Trial · NCT01747174
REperfusion Facilitated by LOcal Adjunctive Therapy in ST-elevation Myocardial Infarction
NCT01747174, Phase 2, Completed, University Hospitals, Leicester
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. REperfusion Facilitated by LOcal Adjunctive Therapy in ST-elevation Myocardial Infarction. Trials, record NCT01747174. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT01747174
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- REperfusion Facilitated by LOcal Adjunctive Therapy in ST-elevation Myocardial Infarction
- NCT number
- NCT01747174
- Status
- Completed
- Phases
- Phase 2
- Enrollment
- 247 participants, actual
- Lead sponsor
- University Hospitals, Leicester
- Conditions
- ST-elevation Myocardial Infarction (STEMI)
- Interventions
- IC Adenosine, IC Sodium nitroprusside (SNP), Standard PCI
- First posted
- 2012-12-11
- Last updated
- 2015-06-16
- Other registries' IDs
- eudract:2010-023211-34
Source ClinicalTrials.gov
Registered outcomes10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | CMR measured infarct size (% LV mass) | 48-72 hours post procedure | |
| Secondary | CMR incidence and extent of MVO (% LV mass) | 48-72 hours post procedure | |
| Secondary | CMR measured myocardial salvage index, haemorrhage, LV EF and volumes | 48-72 hours post procedure | |
| Secondary | Myocardial Blush Grade assessed by validated computer software 'Quantitative Blush Evaluator' (QuBE | During P-PCI | |
| Secondary | Incidence pre- and post- procedure angiographic true "no-reflow" | During P-PCI | |
| Secondary | Any in-patient clinical events | Within 6 months from presentation with, and PCI for, STEMI | Includes: coronary artery re-occlusion, need for repeat PCI, recurrent chest pain with new ECG changes, incidence of clinical heart failure (symptoms plus basal crackles plus X-ray evidence of pulmonary congestion) and proven cerebrovascular accident (CVA). |
| Secondary | Overall MACE | 1 month | MACE: composite of death, need for target lesion revascularization, recurrent MI, severe heart failure, and CVA. |
| Secondary | Degree of ST segment resolution on ECG | Assessed immediately following P-PCI (expected on average 1 hour) | |
| Secondary | Echocardiographic assessment of LV | 6-8 weeks post-procedure/MI | To include end systolic/diastolic volumes, EF +/- wall motion index |
| Secondary | Corrected TIMI Frame Count | During procedure | TIMI frame count or TFC is defined as the number of cineframes required for contrast to reach a standardized distal coronary landmark in the culprit vessel. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT01747174
GET https://conductscience.org/api/trials/v1/NCT01747174/registered