Trial · NCT02308293
The Role of Endogenous Lactate in Brain Preservation and Counterregulatory Defenses Against Hypoglycemia
NCT02308293, Not applicable, Completed, Radboud University Medical Center
3 sourcestrials-2026-11-12-0.4.0
Cite this record
ConductScience Library. The Role of Endogenous Lactate in Brain Preservation and Counterregulatory Defenses Against Hypoglycemia. Trials, record NCT02308293. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02308293
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- The Role of Endogenous Lactate in Brain Preservation and Counterregulatory Defenses Against Hypoglycemia
- NCT number
- NCT02308293
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 30 participants, actual
- Lead sponsor
- Radboud University Medical Center
- Conditions
- Type 1 Diabetes Mellitus, Hypoglycemia Unawareness
- Interventions
- High intensity exercise, Lay down comfortably
- First posted
- 2014-12-04
- Last updated
- 2016-11-25
Source ClinicalTrials.gov
Registered outcomes10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Plasma level of adrenaline in response to hypoglycemia (Adrenaline, measured in arterial plasma) | during 60 m of hypoglycemia | |
| Secondary | Plasma levels of other counter-regulatory hormones (Levels of counter-regulatory hormones measured in arterial plasma) | During 60 min hypoglycemia | Levels of counter-regulatory hormones measured in arterial plasma |
| Secondary | Glucose infusion rate (Amount of glucose 20% necessary to maintain plasma glucose at steady state values) | During 60 min hypoglycemia | Amount of glucose 20% necessary to maintain plasma glucose at steady state values |
| Secondary | Plasma lactate levels (Lactate levels measured in arterial plasma) | During 60 min hypoglycemia | Lactate levels measured in arterial plasma |
| Secondary | Cognitive functioning, as measured by cognitive tests | During 60 min hypoglycemia | Cognitive test will be: Dutch State Trait Anxiety Inventory, Digit Span, Stroop color word test, word fluency test, trail making test and Pasat |
| Secondary | Plasma levels of inflammatory markers (levels of cytokines) | During 60 min hypoglycemia | levels of cytokines |
| Secondary | Brain perfusion measured with ASL-MRI | During 60 min hypoglycemia | Brain perfusion measured with ASL-MRI |
| Secondary | Brain lactate accumulation measured with 1H-MRS | During 60 min of hypoglycemia | Brain lactate levels measured with 1H-MRS |
| Other | Plasma glucose concentration | During 60 min hypoglycemia | Plasma glucose concentration, necessary to adjust glucose infusion rate |
| Other | Plasma insulin concentration (Insulin levels, measured in arterial plasma) | During 60 min hypoglycemia | Insulin levels, measured in arterial plasma |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers8
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests5
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Digit Span Test | Secondary outcome | ConductCognition |
| Paced Visual Serial Addition Test | Secondary outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Trail Making Test A | Secondary outcome | ConductCognition |
| Trail Making Test B | Secondary outcome | ConductCognition |
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02308293
GET https://conductscience.org/api/trials/v1/NCT02308293/registered