Trial · NCT01943513
A Study of the Effect of BIIB023 on Muscle Atrophy in Healthy Male Volunteers
NCT01943513, Phase 1, Completed, Biogen
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Study of the Effect of BIIB023 on Muscle Atrophy in Healthy Male Volunteers. Trials, record NCT01943513. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT01943513
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Study of the Effect of BIIB023 on Muscle Atrophy in Healthy Male Volunteers
- NCT number
- NCT01943513
- Status
- Completed
- Phases
- Phase 1
- Enrollment
- 34 participants, actual
- Lead sponsor
- Biogen
- Conditions
- Healthy
- Interventions
- BIIB023, Placebo
- First posted
- 2013-09-17
- Last updated
- 2014-09-03
Source ClinicalTrials.gov
Registered outcomes8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Percentage change in the magnitude of muscle atrophy | between Day 14 and Day 42 | |
| Secondary | Percentage change in the magnitude of muscle atrophy, measured by T1W-MRI analysis of the CSA of the triceps surae muscles of the immobilized limb | between Day 14 and Day 42 | |
| Secondary | Percentage change in isometric knee-extension strength (torque), measured by dynamometry | between Day 14 and Day 42 | |
| Secondary | Percentage change in isometric plantar-flexion strength (torque), measured by dynamometry | between Day 14 and Day 42 | |
| Secondary | Percentage change in total CSA of Type I and II fibers, measured by histological analysis of muscle biopsy | between Day 14, Day 21, and Day 42 | |
| Secondary | Change in density of satellite cells and other molecular markers of muscle regeneration, measured by histological analysis of muscle biopsy | between Day 14, Day 21, and Day 42 | |
| Secondary | Change in the recovery of muscle oxidative metabolism, measured by near-infrared spectroscopy (NIRS) of the quadriceps femoris muscles | between Day 14 and Day 42 | |
| Secondary | The number of participants that experience Adverse Events (AEs) and Serious Adverse Events (SAEs) | Day 156 |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT01943513
GET https://conductscience.org/api/trials/v1/NCT01943513/registered