Trial · NCT02216812
Does Vitamin C Reduce Finger Stiffness After Distal Radius Fractures?
NCT02216812, Not applicable, Completed, Massachusetts General Hospital; results first posted 2018-09-17
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Does Vitamin C Reduce Finger Stiffness After Distal Radius Fractures? Trials, record NCT02216812. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02216812
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Does Vitamin C Reduce Finger Stiffness After Distal Radius Fractures?
- NCT number
- NCT02216812
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 134 participants, actual
- Lead sponsor
- Massachusetts General Hospital
- Conditions
- Finger Stiffness, Distal Radius Fracture
- Interventions
- 500 mg vitamin c, 1 pill per day for 6 weeks, 1 placebo pill for 6 weeks
- First posted
- 2014-08-15
- Last updated
- 2019-08-14
- Results first posted
- 2018-09-17
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Distance to Palmar Crease Index Through Small Finger | Day 1 (baseline), 6 weeks | To establish the distance to palmar crease, we asked patients to make a fist and determine the distance from nail tip to palmar crease for each individual digit using a ruler. We defined total distance to palmar crease as the sum of the values for the index, long, ring, and small fingers. |
| Secondary | Active Flexion Index Through Small Finger | Day 1 (baseline), 6 weeks | Active flexion will be measured using a handheld goniometer. We calculate total active flexion of the index through small finger by summing flexion at the metacarpo-phalangeal, proximal interphalangeal and distal interphalangeal joints |
| Secondary | Thumb Motion | Day 1 (baseline), 6 weeks | Total active range of motion at the thumb combines active flexion at the metacarpo-phalangeal and interphalangeal joint, as well as palmar andabduction |
| Secondary | PROMIS Upper Extremity - CAT | Day 1 (baseline), 6 weeks, 6 months | The Patient Reported Outcome Information System (PROMIS) Upper Extremity Computer Adaptive Test (CAT) is a computerized assessment measuring the physical function of the upper extremity. It is scored using a T-score, and the average is 50 for the U.S. population. In a given PROMIS, a T-score above 50 represents more of the measured variable than the average. For this variable, a T-score above 50 indicates greater physical function than the average population. |
| Secondary | 0-10 Ordinal Pain Score | Day 1 (baseline), 6 weeks, 6 months | Measure Description: The Ordinal Pain Scale measures the amount of pain on a scale from 0, no pain, to 10, worst possible pain. The investigators will compare the change in pain between the two cohorts after 6 weeks of treatment and 6 months after treatment. |
Source ClinicalTrials.gov
Outcomes5
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Distance to Palmar Crease Index Through Small Finger | Day 1 (baseline), 6 weeks | Some subjects were lost to follow up between enrollment, 6 week visit, and 6 month surveys. | Centimeters | MEAN |
| SECONDARY | Active Flexion Index Through Small Finger | Day 1 (baseline), 6 weeks | Some subjects were lost to follow up between enrollment, 6 week visit, and 6 month surveys. | Degrees | MEAN |
| SECONDARY | Thumb Motion | Day 1 (baseline), 6 weeks | Some subjects were lost to follow up between enrollment, 6 week visit, and 6 month surveys. | Degrees | MEAN |
| SECONDARY | PROMIS Upper Extremity - CAT | Day 1 (baseline), 6 weeks, 6 months | Some subjects were lost to follow up between enrollment, 6 week visit, and 6 month surveys. | T-score | MEAN |
| SECONDARY | 0-10 Ordinal Pain Score | Day 1 (baseline), 6 weeks, 6 months | Some subjects were lost to follow up between time of enrollment and 6 week and 6 month follow up | units on a scale | MEAN |
Source ClinicalTrials.gov
Results by group24
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Distance to Palmar Crease Index Through Small Finger | 500 mg Vitamin C | Day 1 (baseline) | 6.7 | Standard Deviation 6.7 | Centimeters |
| Distance to Palmar Crease Index Through Small Finger | Placebo | Day 1 (baseline) | 7.1 | Standard Deviation 6.0 | Centimeters |
| Distance to Palmar Crease Index Through Small Finger | 500 mg Vitamin C | 6 weeks | 2.3 | Standard Deviation 4.0 | Centimeters |
| Distance to Palmar Crease Index Through Small Finger | Placebo | 6 weeks | 2.0 | Standard Deviation 3.8 | Centimeters |
| Active Flexion Index Through Small Finger | 500 mg Vitamin C | Day 1 (baseline) | 725 | Standard Deviation 159 | Degrees |
| Active Flexion Index Through Small Finger | Placebo | Day 1 (baseline) | 732 | Standard Deviation 144 | Degrees |
| Active Flexion Index Through Small Finger | 500 mg Vitamin C | 6 weeks | 896 | Standard Deviation 108 | Degrees |
| Active Flexion Index Through Small Finger | Placebo | 6 weeks | 904 | Standard Deviation 132 | Degrees |
| Thumb Motion | 500 mg Vitamin C | Day 1 (baseline) | 161 | Standard Deviation 59 | Degrees |
| Thumb Motion | Placebo | Day 1 (baseline) | 155 | Standard Deviation 49 | Degrees |
1 to 10 of 24Source ClinicalTrials.gov
See all 24 results by groupParticipant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | 500 mg Vitamin C | 67 | |
| Overall Study | STARTED | Placebo | 67 | |
| Overall Study | COMPLETED | 500 mg Vitamin C | 57 | |
| Overall Study | COMPLETED | Placebo | 62 | |
| Overall Study | NOT COMPLETED | 500 mg Vitamin C | 10 | |
| Overall Study | NOT COMPLETED | Placebo | 5 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | 500 mg Vitamin C | 0 | 67 |
| Total, all-cause mortality | Placebo | 0 | 67 |
| Total, other adverse events | 500 mg Vitamin C | 0 | 67 |
| Total, other adverse events | Placebo | 0 | 67 |
| Total, serious adverse events | 500 mg Vitamin C | 0 | 67 |
| Total, serious adverse events | Placebo | 0 | 67 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons2
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| 500 mg Vitamin C vs Placebo: deaths from any cause | Trial comparisons |
| 500 mg Vitamin C vs Placebo: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02216812
GET https://conductscience.org/api/trials/v1/NCT02216812/results?page=2