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Trial · NCT02152995

Outcomes15

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

TypeOutcomeTime framePopulationUnitsMeasured as
PRIMARYPercentage of Patients Progression Free at 6 Months Following Treatment With Trametinib and I-124 (Cohort A)At 6 months% of pts progression free at 6 monthsNUMBER
PRIMARYProgression Free Survival (Cohort A)At 6 monthsParticipantsCOUNT_OF_PARTICIPANTS
PRIMARYPercentage With Objective Response (Complete Response or Partial Response) (Cohort A)At 6 months% of pts with confirmed partial responseNUMBER
PRIMARYIodine Incorporation in Thyroid Cancer Metastases to a Predicted Lesional Absorbed Radiation Dose Equal to or Exceeding 2,000 cGy With the Administration of =< 300 mCi Radioiodine (RAI) (Cohort B)Up to 6 monthsParticipantsCOUNT_OF_PARTICIPANTS
SECONDARYAdequate Increase in Iodine Corporation (Cohort A)Up to 6 monthsParticipantsCOUNT_OF_PARTICIPANTS
SECONDARYChanges in ThyroglobulinBaseline to up to 6 monthsData were not collected
SECONDARYNumber of Participants With Toxicity (Cohort A)Up to 30 days after completion of treatmentParticipantsCOUNT_OF_PARTICIPANTS
SECONDARYPercentage With an Objective Response (Complete Response or Partial Response) (Cohort B)At 6 months% of pts with confirmed partial responseNUMBER
SECONDARYPercentage of Patients Alive Without Disease Progression (Cohort B)At 6 months% of pts progression free at 6 monthsNUMBER
SECONDARYChange in Thyroglobulin (Cohort B)Baseline up to 6 monthsData were not collected
SECONDARYNumber of Participants With Toxicity (Cohort B)Up to 30 days after completion of treatmentParticipantsCOUNT_OF_PARTICIPANTS
OTHER_PRE_SPECIFIEDExpression and Phosphorylation of MAPK Signaling Pathway ProteinsUp to 6 monthsData were not collected
OTHER_PRE_SPECIFIEDExpression and Phosphorylation of Negative Feedback Loops Connected to the MAPK Pathway (Such as Human Epidermal Growth Factor 3)Up to 6 monthsData were not collected
OTHER_PRE_SPECIFIEDQuantitative Levels of Messenger Ribonucleic Acid Transcripts for MAPK Regulated and Thyroid-specific Gene ProductsUp to 6 monthsData were not collected
OTHER_PRE_SPECIFIEDPresence of Other Genetic AlterationsUp to 6 monthsData were not collected

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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