Trial · NCT02374593
Targeted Levothyroxine Dosing in Infants With Congenital Hypothyroidism
NCT02374593, Not applicable, Completed, Erica Eugster; results first posted 2017-10-09
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Targeted Levothyroxine Dosing in Infants With Congenital Hypothyroidism. Trials, record NCT02374593. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT02374593
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Targeted Levothyroxine Dosing in Infants With Congenital Hypothyroidism
- NCT number
- NCT02374593
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 24 participants, actual
- Lead sponsor
- Erica Eugster
- Conditions
- Congenital Hypothyroidism
- Interventions
- Levothyroxine, Ultrasound
- First posted
- 2015-03-02
- Last updated
- 2017-10-09
- Results first posted
- 2017-10-09
Source ClinicalTrials.gov
Registered outcomes2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Dose Adjustments | 6 months | Thyroid labs (TSH and fT4/T4) will be monitored per standard care: 2 weeks after initiation of levothyroxine and once monthly during the first 6 months of treatment. The number of dose adjustments required per participant during the first 6 months of treatment were recorded. |
| Secondary | Number of Adjustments Due to Overtreatment in Subjects With Athyreosis, Ectopic and Eutopic Thyroid Glands Compared With Controls | 6 months | Whether the dose adjustment was made for overtreatment was noted as based on TSH and fT4/T4 results |
Source ClinicalTrials.gov
Outcomes2
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as |
|---|---|---|---|---|---|
| PRIMARY | Dose Adjustments | 6 months | Number of dose adjustments | MEAN | |
| SECONDARY | Number of Adjustments Due to Overtreatment in Subjects With Athyreosis, Ectopic and Eutopic Thyroid Glands Compared With Controls | 6 months | dose adjustments | MEAN |
Source ClinicalTrials.gov
Results by group6
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units |
|---|---|---|---|---|---|
| Dose Adjustments | Targeted Dosing | 2.5 | Standard Error 0.334 | Number of dose adjustments | |
| Dose Adjustments | Historical Control | 2.4 | Standard Error 0.211 | Number of dose adjustments | |
| Number of Adjustments Due to Overtreatment in Subjects With Athyreosis, Ectopic and Eutopic Thyroid Glands Compared With Controls | Patients With Athyreosis | 2.7 | Standard Error 0.275 | dose adjustments | |
| Number of Adjustments Due to Overtreatment in Subjects With Athyreosis, Ectopic and Eutopic Thyroid Glands Compared With Controls | Patients With Dysgenetic Thyroids | 2 | Standard Error 0.275 | dose adjustments | |
| Number of Adjustments Due to Overtreatment in Subjects With Athyreosis, Ectopic and Eutopic Thyroid Glands Compared With Controls | Patients With Eutopic Thyroids | 1 | Standard Error 0.275 | dose adjustments | |
| Number of Adjustments Due to Overtreatment in Subjects With Athyreosis, Ectopic and Eutopic Thyroid Glands Compared With Controls | Historical Controls | 2 | Standard Error 0.275 | dose adjustments |
Source ClinicalTrials.gov
Participant flow6
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted |
|---|---|---|---|---|
| Overall Study | STARTED | Targeted Dosing | 24 | |
| Overall Study | STARTED | Historical Control | 44 | |
| Overall Study | COMPLETED | Targeted Dosing | 22 | |
| Overall Study | COMPLETED | Historical Control | 44 | |
| Overall Study | NOT COMPLETED | Targeted Dosing | 2 | |
| Overall Study | NOT COMPLETED | Historical Control | 0 |
Source ClinicalTrials.gov
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals6
The totals the trial posted for each group.
| Total | Group | Affected | At risk |
|---|---|---|---|
| Total, all-cause mortality | Targeted Dosing | ||
| Total, all-cause mortality | Historical Control | ||
| Total, other adverse events | Targeted Dosing | 0 | 0 |
| Total, other adverse events | Historical Control | 0 | 0 |
| Total, serious adverse events | Targeted Dosing | 0 | 0 |
| Total, serious adverse events | Historical Control | 0 | 0 |
Source ClinicalTrials.gov
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT02374593
GET https://conductscience.org/api/trials/v1/NCT02374593/registered