Registered outcomes11

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

1 to 11 of 11

List	Outcome	Time frame
Primary	Safety, as assessed by frequency and severity of adverse events (AEs), and changes in vital signs, 12-lead electrocardiograms (ECGs), and laboratory assessments as compared to baseline	30 - 118 days
Secondary	Blood and plasma area under the concentration time curve (AUC) of GBT440	30 - 118 days
Secondary	Blood and plasma maximum concentration (Cmax) of GBT440	30 - 118 days
Secondary	Blood and plasma time to maximum concentration (Tmax) of GBT440	30 - 118 days
Secondary	Percentage of hemoglobin occupied or modified by GBT440	30 days
Secondary	Change from baseline in heart rate and pulse oximetry following exercise testing in healthy volunteers	30 days
Other	Percentage of sickled cells under ex vivo conditions	30 - 90 days
Other	Effect of GBT440 on hemolysis as measured by LDH, direct bilirubin, hemoglobin, and reticulocyte count	30 - 118 days
Other	Change from baseline in pain as measured by visual analog scale	30 days
Other	Change from baseline in fatigue as measured by questionnaire	30 - 118 days
Other	Exercise capacity as measured by 6-minute walk test	30 - 90 days

Source ClinicalTrials.govtrials-2026-11-12-0.5.0

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Twenty rows a page, as JSON. No key.

GET https://conductscience.org/api/trials/v1/NCT02285088/registered