Trial · NCT01782898
The Effect of Intraoperative Esmolol to Improve Postoperative Quality of Recovery and Pain After Ambulatory Surgery
NCT01782898, Not applicable, Completed, Northwestern University; results first posted 2016-04-04
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. The Effect of Intraoperative Esmolol to Improve Postoperative Quality of Recovery and Pain After Ambulatory Surgery. Trials, record NCT01782898. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT01782898
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- The Effect of Intraoperative Esmolol to Improve Postoperative Quality of Recovery and Pain After Ambulatory Surgery
- NCT number
- NCT01782898
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 70 participants, actual
- Lead sponsor
- Northwestern University
- Conditions
- Pain
- Interventions
- Esmolol administered at a rate of 0.5 mg/kg followed by an infusion of 5-15 mcg/kg/min, Placebo Comparator: .9 normal saline
- First posted
- 2013-02-04
- Last updated
- 2016-11-11
- Results first posted
- 2016-04-04
Source ClinicalTrials.gov
Registered outcomes3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Qor-40 at 24 Hours Postoperative | 24 hours | Quality of recovery questionnaire score at 24 hours after surgery. Quality of recovery score 24 hours after the surgical procedure.Score of 40 is poor recovery and a score of 200 is good recovery. Time frame for this evaluation is 24 hours after the surgical procedure |
| Secondary | Postoperative Opioid Consumption | 24 hours | The total amount of opioid consumed by subject at 24 hours after surgery measured in IV morphine equivalents. |
| Secondary | Post Operative Pain Reported by the Subject. | 24 hour | Post operative pain reported by the subject as determined as area under the numeric rating scale for pain versus time curve in the post anesthesia care unit ( score\*min).Numeric rating scale for pain on a scale of 0-10 (0 is no pain and 10 is high pain) versus time curve in the post anesthesia care unit ( score \* min). A higher value indicates more pain over 24 hours.The range is 0 pain to x time in minutes x hour ( 60-1440 minutes) . The pain scores were collected at 15 minute intervals from the time of admission to the PACU to 24 hours after the surgical procedure. The area under the NRS pain scale versus time curve was calculated using the trapezoidal method as an indicator of pain burden during early recovery (Graph Pad Prism ver 5.03, Graph Pad Software INC. |
Source ClinicalTrials.gov
Outcomes3
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Qor-40 at 24 Hours Postoperative | 24 hours | units on a scale 40 low-200 high | MEDIAN | |
| SECONDARY | Postoperative Opioid Consumption | 24 hours | IV mg of morpine equivalents | MEDIAN | |
| SECONDARY | Post Operative Pain Reported by the Subject. | 24 hour | (pain score * minutes ) in the PAC U | MEDIAN |
Source ClinicalTrials.gov
Results by group6
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Qor-40 at 24 Hours Postoperative | Esmolol | 179 | Inter-Quartile Range 171 to 190 | units on a scale 40 low-200 high | |
| Qor-40 at 24 Hours Postoperative | .9 Normal Saline | 182 | Inter-Quartile Range 173 to 189 | units on a scale 40 low-200 high | |
| Postoperative Opioid Consumption | Esmolol | 2.5 | Inter-Quartile Range 0 to 6 | IV mg of morpine equivalents | |
| Postoperative Opioid Consumption | .9 Normal Saline | 0 | Inter-Quartile Range 0 to 4 | IV mg of morpine equivalents | |
| Post Operative Pain Reported by the Subject. | Esmolol | 218 | Inter-Quartile Range 90 to 270 | (pain score * minutes ) in the PAC U | |
| Post Operative Pain Reported by the Subject. | .9 Normal Saline | 150 | Inter-Quartile Range 45 to 240 | (pain score * minutes ) in the PAC U |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Esmolol | 35 | |
| Overall Study | STARTED | .9 Normal Saline | 35 | |
| Overall Study | COMPLETED | Esmolol | 29 | |
| Overall Study | COMPLETED | .9 Normal Saline | 29 | |
| Overall Study | NOT COMPLETED | Esmolol | 6 | |
| Overall Study | NOT COMPLETED | .9 Normal Saline | 6 |
Source ClinicalTrials.gov
Adverse events4
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| other | Nausea | Gastrointestinal disorders | Esmolol | 9 | 29 | 9 |
| other | Nausea | Gastrointestinal disorders | .9 Normal Saline | 10 | 29 | 10 |
| other | Vomiting | Gastrointestinal disorders | Esmolol | 1 | 29 | 1 |
| other | Vomiting | Gastrointestinal disorders | .9 Normal Saline | 0 | 29 | 0 |
Source ClinicalTrials.gov
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Esmolol | ||
| Total, all-cause mortality | .9 Normal Saline | ||
| Total, other adverse events | Esmolol | 10 | 29 |
| Total, other adverse events | .9 Normal Saline | 10 | 29 |
| Total, serious adverse events | Esmolol | 0 | 29 |
| Total, serious adverse events | .9 Normal Saline | 0 | 29 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons1
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison |
|---|
| Esmolol vs .9 Normal Saline: serious adverse events |
Source Trial comparisons
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT01782898
GET https://conductscience.org/api/trials/v1/NCT01782898/registered