Trial · NCT02223377
Satisfactory Analgesia Minimal Emesis in Day Surgeries
NCT02223377, Not applicable, Completed, McMaster University; results first posted 2023-12-11
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Satisfactory Analgesia Minimal Emesis in Day Surgeries. Trials, record NCT02223377. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02223377
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Satisfactory Analgesia Minimal Emesis in Day Surgeries
- NCT number
- NCT02223377
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 402 participants, actual
- Lead sponsor
- McMaster University
- Conditions
- Pain, Post Operative Nausea and Vomiting
- Interventions
- Morphine, Hydromorphone
- First posted
- 2014-08-22
- Last updated
- 2026-06-23
- Results first posted
- 2023-12-11
Source ClinicalTrials.gov
Registered outcomes9
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Our Combined Primary Outcome Will be Number of Patients With Same Analgesia Minimal Emesis, as Compared Between the 2 Groups. | At 2hrs or at the time of discharge from PACU | Our combined primary outcome will be number of patients with SAME, as compared between the 2 groups. Analgesia will be based on Numerical Analogue Scale for Pain 0-10 (appendix 3), and Post-operative nausea and vomiting will be based on Verbal Descriptive Scale 0-5 (appendix 3). These observations will be made at the end of 2 hrs or before (corresponding to the time of discharge from PACU), by the PACU nurse. |
| Secondary | Number of Patients With Severe Itching | At 2hrs or at the time of discharge from PACU | Severe itching measured as visual analog scale score \> 5 on a 0-10 Visual Analog Scale, where 0 = no itching, and 10 = worst itching imaginable |
| Secondary | Severe Sedation | At 2hrs or at the time of discharge from PACU | Ramsay Sedation Scale 0-6 |
| Secondary | Severe Respiratory Depression | At 2hrs or at the time of discharge from PACU | Presence of Respiratory Rate below 10 and/or Presence of Oxygen Saturation \<90 |
| Secondary | Patients Requesting Oral Analgesia in the Day Surgery Unit | At 2hrs or at the time of discharge from PACU | Use of rescue drug for pain |
| Secondary | Mean Dose of Analgesic Used | 5 hours post-admit to hospital | For a day surgery case, from the time of hospital admittance to discharge from hospital is an average 5 hours. |
| Secondary | Patient Satisfaction Score | At 5 hours post-admit to hospital | Patient satisfaction is measured on a 0-10 visual analogue scale, where 0=completely unsatisfied; 10=extremely satisfied |
| Secondary | Time to Discharge From PACU | At 2hrs or at the time of discharge from PACU | For a day surgery case, from the time out of operating room to discharge from PACU is an average 2 hours. |
| Secondary | Time to Discharge From Hospital | At 5 hours post-admit to hospital | For a day surgery case, from the time of hospital admittance to discharge from hospital is an average 5 hours. |
Source ClinicalTrials.gov
Outcomes9
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Our Combined Primary Outcome Will be Number of Patients With Same Analgesia Minimal Emesis, as Compared Between the 2 Groups. | At 2hrs or at the time of discharge from PACU | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Number of Patients With Severe Itching | At 2hrs or at the time of discharge from PACU | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Severe Sedation | At 2hrs or at the time of discharge from PACU | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Severe Respiratory Depression | At 2hrs or at the time of discharge from PACU | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Patients Requesting Oral Analgesia in the Day Surgery Unit | At 2hrs or at the time of discharge from PACU | Participants | COUNT_OF_PARTICIPANTS | |
| SECONDARY | Mean Dose of Analgesic Used | 5 hours post-admit to hospital | Equivalent morphine unit | MEAN | |
| SECONDARY | Patient Satisfaction Score | At 5 hours post-admit to hospital | score on a scale | MEAN | |
| SECONDARY | Time to Discharge From PACU | At 2hrs or at the time of discharge from PACU | Minutes | MEAN | |
| SECONDARY | Time to Discharge From Hospital | At 5 hours post-admit to hospital | Hours | MEAN |
Source ClinicalTrials.gov
Results by group18
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Our Combined Primary Outcome Will be Number of Patients With Same Analgesia Minimal Emesis, as Compared Between the 2 Groups. | Morphine | 172 | Participants | ||
| Our Combined Primary Outcome Will be Number of Patients With Same Analgesia Minimal Emesis, as Compared Between the 2 Groups. | Hydromorphone | 175 | Participants | ||
| Number of Patients With Severe Itching | Morphine | 2 | Participants | ||
| Number of Patients With Severe Itching | Hydromorphone | 5 | Participants | ||
| Severe Sedation | Morphine | 5 | Participants | ||
| Severe Sedation | Hydromorphone | 8 | Participants | ||
| Severe Respiratory Depression | Morphine | 11 | Participants | ||
| Severe Respiratory Depression | Hydromorphone | 10 | Participants | ||
| Patients Requesting Oral Analgesia in the Day Surgery Unit | Morphine | 128 | Participants | ||
| Patients Requesting Oral Analgesia in the Day Surgery Unit | Hydromorphone | 135 | Participants |
1 to 10 of 18Source ClinicalTrials.gov
See all 18 results by groupParticipant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Morphine | 199 | |
| Overall Study | STARTED | Hydromorphone | 203 | |
| Overall Study | COMPLETED | Morphine | 199 | |
| Overall Study | COMPLETED | Hydromorphone | 203 | |
| Overall Study | NOT COMPLETED | Morphine | 0 | |
| Overall Study | NOT COMPLETED | Hydromorphone | 0 |
Source ClinicalTrials.gov
Adverse events6
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| other | Severe itching | Skin and subcutaneous tissue disorders | Morphine | 2 | 199 | |
| other | Severe itching | Skin and subcutaneous tissue disorders | Hydromorphone | 5 | 202 | |
| other | Severe sedation | Nervous system disorders | Morphine | 5 | 199 | |
| other | Severe sedation | Nervous system disorders | Hydromorphone | 8 | 202 | |
| serious | Respiratory Depression | Respiratory, thoracic and mediastinal disorders | Morphine | 11 | 199 | |
| serious | Respiratory Depression | Respiratory, thoracic and mediastinal disorders | Hydromorphone | 10 | 202 |
Source ClinicalTrials.gov
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Morphine | 0 | 199 |
| Total, all-cause mortality | Hydromorphone | 0 | 202 |
| Total, other adverse events | Morphine | 7 | 199 |
| Total, other adverse events | Hydromorphone | 13 | 202 |
| Total, serious adverse events | Morphine | 11 | 199 |
| Total, serious adverse events | Hydromorphone | 10 | 202 |
Source ClinicalTrials.gov
Papers9
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons7
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Morphine vs Hydromorphone: Severe Respiratory Depression | Trial comparisons |
| Morphine vs Hydromorphone: Number of Patients With Severe Itching | Trial comparisons |
| Morphine vs Hydromorphone: Severe Sedation | Trial comparisons |
| Morphine vs Hydromorphone: Patients Requesting Oral Analgesia in the Day Surgery Unit | Trial comparisons |
| Morphine vs Hydromorphone: Our Combined Primary Outcome Will be Number of Patients With Same Analgesia Minimal Emesis, as Compared Between the 2 Groups. | Trial comparisons |
| Morphine vs Hydromorphone: deaths from any cause | Trial comparisons |
| Morphine vs Hydromorphone: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02223377
GET https://conductscience.org/api/trials/v1/NCT02223377/registered