Efficacy of Vortioxetine on Cognitive Dysfunction in Patients With Partial or Full Remission of Major Depressive Disorder
NCT02279953, Phase 3, Completed, H. Lundbeck A/S
Trial 11
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Efficacy of Vortioxetine on Cognitive Dysfunction in Patients With Partial or Full Remission of Major Depressive Disorder | ClinicalTrials.gov |
| NCT number | NCT02279953 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Phase 3 | ClinicalTrials.gov |
| Enrollment | 151 participants, actual | ClinicalTrials.gov |
| Lead sponsor | H. Lundbeck A/S | ClinicalTrials.gov |
| Conditions | Major Depressive Disorder | ClinicalTrials.gov |
| Interventions | Vortioxetine 10-20 mg, Placebo, SSRI | ClinicalTrials.gov |
| First posted | 2014-10-31 | ClinicalTrials.gov |
| Last updated | 2017-05-24 | ClinicalTrials.gov |
| Other registries' IDs | eudract:2014-000229-19 | ClinicalTrials.gov |
Registered outcomes 15
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Change in Digit Symbol Substitution Test (DSST): number of correct symbols | Baseline to Week 8 | ClinicalTrials.gov | |
| Secondary | Change in Rey Auditory Verbal Learning Test (RAVLT) score: memory (delayed recall) and learning [acquisition]) | Baseline to Week 8 | ClinicalTrials.gov | |
| Secondary | Change in Trail Making Test (TMT) score: TMT-A; speed of processing | Baseline to Week 8 | ClinicalTrials.gov | |
| Secondary | Change in TMT score: TMT-B; executive functioning | Baseline to Week 8 | ClinicalTrials.gov | |
| Secondary | Change in reaction time score: Choice Reaction Time (CRT); attention | Baseline to Week 8 | ClinicalTrials.gov | |
| Secondary | Change in reaction time score: Simple Reaction Time (SRT); psychomotor speed | Baseline to Week 8 | ClinicalTrials.gov | |
| Secondary | Change in Stroop Colour Naming Test (STROOP): incongruent score; executive functioning | Baseline to Week 8 | ClinicalTrials.gov | |
| Secondary | Change in STROOP: congruent score; speed of processing | Baseline to Week 8 | ClinicalTrials.gov | |
| Secondary | Change in Perceived Deficits Questionnaire - Depression (PDQ-D) total score | Baseline to Week 8 | ClinicalTrials.gov | |
| Secondary | Change in Hamilton Depression Rating Scale-17 (HAMD-17) total score | Baseline to Week 8 | ClinicalTrials.gov | |
| Secondary | Change in Clinical Global Impression - Severity of Illness (CGI-S) | Baseline to Week 8 | ClinicalTrials.gov | |
| Secondary | Clinical Global Impression - Global Improvement (CGI-I) score | Week 8 | ClinicalTrials.gov | |
| Secondary | Change in University of San Diego Performance-based Skills Assessment - Brief (UPSA-B) total score | Baseline to Week 8 | ClinicalTrials.gov | |
| Secondary | Number of adverse events | Baseline to Week 12 | ClinicalTrials.gov | |
| Secondary | Columbia Suicide Severity Rating Scale (C-SSRS) categorisation based on Columbia Classification Algorithm of Suicide Assessment (C-CASA) definitions (1, 2, 3, 4 and 7) | Baseline to Week 8 | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 7
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Symbol Coding | Primary outcome | ConductCognition |
| Choice Reaction Time | Secondary outcome | ConductCognition |
| Simple Reaction Time | Secondary outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Trail Making Test A | Secondary outcome | ConductCognition |
| Trail Making Test B | Secondary outcome | ConductCognition |
| Verbal Learning | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)