Trial · NCT01833455
Premature Ventricular Contractions (PVCs) and Blood Pressure Control
NCT01833455, Phase 2, Terminated, University of Wisconsin, Madison; results first posted 2019-02-22
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Premature Ventricular Contractions (PVCs) and Blood Pressure Control. Trials, record NCT01833455. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT01833455
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Premature Ventricular Contractions (PVCs) and Blood Pressure Control
- NCT number
- NCT01833455
- Status
- Terminated
- Phases
- Phase 2
- Enrollment
- 8 participants, actual
- Lead sponsor
- University of Wisconsin, Madison
- Conditions
- Ventricular Premature Complexes, Blood Pressure
- Interventions
- PVC Suppression using Flecainide, No PVC Suppression using Placebo
- First posted
- 2013-04-16
- Last updated
- 2019-02-22
- Results first posted
- 2019-02-22
- Limitations and caveats
This study was terminated prematurely due to a loss of staff available to make the technical measurements involved. The small number of data points available lead us to conclude the data is uninterpretable.
Source ClinicalTrials.gov
Registered outcomes3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in Mean Arterial Pressure | Baseline and 28 days | Mean arterial blood pressure was calculated from non-invasive systolic and diastolic arm measurements. |
| Secondary | Change in Muscle Sympathetic Nerve Activity | Baseline and 28 days | Muscle sympathetic nerve activity was measured as number of bursts of neural activity per 100 heart beats. |
| Other | Change in Baroreflex Gain | Baseline and 28 days | Arterial baroreflex gain is calculated as slope of the relationship between cardiac cycle length and the corresponding change in systolic blood pressure. |
Source ClinicalTrials.gov
Outcomes3
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Change in Mean Arterial Pressure | Baseline and 28 days | Mean arterial blood pressure values were not available at all time points for every patient. Data on subjects who completed the study is presented here and may not reflect changes seen in a larger population. | mmHg | MEAN |
| SECONDARY | Change in Muscle Sympathetic Nerve Activity | Baseline and 28 days | SNA values were not obtained in many of the participants in various groups above due to technical difficulties. Data on subjects who underwent the measurement are presented here and may not reflect changes seen in a larger population. | bursts / 100 heartbeats | NUMBER |
| OTHER_PRE_SPECIFIED | Change in Baroreflex Gain | Baseline and 28 days | Arterial baroreflex gain values were not available at all time points. In one subject, gain could not be calculated because they were in bigeminy. Data on subjects who completed the study is presented here and may not reflect changes seen in a larger population. | ms/mmHg | MEAN |
Source ClinicalTrials.gov
Results by group12
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Change in Mean Arterial Pressure | Change From Base 1 to PVC Suppression | 2 | Standard Deviation 2 | mmHg | |
| Change in Mean Arterial Pressure | Change From Base 2 to no PVC Suppression | 1 | Standard Deviation 4 | mmHg | |
| Change in Mean Arterial Pressure | Change From Base 1 to no PVC Suppression | 3 | Standard Deviation 11 | mmHg | |
| Change in Mean Arterial Pressure | Change From Base 2 to PVC Suppression | -4 | Standard Deviation 8 | mmHg | |
| Change in Muscle Sympathetic Nerve Activity | Change From Base 1 to PVC Suppression | 1 | bursts / 100 heartbeats | ||
| Change in Muscle Sympathetic Nerve Activity | Change From Base 2 to no PVC Suppression | -10 | bursts / 100 heartbeats | ||
| Change in Muscle Sympathetic Nerve Activity | Change From Base 1 to no PVC Suppression | -3 | bursts / 100 heartbeats | ||
| Change in Muscle Sympathetic Nerve Activity | Change From Base 2 to PVC Suppression | 15 | bursts / 100 heartbeats | ||
| Change in Baroreflex Gain | Change From Base 1 to PVC Suppression | 4 | Standard Deviation 1 | ms/mmHg | |
| Change in Baroreflex Gain | Change From Base 2 to no PVC Suppression | 6 | Standard Deviation 2 | ms/mmHg |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 results by groupParticipant flow12
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | PVC Suppression Then Placebo | 4 | |
| Overall Study | STARTED | Placebo Then PVC Suppression | 4 | |
| Overall Study | Completed 1st Baseline | PVC Suppression Then Placebo | 4 | |
| Overall Study | Completed 1st Baseline | Placebo Then PVC Suppression | 4 | |
| Overall Study | Completed 1st Intervention | PVC Suppression Then Placebo | 3 | |
| Overall Study | Completed 1st Intervention | Placebo Then PVC Suppression | 4 | |
| Overall Study | Completed 2nd Baseline (Washout) | PVC Suppression Then Placebo | 3 | |
| Overall Study | Completed 2nd Baseline (Washout) | Placebo Then PVC Suppression | 4 | |
| Overall Study | COMPLETED | PVC Suppression Then Placebo | 3 | |
| Overall Study | COMPLETED | Placebo Then PVC Suppression | 4 |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 participant flowAdverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals12
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Base 1 to PVC Suppression | 0 | 4 |
| Total, all-cause mortality | Base 2 to no PVC Suppression | 0 | 3 |
| Total, all-cause mortality | Base 1 to no PVC Suppression | 0 | 4 |
| Total, all-cause mortality | Base 2 to PVC Suppression | 0 | 4 |
| Total, other adverse events | Base 1 to PVC Suppression | 0 | 4 |
| Total, other adverse events | Base 2 to no PVC Suppression | 0 | 3 |
| Total, other adverse events | Base 1 to no PVC Suppression | 0 | 4 |
| Total, other adverse events | Base 2 to PVC Suppression | 0 | 4 |
| Total, serious adverse events | Base 1 to PVC Suppression | 0 | 4 |
| Total, serious adverse events | Base 2 to no PVC Suppression | 0 | 3 |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 adverse event totalsPapers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT01833455
GET https://conductscience.org/api/trials/v1/NCT01833455/registered