Trial · NCT01514357
Nesiritide in Resistant Hypertension
NCT01514357, Phase 1, Phase 2, Terminated, John C Burnett; results first posted 2017-10-20
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Nesiritide in Resistant Hypertension. Trials, record NCT01514357. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT01514357
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Nesiritide in Resistant Hypertension
- NCT number
- NCT01514357
- Status
- Terminated
- Phases
- Phase 1, Phase 2
- Enrollment
- 12 participants, actual
- Lead sponsor
- John C Burnett
- Conditions
- Hypertension
- Interventions
- Nesiritide (BNP), Placebo
- First posted
- 2012-01-23
- Last updated
- 2018-03-23
- Results first posted
- 2017-10-20
- Limitations and caveats
- This study was terminated early because the original principal investigator left the institution, and also due to the lack of funding.
Source ClinicalTrials.gov
Registered outcomes1
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Changes in Systolic Blood Pressure (BP) | baseline, treatment day 1, treatment day 2 | The change in BP with treatment over 7 days was assessed by the mean BP on admission, (treatment day 1) mean BP 23 hours after the first injection of BNP, and mean BP 23 hours after the second injection of BNP (treatment day 2). Treatment day 2 was 7 days after admission. |
Source ClinicalTrials.gov
Outcomes1
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Changes in Systolic Blood Pressure (BP) | baseline, treatment day 1, treatment day 2 | mmHg | MEAN |
Source ClinicalTrials.gov
Results by group3
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Changes in Systolic Blood Pressure (BP) | Nesiritide (BNP) | Baseline | 153 | Standard Deviation 9.180 | mmHg |
| Changes in Systolic Blood Pressure (BP) | Nesiritide (BNP) | Treatment Day 1 | 134 | Standard Deviation 9.07 | mmHg |
| Changes in Systolic Blood Pressure (BP) | Nesiritide (BNP) | Treatment Day 2 | 129 | Standard Deviation 17.34 | mmHg |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Nesiritide (BNP) | 12 | |
| Overall Study | STARTED | Placebo | 0 | |
| Overall Study | COMPLETED | Nesiritide (BNP) | 8 | |
| Overall Study | COMPLETED | Placebo | 0 | |
| Overall Study | NOT COMPLETED | Nesiritide (BNP) | 4 | |
| Overall Study | NOT COMPLETED | Placebo | 0 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Nesiritide (BNP) | 0 | 8 |
| Total, all-cause mortality | Placebo | 0 | 0 |
| Total, other adverse events | Nesiritide (BNP) | 0 | 8 |
| Total, other adverse events | Placebo | 0 | 0 |
| Total, serious adverse events | Nesiritide (BNP) | 0 | 8 |
| Total, serious adverse events | Placebo | 0 | 0 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| UL1RR024150 | Mayo Clinic Center for Translational Science Activities | RIZZA, ROBERT A. | MAYO CLINIC ROCHESTER | NATIONAL CENTER FOR RESEARCH RESOURCES | 2006 to 2011 |
Source NIH RePORTER
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT01514357
GET https://conductscience.org/api/trials/v1/NCT01514357/registered