Trial · NCT02126020
Topical Infliximab in Autoimmune Eyes With Keratoprosthesis
NCT02126020, Phase 1, Phase 2, Withdrawn, James Chodosh, MD, MPH
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Topical Infliximab in Autoimmune Eyes With Keratoprosthesis. Trials, record NCT02126020. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02126020
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Topical Infliximab in Autoimmune Eyes With Keratoprosthesis
- NCT number
- NCT02126020
- Status
- Withdrawn
- Phases
- Phase 1, Phase 2
- Enrollment
- 0 participants, actual
- Lead sponsor
- James Chodosh, MD, MPH
- Conditions
- Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis (Lyell) Syndrome, Mucous Membrane Pemphigoid
- Interventions
- topical infliximab
- First posted
- 2014-04-29
- Last updated
- 2017-04-07
Source ClinicalTrials.gov
Registered outcomes9
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Tolerability | 1 year | Percentage of patients finishing 12 months of topical infliximab use |
| Primary | Adverse events | 2 years | Number and type of adverse events |
| Primary | rate of corneal melting | 2 years | rate of corneal melting or ulceration during infliximab prophylaxis (12 months) and after the drug is stopped (following 12 months) |
| Primary | KPro retention | 2 years | Percentage of retained KPros at 2 years |
| Secondary | Visual acuity | 2 years | |
| Secondary | Ocular surface symptoms | 2 years | Ocular surface symptoms as assessed by ocular surface disease index score |
| Secondary | Ocular surface inflammation | 2 years | Ocular surface inflammation using slit-lamp photographs and the ocular redness index (ORI) |
| Secondary | tear matrix metalloproteinase (MMP) | 2 years | Levels and activity of MMPs, myeloperoxidase and tissue inhibitor of MMP-1 |
| Secondary | graft thickness | 2 years | Corneal carrier graft thickness as measured by anterior segment optical coherence tomography before, during and after treatment with infliximab |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02126020
GET https://conductscience.org/api/trials/v1/NCT02126020/registered