Trial · NCT01780337
Oxytocin Effects on Cardiac Electrophysiology
NCT01780337, Early phase 1, Completed, William Whang; results first posted 2016-06-17
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Oxytocin Effects on Cardiac Electrophysiology. Trials, record NCT01780337. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT01780337
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Oxytocin Effects on Cardiac Electrophysiology
- NCT number
- NCT01780337
- Status
- Completed
- Phases
- Early phase 1
- Enrollment
- 12 participants, actual
- Lead sponsor
- William Whang
- Conditions
- Cardiac Arrhythmia
- Interventions
- Oxytocin, Saline
- First posted
- 2013-01-31
- Last updated
- 2016-07-21
- Results first posted
- 2016-06-17
Source ClinicalTrials.gov
Registered outcomes3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in Electrophysiology Measure of AH Interval | Baseline and 30 min | First measured at time zero, then at 30 minutes after administration of the study medication/placebo. During the waiting periods in between the electrophysiologic measurements, the investigators will continue with the standard protocol for an AF ablation, including transseptal puncture and left atrial mapping, performed prior to initiation of general anesthesia and actual delivery of ablation lesions. This 'pre- ablation' period normally takes 45 minutes to one hour. |
| Primary | Change in Electrophysiology Measure of HV Interval | Baseline and 30 min | First measured at time zero, then at 30 minutes after administration of the study medication/placebo. During the waiting periods in between the electrophysiologic measurements, the investigators will continue with the standard protocol for an AF ablation, including transseptal puncture and left atrial mapping, performed prior to initiation of general anesthesia and actual delivery of ablation lesions. This 'pre- ablation' period normally takes 45 minutes to one hour. |
| Primary | Change in Electrophysiology Measure of Right Ventricular Refractory Period | Baseline and 30 min | First measured at time zero, then at 30 minutes after administration of the study medication/placebo. During the waiting periods in between the electrophysiologic measurements, the investigators will continue with the standard protocol for an AF ablation, including transseptal puncture and left atrial mapping, performed prior to initiation of general anesthesia and actual delivery of ablation lesions. This 'pre- ablation' period normally takes 45 minutes to one hour. |
Source ClinicalTrials.gov
Outcomes3
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Change in Electrophysiology Measure of AH Interval | Baseline and 30 min | Only 3 out of 6 were evaluable for the Oxytocin group. Only 2 out of 6 were evaluable for the Saline group. | milliseconds | MEAN |
| PRIMARY | Change in Electrophysiology Measure of HV Interval | Baseline and 30 min | Only 4 out of 6 were evaluable for the Oxytocin group. Only 5 out of 6 were evaluable for the Saline group. | milliseconds | MEAN |
| PRIMARY | Change in Electrophysiology Measure of Right Ventricular Refractory Period | Baseline and 30 min | Only 4 out of 6 were evaluable for the Oxytocin group. | milliseconds | MEAN |
Source ClinicalTrials.gov
Results by group6
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Change in Electrophysiology Measure of AH Interval | Oxytocin | 12.7 | Standard Deviation 11.2 | milliseconds | |
| Change in Electrophysiology Measure of AH Interval | Saline | -1.5 | Standard Deviation 13.4 | milliseconds | |
| Change in Electrophysiology Measure of HV Interval | Oxytocin | 3.0 | Standard Deviation 9.2 | milliseconds | |
| Change in Electrophysiology Measure of HV Interval | Saline | 1.0 | Standard Deviation 6.0 | milliseconds | |
| Change in Electrophysiology Measure of Right Ventricular Refractory Period | Oxytocin | -30 | Standard Deviation 62.2 | milliseconds | |
| Change in Electrophysiology Measure of Right Ventricular Refractory Period | Saline | 5 | Standard Deviation 24.3 | milliseconds |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Oxytocin | 6 | |
| Overall Study | STARTED | Saline | 6 | |
| Overall Study | COMPLETED | Oxytocin | 6 | |
| Overall Study | COMPLETED | Saline | 6 | |
| Overall Study | NOT COMPLETED | Oxytocin | 0 | |
| Overall Study | NOT COMPLETED | Saline | 0 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Oxytocin | ||
| Total, all-cause mortality | Saline | ||
| Total, other adverse events | Oxytocin | 0 | 6 |
| Total, other adverse events | Saline | 0 | 6 |
| Total, serious adverse events | Oxytocin | 0 | 6 |
| Total, serious adverse events | Saline | 0 | 6 |
Source ClinicalTrials.gov
Papers15
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons1
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison |
|---|
| Oxytocin vs Saline: serious adverse events |
Source Trial comparisons
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT01780337
GET https://conductscience.org/api/trials/v1/NCT01780337/registered