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Trial · NCT01637623

Registered outcomes11

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

ListOutcomeTime frameDescription
PrimaryChange in Muscle Sympathetic Nerve Activity Responses During Hypoxiabaseline and 6 weeksThe primary outcome variable is the change in the individual slope of the MSNA - SaO2 response curve at 6 weeks and baseline between treatment groups.
SecondaryChange in Aortic Pulse Wave Velocitybaseline and 6 weeksmeasurement of vascular stiffness assessed before and after study drug treatment
SecondaryCerebrovascular Conductancebaseline and 6 weeks
Assessment measures of cerebral blood flow during basal conditions and during graded hypoxia before and after study drug treatment. Cerebrovascular conductance (CVC) was calculated as velocity-time integral/mean arterial pressure.
SecondaryForearm Vascular Conductancebaseline and 6 weeksAssessment measurements of forearm vascular conductance during basal conditions and during graded hypoxia before and after study drug treatment.
SecondaryChange in Minute Ventilation at Normoxiabaseline and 6 weeksassessed before and after study drug treatment
SecondaryChange in Minute Ventilation During Hypoxiabaseline and 6 weeksassessed before and after study drug treatment
SecondaryAortic Augmentation Indexbaseline and 6 weeksassessed before and after study drug treatment
SecondaryMean Change in PERCENT Vasodilationbaseline and 6 weeksFlow-mediated vasodilation (FMD) (measurement of vascular endothelial function) assessed before and after study drug treatment
SecondaryApnea-Hypopnea Indexbaseline and 6 weeksSeverity of sleep apnea assessed before and after study drug treatment
SecondaryPERCENT Time Spent Below 88 PERCENT Oxygen Saturationbaseline and 6 weeksassessed before and after study drug treatment
SecondaryChange in Mean 24-Hour Blood Pressure (Mean Arterial Pressure)baseline and 6 weeksChange in mean 24 hour blood pressure (mean arterial pressure)

Source ClinicalTrials.govtrials-2026-11-12-0.4.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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