Trial · NCT02371759

Lidocaine + Clonidine for Intraoral Anesthesia in Patients With Diabetes Mellitus Type 2

NCT02371759, Phase 3, Completed, University of Belgrade; results first posted 2017-05-03

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. Lidocaine + Clonidine for Intraoral Anesthesia in Patients With Diabetes Mellitus Type 2. Trials, record NCT02371759. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02371759

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: Lidocaine + Clonidine for Intraoral Anesthesia in Patients With Diabetes Mellitus Type 2
NCT number: NCT02371759
Status: Completed
Phases: Phase 3
Enrollment: 256 participants, actual
Lead sponsor: University of Belgrade
Conditions: Diabetes Mellitus, Local Anesthesia
Interventions: L+C maxillary anesthesia, L+C mandibular anesthesia, L+E maxillary anesthesia, L+E mandibular anesthesia
First posted: 2015-02-26
Last updated: 2017-05-03
Results first posted: 2017-05-03

Source ClinicalTrials.gov

Registered outcomes25

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Duration of Intraoral Local Anesthesia	Up to 6 hours after local anesthesia injection	Time until cessation in soft tissue numbness
Primary	Intensity of Intraoral Local Anesthesia	Up to 10 minutes after local anesthesia injection	Number of participants who reported values \> 0 after pin-prick testing, using Visual Analogue Scale (VAS) and Numerical Rating Scale (NRS). VAS is represented by line 100 mm long, with one end marked with 0 and words "no pain" , while the other end is marked with 100 and words "the worst pain imanginable". VRS scale is represented by line 100 mm long, marked with numbers from 0 to 10, where 0 corresponds to "no pain", and 10 corresponds to "the worst pain imaginable". For both scales, higher scores represent worse outcomes.
Primary	Baseline Systolic Blood Pressure	Baseline, 0 minutes
Primary	Systolic Blood Pressure at 10 Minutes	10th minute	Systolic blood pressure values 5 minutes after local anesthesia injection
Primary	Systolic Blood Pressure at 15 Minutes	15th minute	Systolic blood pressure values 10 minutes after local anesthesia injection
Primary	Systolic Blood Pressure at 20 Minutes	20th minute	Systolic blood pressure values 15 minutes after local anesthesia injection
Primary	Systolic Blood Pressure at 35 Minutes	35th minute	Systolic blood pressure values 30 minutes after local anesthesia injection
Primary	Baseline Diastolic Blood Pressure	baseline, 0 minutes
Primary	Diastolic Blood Pressure at 10 Minutes	10th minute	Diastolic blood pressure values 5 minutes after local anesthesia injection
Primary	Diastolic Blood Pressure at 15 Minutes	15th minute	Diastolic blood pressure values 10 minutes after local anesthesia injection

1 to 10 of 25Source ClinicalTrials.gov

See all 25 registered outcomes

Outcomes25

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

Type	Outcome	Time frame	Units	Measured as
PRIMARY	Duration of Intraoral Local Anesthesia	Up to 6 hours after local anesthesia injection	minutes	MEAN
PRIMARY	Intensity of Intraoral Local Anesthesia	Up to 10 minutes after local anesthesia injection	Participants	COUNT_OF_PARTICIPANTS
PRIMARY	Baseline Systolic Blood Pressure	Baseline, 0 minutes	milimeters of Hg	MEAN
PRIMARY	Systolic Blood Pressure at 10 Minutes	10th minute	milimeters of Hg	MEAN
PRIMARY	Systolic Blood Pressure at 15 Minutes	15th minute	milimeters of Hg	MEAN
PRIMARY	Systolic Blood Pressure at 20 Minutes	20th minute	milimeters of Hg	MEAN
PRIMARY	Systolic Blood Pressure at 35 Minutes	35th minute	milimeters of Hg	MEAN
PRIMARY	Baseline Diastolic Blood Pressure	baseline, 0 minutes	milimeters of Hg	MEAN
PRIMARY	Diastolic Blood Pressure at 10 Minutes	10th minute	milimeters of Hg	MEAN
PRIMARY	Diastolic Blood Pressure at 15 Minutes	15th minute	milimeters of Hg	MEAN

1 to 10 of 25Source ClinicalTrials.gov

See all 25 outcomes

Results by group200

Each measurement the trial posted, group by group, in the words and numbers it posted.

