Trial · NCT02243631
Effect of Probenecid on Synovial Fluid ATP Levels in CPPD
NCT02243631, Early phase 1, Completed, VA Office of Research and Development; results first posted 2022-07-26
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Effect of Probenecid on Synovial Fluid ATP Levels in CPPD. Trials, record NCT02243631. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02243631
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Effect of Probenecid on Synovial Fluid ATP Levels in CPPD
- NCT number
- NCT02243631
- Status
- Completed
- Phases
- Early phase 1
- Enrollment
- 8 participants, actual
- Lead sponsor
- VA Office of Research and Development
- Conditions
- Calcium Pyrophosphate Deposition Disease
- Interventions
- Probenecid
- First posted
- 2014-09-18
- Last updated
- 2022-07-26
- Results first posted
- 2022-07-26
Source ClinicalTrials.gov
Registered outcomes1
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | ATP Levels in Synovial Fluid | 5 days | The investigators will measure levels of ATP in synovial fluid from patients with CPPD before and after treatment with probenecid compared to patients receiving no therapy. ATP levels are measured with a standard bioluminescent assay. |
Source ClinicalTrials.gov
Outcomes1
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | ATP Levels in Synovial Fluid | 5 days | Two subjects ( one in probenecid and one in no intervention group) had no measurable ATP on the second aspirate, and one subject in the no intervention group did not have any synovial fluid on the second visit. | nanomoles/ml | MEAN |
Source ClinicalTrials.gov
Results by group2
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| ATP Levels in Synovial Fluid | Probenecid | 4.4 | Standard Deviation 2.5 | nanomoles/ml | |
| ATP Levels in Synovial Fluid | no Intervention | 31.4 | Standard Deviation 56.6 | nanomoles/ml |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Probenecid | 3 | |
| Overall Study | STARTED | No Intervention | 5 | |
| Overall Study | COMPLETED | Probenecid | 3 | |
| Overall Study | COMPLETED | No Intervention | 4 | |
| Overall Study | NOT COMPLETED | Probenecid | 0 | |
| Overall Study | NOT COMPLETED | No Intervention | 1 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Probenecid | 0 | 3 |
| Total, all-cause mortality | No Intervention | 0 | 5 |
| Total, other adverse events | Probenecid | 0 | 3 |
| Total, other adverse events | No Intervention | 0 | 5 |
| Total, serious adverse events | Probenecid | 0 | 3 |
| Total, serious adverse events | No Intervention | 0 | 5 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons2
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Probenecid vs No Intervention: deaths from any cause | Trial comparisons |
| Probenecid vs No Intervention: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02243631
GET https://conductscience.org/api/trials/v1/NCT02243631/registered