Trial · NCT02007577
Beneficial Effect of Salicylates: Insulin Action, Secretion or Clearance?
NCT02007577, Not applicable, Completed, Stanford University; results first posted 2016-05-05
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Beneficial Effect of Salicylates: Insulin Action, Secretion or Clearance? Trials, record NCT02007577. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02007577
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Beneficial Effect of Salicylates: Insulin Action, Secretion or Clearance?
- NCT number
- NCT02007577
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 41 participants, actual
- Lead sponsor
- Stanford University
- Conditions
- Pre Diabetes, Insulin Resistant
- Interventions
- salsalate, Placebo
- First posted
- 2013-12-11
- Last updated
- 2016-05-05
- Results first posted
- 2016-05-05
Source ClinicalTrials.gov
Registered outcomes2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Quantification of Insulin Action With the Insulin Suppression Test (IST) | after treatment for one month | Compare changes in insulin sensitivity as assesses by the IST before and after treatment between salsalate and placebo group |
| Secondary | Quantification of Insulin Clearance With the Graded Glucose Infusion Test (GGIT) | one month on treatment | compare changes in insulin clearance as assessed by the GGIT before and after treatment with salsalate to placebo |
Source ClinicalTrials.gov
Outcomes2
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Quantification of Insulin Action With the Insulin Suppression Test (IST) | after treatment for one month | mmol/L | MEDIAN | |
| SECONDARY | Quantification of Insulin Clearance With the Graded Glucose Infusion Test (GGIT) | one month on treatment | pmol/min x 4h | MEDIAN |
Source ClinicalTrials.gov
Results by group4
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Quantification of Insulin Action With the Insulin Suppression Test (IST) | Salsalate 3500mg in 2 Divided Doses a Day | -3 | 95% Confidence Interval -10 to 5 | mmol/L | |
| Quantification of Insulin Action With the Insulin Suppression Test (IST) | Placebo | 2 | 95% Confidence Interval -9 to 12 | mmol/L | |
| Quantification of Insulin Clearance With the Graded Glucose Infusion Test (GGIT) | Salsalate 3500mg in 2 Divided Doses a Day | -6 | 95% Confidence Interval -12 to 0 | pmol/min x 4h | |
| Quantification of Insulin Clearance With the Graded Glucose Infusion Test (GGIT) | Placebo | 0 | 95% Confidence Interval -9 to 9 | pmol/min x 4h |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Salsalate 3500mg in 2 Divided Doses a Day | 27 | |
| Overall Study | STARTED | Placebo | 14 | |
| Overall Study | COMPLETED | Salsalate 3500mg in 2 Divided Doses a Day | 26 | |
| Overall Study | COMPLETED | Placebo | 13 | |
| Overall Study | NOT COMPLETED | Salsalate 3500mg in 2 Divided Doses a Day | 1 | |
| Overall Study | NOT COMPLETED | Placebo | 1 |
Source ClinicalTrials.gov
Adverse events4
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| other | 3 years | Gastrointestinal disorders | Salsalate 3500mg in 2 Divided Doses a Day | 1 | 27 | 1 |
| other | 3 years | Gastrointestinal disorders | Placebo | 0 | 14 | 0 |
| other | tinnitus | Ear and labyrinth disorders | Salsalate 3500mg in 2 Divided Doses a Day | 1 | 27 | 4 |
| other | tinnitus | Ear and labyrinth disorders | Placebo | 0 | 14 | 0 |
Source ClinicalTrials.gov
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Salsalate 3500mg in 2 Divided Doses a Day | ||
| Total, all-cause mortality | Placebo | ||
| Total, other adverse events | Salsalate 3500mg in 2 Divided Doses a Day | 1 | 27 |
| Total, other adverse events | Placebo | 0 | 14 |
| Total, serious adverse events | Salsalate 3500mg in 2 Divided Doses a Day | 0 | 27 |
| Total, serious adverse events | Placebo | 0 | 14 |
Source ClinicalTrials.gov
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 24963111 | DERIVED |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons1
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison |
|---|
| Salsalate 3500mg in 2 Divided Doses a Day vs Placebo: serious adverse events |
Source Trial comparisons
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02007577
GET https://conductscience.org/api/trials/v1/NCT02007577/registered