Trial · NCT02007252

ACZ885 for the Treatment of Abdominal Aortic Aneurysm

NCT02007252, Phase 2, Terminated, Novartis Pharmaceuticals; results first posted 2016-11-21

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. ACZ885 for the Treatment of Abdominal Aortic Aneurysm. Trials, record NCT02007252. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02007252

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: ACZ885 for the Treatment of Abdominal Aortic Aneurysm
NCT number: NCT02007252
Status: Terminated
Phases: Phase 2
Enrollment: 65 participants, actual
Lead sponsor: Novartis Pharmaceuticals
Conditions: Abdominal Aortic Aneurysm (AAA)
Interventions: ACZ885, Placebo
First posted: 2013-12-10
Last updated: 2021-01-05
Other registries' IDs: eudract:2013-002088-25
Results first posted: 2016-11-21

Source ClinicalTrials.gov

Registered outcomes1

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Change From Baseline in Abdominal Aortic Aneurysm (AAA) Size Per Year	month 3, month 12	Size of the AAA was determined using an abdominal ultrasound technique at baseline, 3 months, and 12 months after treatment with study drug. Growth rate (in mm/year) was calculated from the change in AAA size compared to baseline

Source ClinicalTrials.gov

Outcomes1

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Population	Units	Measured as
PRIMARY	Change From Baseline in Abdominal Aortic Aneurysm (AAA) Size Per Year	month 3, month 12	The pharmacodynamic analysis set, which included randomized participants who received at least one dose of study drug, was considered for the analysis. However, only participants with values at each time point were analyzed.	millimeter/year	LEAST_SQUARES_MEAN

Source ClinicalTrials.gov

Results by group4

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Category	Value	Spread	Units
Change From Baseline in Abdominal Aortic Aneurysm (AAA) Size Per Year	ACZ885	Month 3 (n=23,31)	0.781	90% Confidence Interval -0.942 to 5.504	millimeter/year
Change From Baseline in Abdominal Aortic Aneurysm (AAA) Size Per Year	Placebo	Month 3 (n=23,31)	2.519	90% Confidence Interval 1.030 to 4.008	millimeter/year
Change From Baseline in Abdominal Aortic Aneurysm (AAA) Size Per Year	ACZ885	Month 12 (n=20,23)	2.538	90% Confidence Interval 1.465 to 3.612	millimeter/year
Change From Baseline in Abdominal Aortic Aneurysm (AAA) Size Per Year	Placebo	Month 12 (n=20,23)	2.581	90% Confidence Interval 1.612 to 3.549	millimeter/year

Source ClinicalTrials.gov

Participant flow10

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	ACZ885	31
Overall Study	STARTED	Placebo	33
Overall Study	Safety Analysis Set	ACZ885	31
Overall Study	Safety Analysis Set	Placebo	33
Overall Study	Pharmacodynamic Analysis Set	ACZ885	31
Overall Study	Pharmacodynamic Analysis Set	Placebo	33
Overall Study	COMPLETED	ACZ885	20
Overall Study	COMPLETED	Placebo	22
Overall Study	NOT COMPLETED	ACZ885	11
Overall Study	NOT COMPLETED	Placebo	11

Source ClinicalTrials.gov

Adverse events168

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk
other	Anaemia	Blood and lymphatic system disorders	ACZ885	1	31
other	Anaemia	Blood and lymphatic system disorders	Placebo	0	33
other	Angina pectoris	Cardiac disorders	ACZ885	0	31
other	Angina pectoris	Cardiac disorders	Placebo	2	33
other	Atrial fibrillation	Cardiac disorders	ACZ885	2	31
other	Atrial fibrillation	Cardiac disorders	Placebo	0	33
other	Atrioventricular block second degree	Cardiac disorders	ACZ885	0	31
other	Atrioventricular block second degree	Cardiac disorders	Placebo	1	33
other	Cataract	Eye disorders	ACZ885	0	31
other	Cataract	Eye disorders	Placebo	1	33

1 to 10 of 168Source ClinicalTrials.gov

See all 168 adverse events

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	ACZ885
Total, all-cause mortality	Placebo
Total, other adverse events	ACZ885	28	31
Total, other adverse events	Placebo	28	33
Total, serious adverse events	ACZ885	2	31
Total, serious adverse events	Placebo	0	33

Source ClinicalTrials.gov

Papers0

The papers the trial lists on ClinicalTrials.gov.

None in this release.

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons1

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison
ACZ885 vs Placebo: serious adverse events

Source Trial comparisons

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT02007252

GET https://conductscience.org/api/trials/v1/NCT02007252/events?page=2

API reference For AI assistants