Trial · NCT02295280
A Cost Effective Treatment for Headache in Pregnancy When Acetaminophen Alone is Ineffective.
NCT02295280, Not applicable, Completed, St. Louis University; results first posted 2018-04-02
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Cost Effective Treatment for Headache in Pregnancy When Acetaminophen Alone is Ineffective. Trials, record NCT02295280. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02295280
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- A Cost Effective Treatment for Headache in Pregnancy When Acetaminophen Alone is Ineffective.
- NCT number
- NCT02295280
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 70 participants, actual
- Lead sponsor
- St. Louis University
- Conditions
- Headache
- Interventions
- Metoclopramide, Diphenhydramine, Codeine
- First posted
- 2014-11-20
- Last updated
- 2018-04-02
- Results first posted
- 2018-04-02
- Limitations and caveats
One of the limitations of our study is that codeine was used as standard for comparison to the MAD regimen. This was due to poor patient enrollment with an earlier study design comparing MAD to placebo.
Source ClinicalTrials.gov
Registered outcomes1
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Number of Participants With Adequate Relief of Headache as a Measure of Efficacy | Primary outcome was six hours post administration | Number of participants with reduction in pain scores six hours post administration by at least 2 on the pain score scale. |
Source ClinicalTrials.gov
Outcomes1
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Number of Participants With Adequate Relief of Headache as a Measure of Efficacy | Primary outcome was six hours post administration | Number in each arm with data at 6 hours who received either metoclopramide and diphenhydramine IV or codeine. | Participants | COUNT_OF_PARTICIPANTS |
Source ClinicalTrials.gov
Results by group2
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Number of Participants With Adequate Relief of Headache as a Measure of Efficacy | Metoclopramide IV & Diphenhydramine IV | 34 | Participants | ||
| Number of Participants With Adequate Relief of Headache as a Measure of Efficacy | Codeine | 32 | Participants |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Metoclopramide IV & Diphenhydramine IV | 35 | |
| Overall Study | STARTED | Codeine | 35 | |
| Overall Study | COMPLETED | Metoclopramide IV & Diphenhydramine IV | 35 | |
| Overall Study | COMPLETED | Codeine | 34 | |
| Overall Study | NOT COMPLETED | Metoclopramide IV & Diphenhydramine IV | 0 | |
| Overall Study | NOT COMPLETED | Codeine | 1 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Metoclopramide & Diphenhydramine | 0 | 35 |
| Total, all-cause mortality | Codeine | 0 | 35 |
| Total, other adverse events | Metoclopramide & Diphenhydramine | 0 | 35 |
| Total, other adverse events | Codeine | 0 | 35 |
| Total, serious adverse events | Metoclopramide & Diphenhydramine | 0 | 35 |
| Total, serious adverse events | Codeine | 0 | 35 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons3
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|---|
| Metoclopramide IV & Diphenhydramine IV vs Codeine: Number of Participants With Adequate Relief of Headache as a Measure of Efficacy | Trial comparisons |
| Metoclopramide & Diphenhydramine vs Codeine: deaths from any cause | Trial comparisons |
| Metoclopramide & Diphenhydramine vs Codeine: serious adverse events | Trial comparisons |
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02295280
GET https://conductscience.org/api/trials/v1/NCT02295280/registered