Outcome	Group	Value	Spread	Units
Duration of Intraoral Local Anesthesia	Diabetics: L+C Maxillary Anesthesia	132.48	Standard Deviation 91.86	minutes
Duration of Intraoral Local Anesthesia	Diabetics: L+C Mandibular Anesthesia	173.27	Standard Deviation 70.44	minutes
Duration of Intraoral Local Anesthesia	Diabetics: L+E Maxillary Anesthesia	182.09	Standard Deviation 57.86	minutes
Duration of Intraoral Local Anesthesia	Diabetics: L+E Mandibular Anesthesia	195.35	Standard Deviation 68.99	minutes
Duration of Intraoral Local Anesthesia	Healthy: L+C Maxillary Anesthesia	108.82	Standard Deviation 27.76	minutes
Duration of Intraoral Local Anesthesia	Healthy: L+C Mandibular Anesthesia	155.59	Standard Deviation 60.75	minutes
Duration of Intraoral Local Anesthesia	Healthy: L+E Maxillary Anesthesia	114.74	Standard Deviation 39.72	minutes
Duration of Intraoral Local Anesthesia	Healthy: L+E Mandibular Anesthesia	172.91	Standard Deviation 68.93	minutes
Intensity of Intraoral Local Anesthesia	Diabetics: L+C Maxillary Anesthesia	2		Participants
Intensity of Intraoral Local Anesthesia	Diabetics: L+C Mandibular Anesthesia	2		Participants

1 to 10 of 200Source ClinicalTrials.gov

See all 200 results by group

Participant flow24

How many started, completed or left each group, period by period.

Period	Milestone	Group	Participants
Overall Study	STARTED	Diabetics: L+C Maxillary Anesthesia	32
Overall Study	STARTED	Diabetics: L+C Mandibular Anesthesia	31
Overall Study	STARTED	Diabetics: L+E Maxillary Anesthesia	33
Overall Study	STARTED	Diabetics: L+E Mandibular Anesthesia	31
Overall Study	STARTED	Healthy: L+C Maxillary Anesthesia	27
Overall Study	STARTED	Healthy: L+C Mandibular Anesthesia	26
Overall Study	STARTED	Healthy: L+E Maxillary Anesthesia	25
Overall Study	STARTED	Healthy: L+E Mandibular Anesthesia	28
Overall Study	COMPLETED	Diabetics: L+C Maxillary Anesthesia	29
Overall Study	COMPLETED	Diabetics: L+C Mandibular Anesthesia	30

1 to 10 of 24Source ClinicalTrials.gov

See all 24 participant flow

Adverse events0

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

None in this release.

Adverse event totals24

The totals the trial posted for each group.

Total	Group	Affected	At risk
Total, all-cause mortality	Diabetics: L+C Maxillary Anesthesia
Total, all-cause mortality	Diabetics: L+C Mandibular Anesthesia
Total, all-cause mortality	Diabetics: L+E Maxillary Anesthesia
Total, all-cause mortality	Diabetics: L+E Mandibular Anesthesia
Total, all-cause mortality	Healthy: L+C Maxillary Anesthesia
Total, all-cause mortality	Healthy: L+C Mandibular Anesthesia
Total, all-cause mortality	Healthy: L+E Maxillary Anesthesia
Total, all-cause mortality	Healthy: L+E Mandibular Anesthesia
Total, other adverse events	Diabetics: L+C Maxillary Anesthesia	0	29
Total, other adverse events	Diabetics: L+C Mandibular Anesthesia	0	30

1 to 10 of 24Source ClinicalTrials.gov

See all 24 adverse event totals

Papers0

The papers the trial lists on ClinicalTrials.gov.

None in this release.

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons0

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

None in this release.

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT02371759

GET https://conductscience.org/api/trials/v1/NCT02371759/registered?page=2

API reference For AI assistants