Trial · NCT02315443
Field Randomization of Nerinetide (NA-1) Therapy in Early Responders
NCT02315443, Phase 3, Completed, NoNO Inc.
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Field Randomization of Nerinetide (NA-1) Therapy in Early Responders. Trials, record NCT02315443. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02315443
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Field Randomization of Nerinetide (NA-1) Therapy in Early Responders
- NCT number
- NCT02315443
- Status
- Completed
- Phases
- Phase 3
- Enrollment
- 532 participants, actual
- Lead sponsor
- NoNO Inc.
- Conditions
- Acute Cerebral Ischemia
- Interventions
- Nerinetide (NA-1), Placebo
- First posted
- 2014-12-11
- Last updated
- 2023-05-12
Source ClinicalTrials.gov
Registered outcomes6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Modified Rankin Scale (mRS) scale | 90 days | The percentage of responders, using a sliding dichotomy on the mRS |
| Secondary | mRS shift analysis | 90 Days or the last rating | Shift to reduced functional dependence analyzed across the whole distribution of scores on the mRS |
| Secondary | Mortality rate | 90 Days | A reduction in mortality as defined by event rate (proportion, expressed as a percentage) |
| Secondary | Worsening of stroke rate | 90 Days | A reduction in proportion of participants with worsening of stroke. Worsening of stroke is defined as progression, or hemorrhagic transformation, of the index stroke as documented in the study CRF that (i) is deemed life-threatening and/or (ii) results in increased disability as gauged by a ≥4 point increase from lowest NIHSS during hospitalization and/or (iii) results in death. |
| Secondary | National Institutes of Health Stroke Scale (NIHSS) | 90 Days or the last rating | Proportion of subjects with good neurological outcome, as defined by a score of 0-1 on the NIHSS |
| Secondary | Barthel Index | 90 Days or the last rating | Proportion of subjects with functional independence in activities of daily living, as defined by a score of ≥ 95 on the Barthel Index |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02315443
GET https://conductscience.org/api/trials/v1/NCT02315443/registered