Trial · NCT02265874
Nicotine Treatment for Pulmonary Sarcoidosis: A Clinical Trial Pilot Study
NCT02265874, Phase 1, Phase 2, Completed, Ohio State University; results first posted 2025-04-24
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Nicotine Treatment for Pulmonary Sarcoidosis: A Clinical Trial Pilot Study. Trials, record NCT02265874. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02265874
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Nicotine Treatment for Pulmonary Sarcoidosis: A Clinical Trial Pilot Study
- NCT number
- NCT02265874
- Status
- Completed
- Phases
- Phase 1, Phase 2
- Enrollment
- 50 participants, actual
- Lead sponsor
- Ohio State University
- Conditions
- Sarcoidosis
- Interventions
- Habitrol, Placebo to Habitrol
- First posted
- 2014-10-16
- Last updated
- 2025-04-24
- Results first posted
- 2025-04-24
Source ClinicalTrials.gov
Registered outcomes2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Forced Vital Capacity (FVC) | 28 weeks | changes in forced vital capacity (FVC) measured by pulmonary function testing (breathing tests) measured in liters |
| Secondary | Changes Detected by Computed Tomography (CT) of Lungs | 28 weeks | CT lung scans are analyzed by a computer program: Briefly, lung architecture, manifest as pixelated Houndsfield units, is assessed for regional mismatches (texture), wherein linear conformation of pixels are removed (equating with airways, blood or lymphatic vessels) and the mismatched pixels are quantified (i.e., Lung Texture Score; LTS) and are reflective of lung anatomy, including lung nodules, interstitial fibrosis or alveolar ground glass (i.e., pulmonary sarcoidosis manifestations). LTS is represented by arbitrary units, and are reported to range from 25 - 70; 25-40 being within the normal range (i.e., normal lung anatomy; and values in the 40 - 70 range are associated lung parenchymal disease (PMID: 22628482). |
Source ClinicalTrials.gov
Outcomes2
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Forced Vital Capacity (FVC) | 28 weeks | Change in FVC from baseline to week 28 (study completion) in Habitrol treatment group compared to Placebo treatment group. | liters | MEAN |
| SECONDARY | Changes Detected by Computed Tomography (CT) of Lungs | 28 weeks | Change in lung texture score from baseline to study completion in the Habitrol treatment group compared to the Placebo group. | score on a scale | MEAN |
Source ClinicalTrials.gov
Results by group4
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Forced Vital Capacity (FVC) | Treatment | 0.07 | Standard Error 0.22 | liters | |
| Forced Vital Capacity (FVC) | Control | -0.07 | Standard Error 0.04 | liters | |
| Changes Detected by Computed Tomography (CT) of Lungs | Treatment | -1.0 | Standard Deviation 3.5 | score on a scale | |
| Changes Detected by Computed Tomography (CT) of Lungs | Control | 2.5 | Standard Deviation 3.5 | score on a scale |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Habitrol | 24 | |
| Overall Study | STARTED | Placebo | 26 | |
| Overall Study | COMPLETED | Habitrol | 20 | |
| Overall Study | COMPLETED | Placebo | 20 | |
| Overall Study | NOT COMPLETED | Habitrol | 4 | |
| Overall Study | NOT COMPLETED | Placebo | 6 |
Source ClinicalTrials.gov
Adverse events4
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events |
|---|---|---|---|---|---|---|
| other | Nausea | Gastrointestinal disorders | Treatment | 6 | 24 | 6 |
| other | Nausea | Gastrointestinal disorders | Control | 2 | 26 | 2 |
| other | Headache | Nervous system disorders | Treatment | 6 | 24 | 6 |
| other | Headache | Nervous system disorders | Control | 2 | 26 | 2 |
Source ClinicalTrials.gov
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Treatment | 0 | 24 |
| Total, all-cause mortality | Control | 0 | 26 |
| Total, other adverse events | Treatment | 6 | 24 |
| Total, other adverse events | Control | 2 | 26 |
| Total, serious adverse events | Treatment | 0 | 24 |
| Total, serious adverse events | Control | 0 | 26 |
Source ClinicalTrials.gov
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons2
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Treatment vs Control: deaths from any cause | Trial comparisons |
| Treatment vs Control: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02265874
GET https://conductscience.org/api/trials/v1/NCT02265874/registered