Trial · NCT02119416
Gender Difference in Response to Caffeine in Children and Adolescents
NCT02119416, Not applicable, Completed, State University of New York at Buffalo; results first posted 2022-08-17
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Gender Difference in Response to Caffeine in Children and Adolescents. Trials, record NCT02119416. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02119416
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Gender Difference in Response to Caffeine in Children and Adolescents
- NCT number
- NCT02119416
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 101 participants, actual
- Lead sponsor
- State University of New York at Buffalo
- Conditions
- Healthy
- Interventions
- Placebo Administration first, Low Caffeine Administration first (1mg/kg body weight), High Caffeine Administration first (2mg/kg body weight)
- First posted
- 2014-04-21
- Last updated
- 2022-08-17
- Results first posted
- 2022-08-17
Source ClinicalTrials.gov
Registered outcomes2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Peak Heart Rate After 2 mg/kg of Caffeine | Heart rate was collected every 10 minutes for 60 minutes after the dose of caffeine. | Heart rate measurements were taken every 10 minutes, following 1 minute of rest with an automated Welch Allen Blood Pressure Cuff. We have reported the data as the peak heart rate after 2 mg/kg. |
| Primary | Peak Systolic Blood Pressure | Blood pressure was assessed every 10 minutes for 60 minutes after caffeine was administered. | Blood pressure measurements were taken every 10 minutes, following 1 minute of rest with an automated Welch Allen Blood Pressure Cuff. We have reported the peak heart rate after the 2 mg/kg dose of caffeine. |
Source ClinicalTrials.gov
Outcomes2
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Peak Heart Rate After 2 mg/kg of Caffeine | Heart rate was collected every 10 minutes for 60 minutes after the dose of caffeine. | beats per minute | MEAN | |
| PRIMARY | Peak Systolic Blood Pressure | Blood pressure was assessed every 10 minutes for 60 minutes after caffeine was administered. | Participants were randomized to a particular order, but this was a crossover design. | mmHg | MEAN |
Source ClinicalTrials.gov
Results by group6
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Peak Heart Rate After 2 mg/kg of Caffeine | 1mg/kg Caffeine Then 2 mg/kg Then 0 mg/kg | 73.6 | Standard Error 2.32 | beats per minute | |
| Peak Heart Rate After 2 mg/kg of Caffeine | 2mg/kg Caffeine Then 0 mg/kg Then 1 mg/kg | 73.2 | Standard Error 1.6 | beats per minute | |
| Peak Heart Rate After 2 mg/kg of Caffeine | 0 mg/kg Then 1 mg/kg Then 2 mg/kg | 79.6 | Standard Error 2.64 | beats per minute | |
| Peak Systolic Blood Pressure | 1mg/kg Caffeine Then 2 mg/kg Than 0 mg/kg | 107.6 | Standard Error 1.82 | mmHg | |
| Peak Systolic Blood Pressure | 2mg/kg Caffeine Than 0 mg/kg Than 1 mg/kg | 112.3 | Standard Error 1.69 | mmHg | |
| Peak Systolic Blood Pressure | 0 mg/kg Than 1 mg/kg Than 2 mg/kg | 109.6 | Standard Error 2.09 | mmHg |
Source ClinicalTrials.gov
Participant flow9
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | 1mg/kg Caffeine | 32 | |
| Overall Study | STARTED | 2mg/kg Caffeine | 36 | |
| Overall Study | STARTED | Placebo | 33 | |
| Overall Study | COMPLETED | 1mg/kg Caffeine | 30 | |
| Overall Study | COMPLETED | 2mg/kg Caffeine | 35 | |
| Overall Study | COMPLETED | Placebo | 31 | |
| Overall Study | NOT COMPLETED | 1mg/kg Caffeine | 2 | |
| Overall Study | NOT COMPLETED | 2mg/kg Caffeine | 1 | |
| Overall Study | NOT COMPLETED | Placebo | 2 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals9
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | 1mg/kg Caffeine | 0 | 96 |
| Total, all-cause mortality | 2mg/kg Caffeine | 0 | 96 |
| Total, all-cause mortality | Placebo | 0 | 96 |
| Total, other adverse events | 1mg/kg Caffeine | 0 | 96 |
| Total, other adverse events | 2mg/kg Caffeine | 0 | 96 |
| Total, other adverse events | Placebo | 0 | 96 |
| Total, serious adverse events | 1mg/kg Caffeine | 0 | 96 |
| Total, serious adverse events | 2mg/kg Caffeine | 0 | 96 |
| Total, serious adverse events | Placebo | 0 | 96 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| R01DA030386 | Gender Differences in Responses to Caffeine in Children and Adolescents | TEMPLE, JENNIFER L | STATE UNIVERSITY OF NEW YORK AT BUFFALO | NATIONAL INSTITUTE ON DRUG ABUSE | 2011 to 2015 |
Source NIH RePORTER
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02119416
GET https://conductscience.org/api/trials/v1/NCT02119416/registered