Trial · NCT02100722
A Comparison of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention and Coronary Artery Bypass Graft Surgery in Patients With Multivessel Coronary Artery Disease
NCT02100722, Not applicable, Completed, Stanford University; results first posted 2022-01-20
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Comparison of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention and Coronary Artery Bypass Graft Surgery in Patients With Multivessel Coronary Artery Disease. Trials, record NCT02100722. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02100722
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Comparison of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention and Coronary Artery Bypass Graft Surgery in Patients With Multivessel Coronary Artery Disease
- NCT number
- NCT02100722
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 1,500 participants, actual
- Lead sponsor
- Stanford University
- Conditions
- Coronary Disease, Coronary Stenosis
- Interventions
- FFR guided PCI, CABG, Resolute Integrity Stent, Resolute Onyx Stent
- First posted
- 2014-04-01
- Last updated
- 2026-04-07
- Results first posted
- 2022-01-20
Source ClinicalTrials.gov
Registered outcomes17
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | MACCE | 1 year | Death, MI, stroke and any repeat revascularization (MACCE) will be evaluated at 1 year, where subjects contribute data from time of randomization until the occurrence of MACCE or one year follow-up, whichever occurs first. Subjects who die or are lost to follow up before 1 year will be censored at their last recorded activity. |
| Secondary | Key Secondary Outcome: Composite of Death From Any Cause, Myocardial Infarction, or Stroke | 3 years | Death, MI, or stroke at 3-year follow-up |
| Secondary | Number of Participants Experiencing Death, MI, or Stroke | 1 year | Subjects who died or are lost to follow up before this time were censored at their last recorded activity. |
| Secondary | Death | 1 year | Death evaluated excluding patients lost to follow-up from each arm |
| Secondary | Number of Participants Experiencing Myocardial Infarction | 1 year | MI evaluated excluding patients lost to follow-up from each arm |
| Secondary | Number of Participants Experiencing Stroke | 1 year | Stroke evaluated excluding patients lost to follow-up from each arm. |
| Secondary | Number of Participants Requiring Repeat Revascularization | 1 year | Any repeat revascularization evaluated excluding patients lost to follow-up from each arm |
| Secondary | Number of Participants Experiencing BARC Type 3-5 Bleeding | 1 year | Bleeding Academic Research Consortium (BARC) type 3-5 indicates severe bleeding. |
| Secondary | Number of Participants Experiencing Acute Kidney Injury | 1 year | |
| Secondary | Number of Participants Experiencing Atrial Fibrillation or Clinically Significant Arrhythmia | 1 year |
1 to 10 of 17Source ClinicalTrials.gov
See all 17 registered outcomesOutcomes16
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | MACCE | 1 year | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Key Secondary Outcome: Composite of Death From Any Cause, Myocardial Infarction, or Stroke | 3 years | FFR-guided PCI vs CABG | Participants | COUNT_OF_PARTICIPANTS |
| SECONDARY | Number of Participants Experiencing Death, MI, or Stroke | 1 year | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Death | 1 year | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Number of Participants Experiencing Myocardial Infarction | 1 year | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Number of Participants Experiencing Stroke | 1 year | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Number of Participants Requiring Repeat Revascularization | 1 year | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Number of Participants Experiencing BARC Type 3-5 Bleeding | 1 year | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Number of Participants Experiencing Acute Kidney Injury | 1 year | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Number of Participants Experiencing Atrial Fibrillation or Clinically Significant Arrhythmia | 1 year | Participants | COUNT_OF_PARTICIPANTS |
1 to 10 of 16Source ClinicalTrials.gov
See all 16 outcomesResults by group44
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| MACCE | FFR Guided PCI | 80 | Participants | ||
| MACCE | CABG | 51 | Participants | ||
| Key Secondary Outcome: Composite of Death From Any Cause, Myocardial Infarction, or Stroke | FFR Guided PCI | 91 | Participants | ||
| Key Secondary Outcome: Composite of Death From Any Cause, Myocardial Infarction, or Stroke | CABG | 68 | Participants | ||
| Number of Participants Experiencing Death, MI, or Stroke | FFR Guided PCI | 55 | Participants | ||
| Number of Participants Experiencing Death, MI, or Stroke | CABG | 39 | Participants | ||
| Death | FFR Guided PCI | Death | 12 | Participants | |
| Death | CABG | Death | 7 | Participants | |
| Death | FFR Guided PCI | Death from cardiac causes | 6 | Participants | |
| Death | CABG | Death from cardiac causes | 4 | Participants |
1 to 10 of 44Source ClinicalTrials.gov
See all 44 results by groupParticipant flow8
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | FFR Guided PCI | 757 | |
| Overall Study | STARTED | CABG | 743 | |
| Overall Study | Underwent alternate procedure | FFR Guided PCI | 11 | |
| Overall Study | Underwent alternate procedure | CABG | 37 | |
| Overall Study | COMPLETED | FFR Guided PCI | 724 | |
| Overall Study | COMPLETED | CABG | 696 | |
| Overall Study | NOT COMPLETED | FFR Guided PCI | 33 | |
| Overall Study | NOT COMPLETED | CABG | 47 |
Source ClinicalTrials.gov
Adverse events4
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| other | Repeat revascularization | Cardiac disorders | FFR Guided PCI | 45 | 757 | |
| other | Repeat revascularization | Cardiac disorders | CABG | 29 | 743 | |
| serious | Death, MI or stroke | Cardiac disorders | FFR Guided PCI | 119 | 757 | |
| serious | Death, MI or stroke | Cardiac disorders | CABG | 101 | 743 |
Source ClinicalTrials.gov
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | FFR Guided PCI | 31 | 757 |
| Total, all-cause mortality | CABG | 29 | 743 |
| Total, other adverse events | FFR Guided PCI | 45 | 757 |
| Total, other adverse events | CABG | 29 | 743 |
| Total, serious adverse events | FFR Guided PCI | 119 | 757 |
| Total, serious adverse events | CABG | 101 | 743 |
Source ClinicalTrials.gov
Papers11
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons12
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| FFR Guided PCI vs CABG: Number of Participants Experiencing Stroke | Trial comparisons |
| FFR Guided PCI vs CABG: Number of Participants Experiencing BARC Type 3-5 Bleeding | Trial comparisons |
| FFR Guided PCI vs CABG: Death, MI, or Stroke at 5 Years | Trial comparisons |
| FFR Guided PCI vs CABG: Number of Participants Experiencing Death, MI, or Stroke | Trial comparisons |
| FFR Guided PCI vs CABG: Number of Participants Requiring Rehospitalization Within 30 Days | Trial comparisons |
| FFR Guided PCI vs CABG: MACCE | Trial comparisons |
| FFR Guided PCI vs CABG: Key Secondary Outcome: Composite of Death From Any Cause, Myocardial Infarction, or Stroke | Trial comparisons |
| FFR Guided PCI vs CABG: Number of Participants Experiencing Atrial Fibrillation or Clinically Significant Arrhythmia | Trial comparisons |
| FFR Guided PCI vs CABG: Number of Participants Experiencing Acute Kidney Injury | Trial comparisons |
| FFR Guided PCI vs CABG: MACCE | Trial comparisons |
1 to 10 of 12
See all 12 trial comparisonsTests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02100722
GET https://conductscience.org/api/trials/v1/NCT02100722/results?page=2