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Trial · NCT02117713

Outcomes11

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

TypeOutcomeTime framePopulationUnitsMeasured as
PRIMARYChange From MRX Baseline to Week 48 in Fasting Serum Bile Acid (sBA)Baseline to Week 48Since most participants escalated to MRX 280 ug/kg/day, the summary is presented as a single arm.μmol/LMEAN
SECONDARYChange From MRX Baseline to Week 216 in Fasting Serum Bile Acid (sBA)Baseline to week 216Since most participants escalated to MRX 280 ug/kg/day, the summary is presented as a single arm.μmol/LMEAN
SECONDARYChange From Baseline to Week 218 in PruritusBaseline to Week 218Since most participants escalated to MRX 280 ug/kg/day, the summary is presented as a single arm.score on a scaleMEAN
SECONDARYChange From Baseline to Week 216 in Alanine AminotransferaseBaseline to week 216Since most participants escalated to MRX 280 ug/kg/day, the summary is presented as a single arm.U/LMEAN
SECONDARYChange From Baseline to End of Treatment in Alkaline PhosphataseBaseline to Week 216Since most participants escalated to MRX 280 ug/kg/day, the summary is presented as a single arm.U/LMEAN
SECONDARYChange From MRX Baseline to Week 216 in Aspartate AminotransferaseBaseline to week 216Since most participants escalated to MRX 280 ug/kg/day, the summary is presented as a single arm.U/LMEAN
SECONDARYChange From MRX Baseline to Week 216 in Clinician Xanthoma Severity ScoreBaseline to week 216Since most participants escalated to MRX 280 ug/kg/day, the summary is presented as a single arm.PointsMEAN
SECONDARYChange From Baseline to Week 216/LOFC Clinician Scratch Scale (CSS) ScoreBaseline to Week 216Since most participants escalated to MRX 280 ug/kg/day, the summary is presented as a single arm.PointsMEAN
SECONDARYChange From MRX Baseline to Week 216 in Gamma GlutamyltransferaseBaseline to Week 216Since most participants escalated to MRX 280 ug/kg/day, the summary is presented as a single arm.U/LMEAN
SECONDARYMean Change From MRX Baseline to Week 216 in Total BilirubinBaseline to week 216Since most participants escalated to MRX 280 ug/kg/day, the summary is presented as a single arm.mg/dLMEAN
SECONDARYMean Change From MRX Baseline to Week 216 in Direct BilirubinBaseline to week 216Since most participants escalated to MRX 280 ug/kg/day, the summary is presented as a single arm.mg/dLMEAN

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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