Trial · NCT02102100
The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users
NCT02102100, Not applicable, Completed, Yale University; results first posted 2019-02-20
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users. Trials, record NCT02102100. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02102100
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users
- NCT number
- NCT02102100
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 57 participants, actual
- Lead sponsor
- Yale University
- Conditions
- Nicotine Dependence
- Interventions
- nicotine, menthol
- First posted
- 2014-04-02
- Last updated
- 2020-03-19
- Results first posted
- 2019-02-20
Source ClinicalTrials.gov
Registered outcomes1
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Drug Effects Questionnaire (DEQ)- 'Good Drug Effects' | up to 55 minutes post-infusion | The Drug Effects Questionnaire (DEQ) is used in studies of acute subjective response (SR) to a variety of substances. The DEQ consists of 11 questions: cooling effect, dislike the sensation, any sensations, feel a drug effect, high, feel stimulated, feel a head rush, like drug effect, dislike any effects, craving a cigarette, and like more of the drug. To calculate the DEQ- 'Good Drug Effects', peak values from post-infusion time points were calculated for the change in the intensity of positive subjective effects as measured with 2 DEQ questions - DEQ question #6 'like drug effect' and DEQ question #11 'would like more of the drug'. Each question was measured on a scale with a minimum score of 0 and a maximum score of 100.The peak values for "like" and " I want more" were averaged to obtain a summary score to represent the feel 'Good Drug Effects' composite factor. DEQ measures were skewed and square root transformations were used. Higher scores indicate more positive effects. |
Source ClinicalTrials.gov
Outcomes1
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Drug Effects Questionnaire (DEQ)- 'Good Drug Effects' | up to 55 minutes post-infusion | scores on a scale | LEAST_SQUARES_MEAN |
Source ClinicalTrials.gov
Results by group14
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Drug Effects Questionnaire (DEQ)- 'Good Drug Effects' | Menthol-Preferring Smokers | Across Conditions (main effect) | 5.1979 | Standard Error 0.3803 | scores on a scale |
| Drug Effects Questionnaire (DEQ)- 'Good Drug Effects' | Non-Menthol Preferring Smokers | Across Conditions (main effect) | 6.8384 | Standard Error 0.4292 | scores on a scale |
| Drug Effects Questionnaire (DEQ)- 'Good Drug Effects' | Menthol-Preferring Smokers | High Menthol w High Nicotine | 5.6235 | Standard Error 0.4731 | scores on a scale |
| Drug Effects Questionnaire (DEQ)- 'Good Drug Effects' | Non-Menthol Preferring Smokers | High Menthol w High Nicotine | 7.6285 | Standard Error 0.5287 | scores on a scale |
| Drug Effects Questionnaire (DEQ)- 'Good Drug Effects' | Menthol-Preferring Smokers | High Menthol w Low Nicotine | 5.226 | Standard Error 0.4766 | scores on a scale |
| Drug Effects Questionnaire (DEQ)- 'Good Drug Effects' | Non-Menthol Preferring Smokers | High Menthol w Low Nicotine | 7.4351 | Standard Error 0.5302 | scores on a scale |
| Drug Effects Questionnaire (DEQ)- 'Good Drug Effects' | Menthol-Preferring Smokers | High Menthol w Saline | 5.0699 | Standard Error 0.4768 | scores on a scale |
| Drug Effects Questionnaire (DEQ)- 'Good Drug Effects' | Non-Menthol Preferring Smokers | High Menthol w Saline | 7.6285 | Standard Error 0.5287 | scores on a scale |
| Drug Effects Questionnaire (DEQ)- 'Good Drug Effects' | Menthol-Preferring Smokers | Low Menthol w High Nicotine | 5.8971 | Standard Error 0.4736 | scores on a scale |
| Drug Effects Questionnaire (DEQ)- 'Good Drug Effects' | Non-Menthol Preferring Smokers | Low Menthol w High Nicotine | 7.5808 | Standard Error 0.5346 | scores on a scale |
1 to 10 of 14Source ClinicalTrials.gov
See all 14 results by groupParticipant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Menthol-Preferring Smokers | 32 | |
| Overall Study | STARTED | Non-Methol Preferring Smokers | 25 | |
| Overall Study | COMPLETED | Menthol-Preferring Smokers | 23 | |
| Overall Study | COMPLETED | Non-Methol Preferring Smokers | 18 | |
| Overall Study | NOT COMPLETED | Menthol-Preferring Smokers | 9 | |
| Overall Study | NOT COMPLETED | Non-Methol Preferring Smokers | 7 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Menthol-Preferring Smokers | 0 | 32 |
| Total, all-cause mortality | Non-Menthol Preferring Smokers | 0 | 25 |
| Total, other adverse events | Menthol-Preferring Smokers | 0 | 32 |
| Total, other adverse events | Non-Menthol Preferring Smokers | 0 | 25 |
| Total, serious adverse events | Menthol-Preferring Smokers | 0 | 32 |
| Total, serious adverse events | Non-Menthol Preferring Smokers | 0 | 25 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| P50DA036151 | Yale Tobacco Center of Regulatory Science | KRISHNAN-SARIN, SUCHITRA; O'MALLEY, STEPHANIE S | YALE UNIVERSITY | NATIONAL INSTITUTE ON DRUG ABUSE | 2013 to 2017 |
Source NIH RePORTER
Trial comparisons2
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Menthol-Preferring Smokers vs Non-Menthol Preferring Smokers: deaths from any cause | Trial comparisons |
| Menthol-Preferring Smokers vs Non-Menthol Preferring Smokers: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02102100
GET https://conductscience.org/api/trials/v1/NCT02102100/registered