Trial · NCT01640171
Anesthesia Preference for Intravitreal Injection: Topical or Subconjunctival
NCT01640171, Not applicable, Completed, Retina Vitreous Associates of Florida; results first posted 2014-04-21
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Anesthesia Preference for Intravitreal Injection: Topical or Subconjunctival. Trials, record NCT01640171. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT01640171
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Anesthesia Preference for Intravitreal Injection: Topical or Subconjunctival
- NCT number
- NCT01640171
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 57 participants, actual
- Lead sponsor
- Retina Vitreous Associates of Florida
- Conditions
- Age-related Macular Degeneration, Central Retinal Vein Occlusion, Diabetic Macular Edema
- Interventions
- Xylocaine 2% Injectable Anesthetic, Proparacaine Hydrochloride 0.5% Drop, Tetravisc 0.5% Gel, Acuvail, Intra-vitreal Anti-VEGF Drug
- First posted
- 2012-07-13
- Last updated
- 2014-04-21
- Results first posted
- 2014-04-21
- Limitations and caveats
- Most patients were treated with subconjunctival anesthetic prior to the study.
Source ClinicalTrials.gov
Registered outcomes3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Number of Participants Who Preferred Subconjunctival Anesthetic at the Third Follow-up Visit | up to 6 months | Participants received anesthetic over several treatment visits. They were allowed to change there preference at each visit. The final outcome was the preference indicated at the third follow-up visit. |
| Secondary | Number of Participatns With Level 10 Pain on Wong-Baker Pain Scale In Subconjunctival Eye At Time of Intravitreal Injection | 24 hours | Pain was rated on a 10 point standardized pain scale, zero was the least pain and 10 was the worst pain. The patient was questioned using a script and shown a pain scale as well as told how the pain scale worked. Then the patient gave the number that characterized their pain. |
| Secondary | Likert Like Pain Scale Number of Participants Who Said the Topical Eye Hurt Much More Than the Subconjunctival Eye at Time of Intravitreal Injection | 24 hours | The patient was asked to compare the two eyes in the way described in the study protocol on a five point scale. If one eye hurt a lot more or a little more than the other or if the two eyes were equal (neither hurt more than the other). |
Source ClinicalTrials.gov
Outcomes3
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Number of Participants Who Preferred Subconjunctival Anesthetic at the Third Follow-up Visit | up to 6 months | participants | NUMBER | |
| SECONDARY | Number of Participatns With Level 10 Pain on Wong-Baker Pain Scale In Subconjunctival Eye At Time of Intravitreal Injection | 24 hours | All patients in the study | participants | NUMBER |
| SECONDARY | Likert Like Pain Scale Number of Participants Who Said the Topical Eye Hurt Much More Than the Subconjunctival Eye at Time of Intravitreal Injection | 24 hours | total group | participants | NUMBER |
Source ClinicalTrials.gov
Results by group3
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Number of Participants Who Preferred Subconjunctival Anesthetic at the Third Follow-up Visit | Topical Anesthesia 1 Eye, SC 1 Eye | 50 | participants | ||
| Number of Participatns With Level 10 Pain on Wong-Baker Pain Scale In Subconjunctival Eye At Time of Intravitreal Injection | Topical Anesthesia 1 Eye, SC 1 Eye | 0 | participants | ||
| Likert Like Pain Scale Number of Participants Who Said the Topical Eye Hurt Much More Than the Subconjunctival Eye at Time of Intravitreal Injection | Topical Anesthesia 1 Eye, SC 1 Eye | 19 | participants |
Source ClinicalTrials.gov
Participant flow3
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Topical Anesthesia 1 Eye, SC 1 Eye | 57 | |
| Overall Study | COMPLETED | Topical Anesthesia 1 Eye, SC 1 Eye | 57 | |
| Overall Study | NOT COMPLETED | Topical Anesthesia 1 Eye, SC 1 Eye | 0 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Topical Anesthesia | ||
| Total, all-cause mortality | Subconjunctival Anesthesia | ||
| Total, other adverse events | Topical Anesthesia | 0 | 57 |
| Total, other adverse events | Subconjunctival Anesthesia | 0 | 57 |
| Total, serious adverse events | Topical Anesthesia | 0 | 57 |
| Total, serious adverse events | Subconjunctival Anesthesia | 0 | 57 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons1
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison |
|---|
| Topical Anesthesia vs Subconjunctival Anesthesia: serious adverse events |
Source Trial comparisons
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT01640171
GET https://conductscience.org/api/trials/v1/NCT01640171/registered