Trial · NCT02243046

The Clinical Investigation of a Zinc Based Toothpaste in Reducing Plaque and Gingivitis

NCT02243046, Phase 2, Completed, Colgate Palmolive; results first posted 2016-05-04

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. The Clinical Investigation of a Zinc Based Toothpaste in Reducing Plaque and Gingivitis. Trials, record NCT02243046. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02243046

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: The Clinical Investigation of a Zinc Based Toothpaste in Reducing Plaque and Gingivitis
NCT number: NCT02243046
Status: Completed
Phases: Phase 2
Enrollment: 162 participants, actual
Lead sponsor: Colgate Palmolive
Conditions: Dental Plaque and Gingivitis
Interventions: Control toothpaste, Experimental toothpaste, Active Comparator
First posted: 2014-09-17
Last updated: 2019-02-25
Results first posted: 2016-05-04

Source ClinicalTrials.gov

Registered outcomes6

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Gingivitis Scores	Baseline	Gingivitis scale (Loe \& Silness Gingival Index) Units on a scale 0 to 3 (0 = no inflammation, 1 = Mild inflammation-slight change in color and little change in texture 2 = Moderate inflammation-moderate glazing, redness, edema and hypertrophy. Tendency to bleed upon probing. 3 = Severe inflammation-marked redness and hypertrophy. Tendency to spontaneous bleeding)
Primary	Gingivitis Scores	3 months (from Baseline)	Gingivitis scale (Loe \& Silness Gingival Index) Units on a scale 0 to 3 (0 = no inflammation, 1 = Mild inflammation-slight change in color and little change in texture 2 = Moderate inflammation-moderate glazing, redness, edema and hypertrophy. Tendency to bleed upon probing. 3 = Severe inflammation-marked redness and hypertrophy. Tendency to spontaneous bleeding)
Primary	Gingivitis Scores	6 months (from Baseline)	Gingivitis scale (Loe \& Silness Gingival Index) Units on a scale 0 to 3 (0 = no inflammation, 1 = Mild inflammation-slight change in color and little change in texture 2 = Moderate inflammation-moderate glazing, redness, edema and hypertrophy. Tendency to bleed upon probing. 3 = Severe inflammation-marked redness and hypertrophy. Tendency to spontaneous bleeding)
Primary	Dental Plaque Scores	Baseline	Dental Plaque (Quigley-Hein, Turesky Modification Index) Units on a scale 0 to 5 (0 = no plaque, 1 = separate flecks of plaque on the tooth, 2 = a thin continuous band of plaque, 3 = a band of plaque up to one-third of the tooth, 4 = plaque covering up to two thirds of the of the tooth, 5 = plaque covering two-thirds or more of the crown of the tooth)
Primary	Dental Plaque Scores	3 months (from Baseline)	Dental Plaque (Quigley-Hein, Turesky Modification Index) Units on a scale 0 to 5 (0 = no plaque, 1 = separate flecks of plaque on the tooth, 2 = a thin continuous band of plaque, 3 = a band of plaque up to one-third of the tooth, 4 = plaque covering up to two thirds of the of the tooth, 5 = plaque covering two-thirds or more of the crown of the tooth)
Primary	Dental Plaque Scores	6 months (from Baseline)	Dental Plaque (Quigley-Hein, Turesky Modification Index) Units on a scale 0 to 5 (0 = no plaque, 1 = separate flecks of plaque on the tooth, 2 = a thin continuous band of plaque, 3 = a band of plaque up to one-third of the tooth, 4 = plaque covering up to two thirds of the of the tooth, 5 = plaque covering two-thirds or more of the crown of the tooth)

Source ClinicalTrials.gov

Outcomes6

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Units	Measured as
PRIMARY	Gingivitis Scores	Baseline	units on a scale	MEAN
PRIMARY	Gingivitis Scores	3 months (from Baseline)	units on a scale	MEAN
PRIMARY	Gingivitis Scores	6 months (from Baseline)	units on a scale	MEAN
PRIMARY	Dental Plaque Scores	Baseline	units on a scale	MEAN
PRIMARY	Dental Plaque Scores	3 months (from Baseline)	units on a scale	MEAN
PRIMARY	Dental Plaque Scores	6 months (from Baseline)	units on a scale	MEAN

Source ClinicalTrials.gov

Results by group18

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Spread	Units
Gingivitis Scores	Control Toothpaste	1.48	Standard Deviation 0.23	units on a scale
Gingivitis Scores	Experimental Toothpaste	1.57	Standard Deviation 0.28	units on a scale
Gingivitis Scores	Active Comparator	1.49	Standard Deviation 0.20	units on a scale
Gingivitis Scores	Control Toothpaste	1.46	Standard Deviation 0.19	units on a scale
Gingivitis Scores	Experimental Toothpaste	1.33	Standard Deviation 0.23	units on a scale
Gingivitis Scores	Active Comparator	1.25	Standard Deviation 0.18	units on a scale
Gingivitis Scores	Control Toothpaste	1.44	Standard Deviation 0.20	units on a scale
Gingivitis Scores	Experimental Toothpaste	1.23	Standard Deviation 0.23	units on a scale
Gingivitis Scores	Active Comparator	1.19	Standard Deviation 0.17	units on a scale
Dental Plaque Scores	Control Toothpaste	2.91	Standard Deviation 0.24	units on a scale

1 to 10 of 18Source ClinicalTrials.gov

See all 18 results by group

Participant flow15

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	Control Toothpaste	55
Overall Study	STARTED	Experimental Toothpaste	54
Overall Study	STARTED	Active Comparator	53
Overall Study	3 Month	Control Toothpaste	54
Overall Study	3 Month	Experimental Toothpaste	53
Overall Study	3 Month	Active Comparator	51
Overall Study	6 Month	Control Toothpaste	54
Overall Study	6 Month	Experimental Toothpaste	53
Overall Study	6 Month	Active Comparator	49
Overall Study	COMPLETED	Control Toothpaste	54

1 to 10 of 15Source ClinicalTrials.gov

See all 15 participant flow

Adverse events0

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

None in this release.

Adverse event totals9

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Control Toothpaste
Total, all-cause mortality	Experimental Toothpaste
Total, all-cause mortality	Active Comparator
Total, other adverse events	Control Toothpaste	0	55
Total, other adverse events	Experimental Toothpaste	0	54
Total, other adverse events	Active Comparator	0	53
Total, serious adverse events	Control Toothpaste	0	55
Total, serious adverse events	Experimental Toothpaste	0	54
Total, serious adverse events	Active Comparator	0	53

Source ClinicalTrials.gov

Papers0

The papers the trial lists on ClinicalTrials.gov.

None in this release.

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons0

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

None in this release.

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT02243046

GET https://conductscience.org/api/trials/v1/NCT02243046/registered

API reference For AI assistants