Trial · NCT02244619
PO vs. IV Acetaminophen Given Perioperatively for 24 hr Post-op Pain Control Following Total Hip or Knee Replacement
NCT02244619, Phase 4, Completed, Kettering Health Network; results first posted 2017-07-24
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. PO vs. IV Acetaminophen Given Perioperatively for 24 hr Post-op Pain Control Following Total Hip or Knee Replacement. Trials, record NCT02244619. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02244619
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- PO vs. IV Acetaminophen Given Perioperatively for 24 hr Post-op Pain Control Following Total Hip or Knee Replacement
- NCT number
- NCT02244619
- Status
- Completed
- Phases
- Phase 4
- Enrollment
- 515 participants, actual
- Lead sponsor
- Kettering Health Network
- Conditions
- Post-op Pain
- Interventions
- Oral acetaminophen, IV acetaminophen
- First posted
- 2014-09-19
- Last updated
- 2017-07-24
- Results first posted
- 2017-07-24
- Limitations and caveats
- Single hospital, limited to two types of surgical patient. No standard protocol for assessing pain. Oral acetaminophen administered earlier than IV per hospital protocol.
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Total Post-operative Use of Opioids | During post-op period up to 24 hrs after surgery | Post-operative use of opioids, measured in morphine milligram equivalent (MME) units |
| Secondary | Patient-rated Pain in the Post-operative Period | Standard-of-care post-op assessment intervals during post-op period up to 24 hrs after surgery | Patient-rated pain in the post-operative period was collected using a 10-point visual analog scale (VAS). A score of 0 indicates no pain; higher scores indicate greater pain. Minimum score for each VAS measurement is 0; Maximum score for each VAS measurement is 10. VAS scores were averaged for each patient. |
| Other | Post-operative Nausea and Vomiting | During post-op period up to 24 hrs after surgery | |
| Other | Time to First Ambulation - 10 Feet | During post-op period up to 24 hours after surgery | |
| Other | Time to First Rescue Opioid (PRN Order) | During post-op period up to 24 hrs after surgery |
Source ClinicalTrials.gov
Outcomes7
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Total Post-operative Use of Opioids | During post-op period up to 24 hrs after surgery | Morphine milligram equivalents (MME) | MEDIAN | |
| SECONDARY | Patient-rated Pain in the Post-operative Period | Standard-of-care post-op assessment intervals during post-op period up to 24 hrs after surgery | Visual analog pain scale (0-10) | MEDIAN | |
| OTHER_PRE_SPECIFIED | Post-operative Nausea and Vomiting | During post-op period up to 24 hrs after surgery | Participants | COUNT_OF_PARTICIPANTS | |
| OTHER_PRE_SPECIFIED | Time to First Ambulation - 10 Feet | During post-op period up to 24 hours after surgery | Hours | MEDIAN | |
| OTHER_PRE_SPECIFIED | Time to First Rescue Opioid (PRN Order) | During post-op period up to 24 hrs after surgery | Minutes | MEDIAN | |
| POST_HOC | Post-Anesthesia Care Unit (PACU) Length of Stay, Hours | PACU admission time until PACU discharge time | Hours | MEDIAN | |
| POST_HOC | Hospital Length of Stay (LOS) | Pre-op admission to hospital discharge | Hours | MEDIAN |
Source ClinicalTrials.gov
Results by group16
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Total Post-operative Use of Opioids | Oral Acetaminophen | 21.7 | Inter-Quartile Range 12.5 to 33.6 | Morphine milligram equivalents (MME) | |
| Total Post-operative Use of Opioids | IV Acetaminophen | 21.7 | Inter-Quartile Range 11.3 to 34.4 | Morphine milligram equivalents (MME) | |
| Patient-rated Pain in the Post-operative Period | Oral Acetaminophen | 3.6 | Inter-Quartile Range 2.4 to 5.0 | Visual analog pain scale (0-10) | |
| Patient-rated Pain in the Post-operative Period | IV Acetaminophen | 3.4 | Inter-Quartile Range 2.1 to 4.8 | Visual analog pain scale (0-10) | |
| Post-operative Nausea and Vomiting | Oral Acetaminophen | Nausea | 51 | Participants | |
| Post-operative Nausea and Vomiting | IV Acetaminophen | Nausea | 53 | Participants | |
| Post-operative Nausea and Vomiting | Oral Acetaminophen | Vomiting | 19 | Participants | |
| Post-operative Nausea and Vomiting | IV Acetaminophen | Vomiting | 17 | Participants | |
| Time to First Ambulation - 10 Feet | Oral Acetaminophen | 18.5 | Inter-Quartile Range 13.8 to 21.3 | Hours | |
| Time to First Ambulation - 10 Feet | IV Acetaminophen | 18.8 | Inter-Quartile Range 15.1 to 21.0 | Hours |
1 to 10 of 16Source ClinicalTrials.gov
See all 16 results by groupParticipant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Oral Acetaminophen | 249 | |
| Overall Study | STARTED | IV Acetaminophen | 266 | |
| Overall Study | COMPLETED | Oral Acetaminophen | 241 | |
| Overall Study | COMPLETED | IV Acetaminophen | 245 | |
| Overall Study | NOT COMPLETED | Oral Acetaminophen | 8 | |
| Overall Study | NOT COMPLETED | IV Acetaminophen | 21 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Oral Acetaminophen | 0 | 241 |
| Total, all-cause mortality | IV Acetaminophen | 0 | 245 |
| Total, other adverse events | Oral Acetaminophen | 0 | 241 |
| Total, other adverse events | IV Acetaminophen | 0 | 245 |
| Total, serious adverse events | Oral Acetaminophen | 0 | 241 |
| Total, serious adverse events | IV Acetaminophen | 0 | 245 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons2
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Oral Acetaminophen vs IV Acetaminophen: deaths from any cause | Trial comparisons |
| Oral Acetaminophen vs IV Acetaminophen: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02244619
GET https://conductscience.org/api/trials/v1/NCT02244619/registered