650 | DERIVED | PubMed |
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 3
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Trail Making Test A | Secondary outcome | ConductCognition |
| Trail Making Test B | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)