Trial · NCT02307565

Blood Pressure, Cerebral Blood Flow and Cognition in Spinal Cord Injury

NCT02307565, Phase 3, Completed, James J. Peters Veterans Affairs Medical Center; results first posted 2025-02-21

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Blood Pressure, Cerebral Blood Flow and Cognition in Spinal Cord Injury. Trials, record NCT02307565. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02307565

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Blood Pressure, Cerebral Blood Flow and Cognition in Spinal Cord Injury
NCT number: NCT02307565
Status: Completed
Phases: Phase 3
Enrollment: 19 participants, actual
Lead sponsor: James J. Peters Veterans Affairs Medical Center
Conditions: Spinal Cord Injury
Interventions: Midodrine, Placebo
First posted: 2014-12-04
Last updated: 2025-02-21
Results first posted: 2025-02-21

Source ClinicalTrials.gov

Registered outcomes4

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Systolic Blood Pressure	30 days	Seated systolic blood pressure following midodrine administration compared to placebo.
Secondary	Cerebral Blood Flow	30 days	Middle cerebral artery blood flow velocity following midodrine administration compared to placebo.
Secondary	Hopkins Verbal Learning Test	30 days	Memory score on the Hopkins Verbal Learning Test following midodrine administration compared to placebo. Higher score is better, range from 0 to 36.
Secondary	Number of Hypertensive Events	30 days	Number of daily systolic blood pressure recordings above 140 mmHg following midodrine administration compared to placebo.

Source ClinicalTrials.gov

Outcomes4

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Units	Measured as
PRIMARY	Systolic Blood Pressure	30 days	mmHg	MEAN
SECONDARY	Cerebral Blood Flow	30 days	cm/sec	MEAN
SECONDARY	Hopkins Verbal Learning Test	30 days	score on a scale	MEAN
SECONDARY	Number of Hypertensive Events	30 days	blood pressure recordings	NUMBER

Source ClinicalTrials.gov

Results by group8

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Spread	Units
Systolic Blood Pressure	Midodrine	116.3	Standard Deviation 22.7	mmHg
Systolic Blood Pressure	Placebo	98.0	Standard Deviation 23.3	mmHg
Cerebral Blood Flow	Midodrine	45.08	Standard Deviation 12.87	cm/sec
Cerebral Blood Flow	Placebo	43.97	Standard Deviation 16.70	cm/sec
Hopkins Verbal Learning Test	Midodrine	-3.56	Standard Deviation 4.16	score on a scale
Hopkins Verbal Learning Test	Placebo	-2.27	Standard Deviation 6.47	score on a scale
Number of Hypertensive Events	Midodrine	112		blood pressure recordings
Number of Hypertensive Events	Placebo	50		blood pressure recordings

Source ClinicalTrials.gov

Participant flow6

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	Midodrine/Placebo	8
Overall Study	STARTED	Placebo/Midodrine	11
Overall Study	COMPLETED	Midodrine/Placebo	3
Overall Study	COMPLETED	Placebo/Midodrine	7
Overall Study	NOT COMPLETED	Midodrine/Placebo	5
Overall Study	NOT COMPLETED	Placebo/Midodrine	4

Source ClinicalTrials.gov

Adverse events6

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

Type	Event	Organ system	Group	Affected	At risk	Events
other	Hypertensive response	Vascular disorders	Midodrine	3	19	3
other	Hypertensive response	Vascular disorders	Placebo	0	19	0
other	UTI	Renal and urinary disorders	Midodrine	1	19	1
other	UTI	Renal and urinary disorders	Placebo		19
other	Constipation	Renal and urinary disorders	Midodrine	1	19	1
other	Constipation	Renal and urinary disorders	Placebo		19

Source ClinicalTrials.gov

Adverse event totals6

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Midodrine	0	19
Total, all-cause mortality	Placebo	0	19
Total, other adverse events	Midodrine	5	19
Total, other adverse events	Placebo	0	19
Total, serious adverse events	Midodrine	0	19
Total, serious adverse events	Placebo	0	19

Source ClinicalTrials.gov

Papers2

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as	Source
32203065	DERIVED	PubMed
33177997	DERIVED	PubMed

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons2

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

Comparison	Source
Midodrine vs Placebo: deaths from any cause	Trial comparisons
Midodrine vs Placebo: serious adverse events	Trial comparisons

Tests1

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

Test	Named as
Verbal Learning	Secondary outcome

Source ConductCognition

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT02307565

GET https://conductscience.org/api/trials/v1/NCT02307565/registered

API reference For AI assistants