Registered outcomes21

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

1 to 20 of 21

List	Outcome	Time frame	Description
Primary	Modified Change in Sequential Organ Failure Assessment (mSOFA) Score	96 hours	mSOFA is a single score based on patient status of five different biological systems: respiratory, cardiovascular, coagulation, renal, and neurological. Scores range from 0 to 20 with higher scores indicated worse status.
Primary	C-Reactive Protein at Study Hours 0, 48, 96, 168 When Compared to Placebo	up to 168 hours
Primary	Thrombomodulin Protein at Study Hours 0, 48, 96, 168 When Compared to Placebo	Up to 168 hours
Secondary	Oxygenation Index (FiO2 x Mean Airway Pressure/PaO2) at Study Hour 0, 48, 96, 168 if Still Intubated in Ascorbate Infused Patient Compared to Placebo.	Up to hour 168
Secondary	VE-40 (Vent RR x TV/Weight) x (PaCO2/40) at Study Hour 0, 48, 96, 168 if Still Intubated, in Ascorbate Infused Patient Compared to Placebo	Up to hour 168	Estimate of Shunt
Secondary	mSOFA Scores at Hours 0, 48, 96	Up to hour 96	mSOFA is a single score based on patient status of five different biological systems: respiratory, cardiovascular, coagulation, renal, and neurological. Scores range from 0 to 20 with higher scores indicated worse status.
Secondary	Ascorbate Level at Hour 0, 48, 96, 168	Up to hour 168
Secondary	Ventilator Free Days to Day 28	Up to Day 28
Secondary	ICU-free Days at Day 28	Up to Day 28
Secondary	All Cause Mortality to Day 28	Up to Day 28
Secondary	Hospital-free Days at Day 60	Up to Day 60
Secondary	Procalcitonin at Study Hour 0, 48, 96, 168	Up to hour 168
Secondary	Receptor for Advanced Glycation Endpoints at Study Hour 0, 48, 96, 168	Up to hour 168
Secondary	Tissue Factor Pathway Inhibitor at Study Hour 0, 48, 96, 168	Up to hour 168
Secondary	Oxygenation Score: Pressure	Up to hour 168	Oxygenation as measure by the ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO2/FiO2). Scores range from 100 to 300 with lower values indicating more worse outcomes
Secondary	Oxygenation Score: Saturation	Up to hour 168	Oxygenation as measure by the ratio of arterial oxygen saturation to fraction of inspired oxygen SpO2/FiO2
Secondary	Coagulation	Up to hour 168	Coagulation as measured by Platelets per unit of blood. Scores range from less than 20 to more than 150. Lower scores indicate worse outcomes
Secondary	Liver Function	Up to hour 168	Liver function as measured by Total Bilirubin. Normal levels range from 0.2 - 1.2. Levels greater than 1.2 indicate worse outcomes
Secondary	Cardiovascular Function	Up to hour 168	Cardiovascular function as measured by Mean arterial pressure. Scores less than 70 mmHg indicate worse outcomes.
Secondary	State of Consciousness	Up to hour 168	State of consciousness as measure by Glasgow Coma Scale which gives a score based on eye, verbal, and motor responses. Scores range from 3 to 15 with lower scores indicating worse outcome

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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Registered outcomes21

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