Trial · NCT01727167
CO as a Stimulant for Mitochondrial Biogenesis in Human Cardiac Muscle
NCT01727167, Phase 1, Phase 2, Terminated, John J Freiberger; results first posted 2016-05-19
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. CO as a Stimulant for Mitochondrial Biogenesis in Human Cardiac Muscle. Trials, record NCT01727167. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT01727167
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- CO as a Stimulant for Mitochondrial Biogenesis in Human Cardiac Muscle
- NCT number
- NCT01727167
- Status
- Terminated
- Phases
- Phase 1, Phase 2
- Enrollment
- 1 participants, actual
- Lead sponsor
- John J Freiberger
- Conditions
- Cardiac Disease, Mitochondrial Biogenesis, Carbon Monoxide
- Interventions
- 200ppm CO for one hour, Control
- First posted
- 2012-11-15
- Last updated
- 2016-05-19
- Results first posted
- 2016-05-19
- Limitations and caveats
- Terminated study due to low accrual.
Source ClinicalTrials.gov
Registered outcomes2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Biochemical Markers for Mitochondrial Biogenesis (Blood and Right Atrial Tissue) | 2 weeks | Right atrial biochemical markers will be measured one time only, intra-operatively. Blood Biochemical markers will be measured before CO exposure and at intervals up to one week post-operatively |
| Secondary | Compare Blood to Right Atrial Tissue Biochemical Markers of Mitochondrial Biogenesis | on week | Biochemical markers in both right atrial tissue and blood will be measured and compared to see if the more easily obtained blood markers accurately describe changes expected in the heart. |
Source ClinicalTrials.gov
Outcomes2
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Biochemical Markers for Mitochondrial Biogenesis (Blood and Right Atrial Tissue) | 2 weeks | Molecular data was not collected for the single enrolled participant. | ||
| SECONDARY | Compare Blood to Right Atrial Tissue Biochemical Markers of Mitochondrial Biogenesis | on week | Molecular data was not collected for the single enrolled participant. |
Source ClinicalTrials.gov
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Control Group | 1 | |
| Overall Study | STARTED | CO Group | 0 | |
| Overall Study | COMPLETED | Control Group | 1 | |
| Overall Study | COMPLETED | CO Group | 0 | |
| Overall Study | NOT COMPLETED | Control Group | 0 | |
| Overall Study | NOT COMPLETED | CO Group | 0 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Control Group | ||
| Total, all-cause mortality | CO Group | ||
| Total, other adverse events | Control Group | 0 | 1 |
| Total, other adverse events | CO Group | 0 | 0 |
| Total, serious adverse events | Control Group | 0 | 1 |
| Total, serious adverse events | CO Group | 0 | 0 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT01727167
GET https://conductscience.org/api/trials/v1/NCT01727167/registered