ENLIGHTEN: Exercise and NutritionaL Interventions for coGnitive and Cardiovascular HealTh ENhancement
NCT01573546, Not applicable, Completed, Duke University
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | ENLIGHTEN: Exercise and NutritionaL Interventions for coGnitive and Cardiovascular HealTh ENhancement | ClinicalTrials.gov |
| NCT number | NCT01573546 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 160 participants, actual | ClinicalTrials.gov |
| Lead sponsor | Duke University | ClinicalTrials.gov |
| Conditions | Cognitive Impairment, no Dementia (CIND) | ClinicalTrials.gov |
| Interventions | Aerobic Exercise, DASH diet, Health education control | ClinicalTrials.gov |
| First posted | 2012-04-09 | ClinicalTrials.gov |
| Last updated | 2018-04-18 | ClinicalTrials.gov |
Registered outcomes 11
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Change in Executive Function | Baseline to post-treatment assessment at 6 months | Composite executive function measure includes Trail Making Test, Stroop Test, Digit Span, Digit Symbol Substitution Test, Ruff 2 \& 7 Test, and Animal Naming Test | ClinicalTrials.gov |
| Secondary | Change in Memory | 6 months | Secondary outcomes will include composite measures of memory (Hopkins Verbal Learning Test-Revised and Medical College of Georgia Complex Figure Test) | ClinicalTrials.gov |
| Secondary | Change in Language | 6 months | Secondary outcomes will include composite measures of language (Controlled Oral Word Association Test and Animal Naming Test) | ClinicalTrials.gov |
| Secondary | Inflammation | 6 months | We will also assess treatment effects on measures of inflammation, including C-reactive protein and interleukin-6. | ClinicalTrials.gov |
| Secondary | Functional Capacity | 6 months | Functional capacity (6MWT and peak VO2). Six-minute walk distance (6MWT) and peak VO2 from a treadmill test will be assessed by an exercise physiologist. | ClinicalTrials.gov |
| Secondary | Blood Pressure | 6 months | We also will examine treatment effects on the vascular function measures, including blood pressure. | ClinicalTrials.gov |
| Secondary | Flow-mediated dilation of the brachial artery | 6 months | We also will examine treatment effects on the vascular function measures, including flow-mediated dilation of the brachial artery. | ClinicalTrials.gov |
| Secondary | Arterial Stiffness | 6 months | We also will examine treatment effects on the vascular function measures, including pulse-wave velocity of the femoral artery. | ClinicalTrials.gov |
| Secondary | Intima-medial thickness | 6 months | We also will examine treatment effects on the vascular function measures, including intima-medial thickness of the carotid artery. | ClinicalTrials.gov |
| Secondary | Fasting glucose | 6 months | We will also assess treatment effects on measures fasting glucose | ClinicalTrials.gov |
| Secondary | Cholesterol | 6 months | We will also examine treatment effects on cholesterol, including LDL, HDL, and total cholesterol | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 4
The papers the trial lists on ClinicalTrials.gov.
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 9
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Category Fluency | Primary outcome | ConductCognition |
| Digit Span Test | Primary outcome | ConductCognition |
| Stroop Color-Word Test | Primary outcome | ConductCognition |
| Symbol Coding | Primary outcome | ConductCognition |
| Trail Making Test A | Primary outcome | ConductCognition |
| Trail Making Test B | Primary outcome | ConductCognition |
| Complex Figure Copy and Recall | Secondary outcome | ConductCognition |
| Verbal Fluency | Secondary outcome | ConductCognition |
| Verbal Learning | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)