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Trial · NCT02070991

Results by group42

Each measurement the trial posted, group by group, in the words and numbers it posted.

OutcomeGroupCategoryValueSpreadUnits
Number of Participants Experiencing Significant Fluid Retention or Worsening in NYHA Functional Class (FC) up to End-of-treatmentMacitentanTotal participants with at least one condition7Participants
Number of Participants Experiencing Significant Fluid Retention or Worsening in NYHA Functional Class (FC) up to End-of-treatmentPlaceboTotal participants with at least one condition4Participants
Number of Participants Experiencing Significant Fluid Retention or Worsening in NYHA Functional Class (FC) up to End-of-treatmentMacitentanParticipants with fluid retention7Participants
Number of Participants Experiencing Significant Fluid Retention or Worsening in NYHA Functional Class (FC) up to End-of-treatmentPlaceboParticipants with fluid retention3Participants
Number of Participants Experiencing Significant Fluid Retention or Worsening in NYHA Functional Class (FC) up to End-of-treatmentMacitentanParticipants with worsening in NYHA FC1Participants
Number of Participants Experiencing Significant Fluid Retention or Worsening in NYHA Functional Class (FC) up to End-of-treatmentPlaceboParticipants with worsening in NYHA FC2Participants
Number of Participants Experiencing Significant Fluid Retention or Worsening in NYHA Functional Class (FC) up to End-of-treatmentMacitentanParticipants with both conditions1Participants
Number of Participants Experiencing Significant Fluid Retention or Worsening in NYHA Functional Class (FC) up to End-of-treatmentPlaceboParticipants with both conditions1Participants
NT-proBNP at Week 12 Expressed as Percent of Baseline NT-proBNP at RestMacitentan91.5695% Confidence Interval 72.37 to 115.83percentage of baseline NT-proBNP
NT-proBNP at Week 12 Expressed as Percent of Baseline NT-proBNP at RestPlacebo118.9095% Confidence Interval 92.53 to 152.78percentage of baseline NT-proBNP
PVR at Rest at Week 12 Expressed as Percent of Baseline PVR at RestMacitentan66.3195% Confidence Interval 56.15 to 78.30percentage of baseline PVR
PVR at Rest at Week 12 Expressed as Percent of Baseline PVR at RestPlacebo71.2395% Confidence Interval 51.35 to 98.81percentage of baseline PVR
Change From Baseline to Week 12 in Mean Pulmonary Arterial Pressure (mPAP)MacitentanmPAP at baseline44.695% Confidence Interval 40.7 to 48.6mmHg
Change From Baseline to Week 12 in Mean Pulmonary Arterial Pressure (mPAP)PlacebomPAP at baseline45.995% Confidence Interval 41.7 to 50.1mmHg
Change From Baseline to Week 12 in Mean Pulmonary Arterial Pressure (mPAP)MacitentanmPAP at Week 1241.195% Confidence Interval 36.2 to 46.0mmHg
Change From Baseline to Week 12 in Mean Pulmonary Arterial Pressure (mPAP)PlacebomPAP at Week 1242.195% Confidence Interval 37.5 to 46.7mmHg
Change From Baseline to Week 12 in Mean Pulmonary Arterial Pressure (mPAP)MacitentanChange in mPAP from baseline to Week 12-3.595% Confidence Interval -6.1 to -0.9mmHg
Change From Baseline to Week 12 in Mean Pulmonary Arterial Pressure (mPAP)PlaceboChange in mPAP from baseline to Week 12-3.895% Confidence Interval -7.5 to -0.1mmHg
Change From Baseline to Week 12 in Mean Right Atrial Pressure (mRAP)MacitentanmRAP at baseline12.195% Confidence Interval 10.0 to 14.3mmHg
Change From Baseline to Week 12 in Mean Right Atrial Pressure (mRAP)PlacebomRAP at baseline13.095% Confidence Interval 11.0 to 14.9mmHg

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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